MALL

MALL
Identifiers
Aliases	MALL, BENE, mal, T-cell differentiation protein like, mal, T cell differentiation protein like
External IDs	OMIM: 602022; MGI: 2385152; HomoloGene: 3965; GeneCards: MALL; OMA:MALL - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	110,116,022 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	127,571,852 bp
RNA expression pattern
	Top expressed in
	duodenum; ; mucosa of transverse colon; ; epithelium of bronchus; ; rectum; ; vagina; ; skin of leg; ; upper lobe of left lung; ; skin of abdomen; ; islet of Langerhans; ; tonsil;
	Top expressed in
	esophagus; ; intestinal villus; ; duodenum; ; ileum; ; jejunum; ; lip; ; conjunctival fornix; ; large intestine; ; colon; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; structural constituent of myelin sheath;
Cellular component	Golgi membrane; clathrin-coated vesicle; plasma membrane; membrane; membrane raft; integral component of membrane; cytoplasmic vesicle;
Biological process	cholesterol homeostasis; membrane raft polarization; protein localization; myelination;
	Sources:Amigo / QuickGO
Orthologs
	7851
	228576
	ENSG00000144063
	ENSMUSG00000027377
	Q13021
	Q91X49
	NM_005434; NM_001371559; NM_001371560
	NM_145532
	NP_005425; NP_001358488; NP_001358489
	NP_663507
	Wikidata
View/Edit Human	View/Edit Mouse

MAL-like protein is a protein that in humans is encoded by the MALL gene.^[5]^[6]

This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid-enriched membrane (GEM) and cholesterol-enriched membrane rafts. It interacts with caveolin-1.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144063 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027377 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hildebrandt F, Otto E, Rensing C, Nothwang HG, Vollmer M, Adolphs J, Hanusch H, Brandis M (Nov 1997). "A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1". Nat Genet. 17 (2): 149–53. doi:10.1038/ng1097-149. PMID 9326933. S2CID 38035697.
^ ^a ^b "Entrez Gene: MALL mal, T-cell differentiation protein-like".

Kurdina MI, Denisov LE (1993). "[An evaluation of the efficacy of dispensary care as a method for the active detection of skin melanoma]". Klinicheskaia Meditsina. 70 (11–12): 68–70. PMID 1294831.
Lautner-Rieske A, Thiebe R, Zachau HG (1995). "Searching for non-V kappa transcripts from the human immunoglobulin kappa locus". Gene. 159 (2): 199–202. doi:10.1016/0378-1119(95)00161-X. PMID 7622049.
Magyar JP, Ebensperger C, Schaeren-Wiemers N, Suter U (1997). "Myelin and lymphocyte protein (MAL/MVP17/VIP17) and plasmolipin are members of an extended gene family". Gene. 189 (2): 269–75. doi:10.1016/S0378-1119(96)00861-X. PMID 9168137.
Saunier S, Calado J, Heilig R, et al. (1998). "A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis". Hum. Mol. Genet. 6 (13): 2317–23. doi:10.1093/hmg/6.13.2317. PMID 9361039.
de Marco MC, Kremer L, Albar JP, et al. (2001). "BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells". J. Biol. Chem. 276 (25): 23009–17. doi:10.1074/jbc.M009739200. PMID 11294831.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000144063 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027377 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9326933-5] Hildebrandt F, Otto E, Rensing C, Nothwang HG, Vollmer M, Adolphs J, Hanusch H, Brandis M (Nov 1997). "A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1". Nat Genet. 17 (2): 149–53. doi:10.1038/ng1097-149. PMID 9326933. S2CID 38035697.

[entrez-6] "Entrez Gene: MALL mal, T-cell differentiation protein-like".

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References

Further reading