Lynne M. Angerer
Lynne Marie Musgrave Angerer | |
|---|---|
| Born | December 7, 1944 |
| Died | March 3, 2013 |
| Alma mater | Ohio State University (B. S., 1966) (M.S., 1967) Johns Hopkins University (Ph. D., 1973) |
| Known for | sea urchin in situ hybridization |
| Spouse | Robert C. Angerer |
| Children | Jennifer Lynne Angerer & Mark Alan Angerer |
| Scientific career | |
| Fields | Developmental Biologist |
| Institutions | University of Rochester |
| Thesis | Physical and chemical studies on the structure of whole and selectively deproteinized deoxyribonucleoproteins from calf thymus (1973) |
Lynne Marie Musgrave Angerer (December 7, 1944 – March 30, 2013)[1] was a developmental biologist most notable for research with sea urchin development during her time spent as Head of the Developmental Mechanisms (NIDCR) at the National Institutes of Health (NIH).[2] She worked at the University of Rochester and received her PhD at Johns Hopkins University studying chromatin structures.[2]
Sea urchin research
[edit]Lynne Angerer is best known for her research of determining the cellular fates of cells in sea urchins. With her sea urchin work she was able to develop a method of in situ hybridization through the use of RNA probes.[2] Another breakthrough developed by Angerer was the use of morpholino-substituted antisense oligonucleotides in the sea urchin to knock down and interfere with individual genes.[2] This is achieved through the usual configuration of expression a ribosome attached with a phosphodiester bond being replaced by morpholine ring attached with a phosphodiamidate linkage; this process prevents the ribosome from attaching and this specific gene is not expressed.[3] Both of these procedures she developed are now the industry standard.
Angerer also discovered that specific neurons derive from a unique tissue in an organism's gut, this finding challenged the central dogma which previously stated that neurons only derived from embryonic tissues.[4] Angerer and her husband Robert played a major role in the sequencing the sea urchin genome for the first time. The sequences that she found are used widely in sea urchin studies.[2]
References
[edit]- ^ "Lynne M. Angerer Obituary" (2013), Rochester Democrat And Chronicle. Legacy.com. Retrieved 2022-02-27.
- ^ a b c d e Yaguchi, Shunsuke; Burke, Robert D. (June 2013). "Lynne M. Angerer: An originator of RNA in situ hybridization". Molecular Reproduction and Development. 80 (6): Fm i–Fm i. doi:10.1002/mrd.22198. ISSN 1040-452X. S2CID 83273629.
- ^ Doris, Kist (2003). "Adi Sethi, Graduate Student, Angerer lab" (PDF). The Nonsense Suppressor. pp. 4, 16–17. Retrieved 2022-02-27.
- ^ "Obituaries 2013". NIH Intramural Research Program. 2014-01-08. Retrieved 2022-03-31.