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Lone Gram

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Lone Gram
Born10 August 1960 (1960-08-10) (age 64)[1]
Alma materRoyal Veterinary and Agricultural University
Scientific career
ThesisIdentification, characterization, and inhibition of bacteria isolated from tropical fish (1989)

Lone Gram is Danish microbiologist known for her work in bacterial physiology, microbial communication, and biochemicals that originate from bacterial cultures. She is an elected member of the Royal Danish Academy of Sciences and Letters and has received the Order of the Dannebrog.

Education and career

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Gram's first microbiology course led her away from her initial career interests in medicine,[2] and into marine bacteria.[3] Gram has both an M.Sc. (1985)[4] and a Ph.D. (1989) from the Royal Veterinary and Agricultural University in Denmark.[5] Following her Ph.D., Gram joined the Technological Laboratory of the Danish Ministry of Fishes. In 2010 she was promoted to professor at the Technical University of Denmark. Gram has also spent time working at Harvard Medical School and at the University of New South Wales.[1]

Research

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Gram's research centers on the physiology of bacteria in the environment and using bacteria for biotechnology. Her early research examined variability in the bacteria found in spoiled fish,[6][7][8] removing bacterial biofilms,[9] and preventing biofilms using compounds from the red algae Delisea pulchra.[10] She has examined the interactions across different species of bacteria,[11] and the production of compounds that send messages among bacteria.[12] Her research includes investigations bacterial attachment to surfaces,[13] and quantification of hydrogen sulfide production by bacteria associated with fish.[14] From 2006 until 2007, Gram participated in the Galathea 3 expeditions,[1][15] and she is using the bacterial cultures initiated during the project to mine bacteria for chemical compounds that may be useful to people.[16] Gram's research extends to investigations of the global distribution of bacterial species,[17] and an examination of how the presence of varying nutrients alters the chemical compounds produced by bacteria.[18]

Selected publications

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  • Gram, Lone; Huss, Hans Henrik (1996-11-01). "Microbiological spoilage of fish and fish products". International Journal of Food Microbiology. Specific Spoilage Organisms. 33 (1): 121–137. doi:10.1016/0168-1605(96)01134-8. ISSN 0168-1605. PMID 8913813.
  • Gram, Lone; Melchiorsen, Jette; Spanggaard, Bettina; Huber, Ingrid; Nielsen, Torben F. (1999-03-01). "Inhibition of Vibrio anguillarum byPseudomonas fluorescens AH2, a Possible Probiotic Treatment of Fish". Applied and Environmental Microbiology. 65 (3): 969–973. Bibcode:1999ApEnM..65..969G. doi:10.1128/AEM.65.3.969-973.1999. PMC 91130. PMID 10049849.
  • Huber, I.; Spanggaard, B.; Appel, K.F.; Rossen, L.; Nielsen, T.; Gram, L. (2004). "Phylogenetic analysis and in situ identification of the intestinal microbial community of rainbow trout (Oncorhynchus mykiss, Walbaum)". Journal of Applied Microbiology. 96 (1): 117–132. doi:10.1046/j.1365-2672.2003.02109.x. ISSN 1364-5072. PMID 14678165. S2CID 23137898.
  • Gram, Lone; Grossart, Hans-Peter; Schlingloff, Andrea; Kiørboe, Thomas (2002). "Possible Quorum Sensing in Marine Snow Bacteria: Production of Acylated Homoserine Lactones by Roseobacter Strains Isolated from Marine Snow". Applied and Environmental Microbiology. 68 (8): 4111–4116. Bibcode:2002ApEnM..68.4111G. doi:10.1128/aem.68.8.4111-4116.2002. ISSN 4111-4116. PMC 123997. PMID 12147515.

Awards and honors

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In 2008, Gram received Tagea Brandt Rejselegat, an award given to Danish women to recognize significant contributions in science, literature, or art.[19] In 2016, Gram received the Villum Kann Rasmussen Annual Award in Science and Technology, which is given in recognition of "a particularly valuable contribution to the technical and natural sciences".[1] In 2018, she received the Order of the Dannebrog.[20] In 2020, Gram was elected a member of the Royal Danish Academy of Sciences and Letters.[19][2]

Personal life

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Gram's great-grandfather[21] was Hans Christian Gram who developed the Gram stain, a commonly used technique in microbial ecology.[22] Gram is also distantly related to the Danish historian Hans Gram.[2]

References

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  1. ^ a b c d "Bacteria researcher receives annual award of DKK 5 million - DTU". www.dtu.dk. Retrieved 2022-01-15.
  2. ^ a b c "Lone Gram Royal Academy". www.royalacademy.dk. March 31, 2021. Retrieved 2022-01-15.
  3. ^ "Professor Lone Gram". www.royalacademy.dk. Retrieved 2022-01-15.
  4. ^ Gram, Lone (1985). Konduktansmaling og mikrokalorimetri som hurtigmetoder i levnedsmiddelhygiejne: en undersgelse af fersk fisk (Thesis) (in Danish). Kobenhavn: Institut for Veterinr Mikrobiologi og Hygiejne, KVL. OCLC 476091721.
  5. ^ Gram, Lone (1989). Identification, characterization, and inhibition of bacteria isolated from tropical fish (Thesis). Copenhagen, Denmark. OCLC 222426373.
  6. ^ Gram, Lone; Trolle, Gunilla; Huss, Hans Henrik (1987-01-01). "Detection of specific spoilage bacteria from fish stored at low (0°C) and high (20°C) temperatures". International Journal of Food Microbiology. 4 (1): 65–72. doi:10.1016/0168-1605(87)90060-2. ISSN 0168-1605.
  7. ^ Gram, L. (1993). "Inhibitory effect against pathogenic and spoilage bacteria of Pseudomonas strains isolated from spoiled and fresh fish". Applied and Environmental Microbiology. 59 (7): 2197–2203. Bibcode:1993ApEnM..59.2197G. doi:10.1128/aem.59.7.2197-2203.1993. PMC 182257. PMID 8357253.
  8. ^ Gram, Lone; Huss, Hans Henrik (1996-11-01). "Microbiological spoilage of fish and fish products". International Journal of Food Microbiology. Specific Spoilage Organisms. 33 (1): 121–137. doi:10.1016/0168-1605(96)01134-8. ISSN 0168-1605. PMID 8913813.
  9. ^ Johansen, C.; Falholt, P.; Gram, L. (1997). "Enzymatic removal and disinfection of bacterial biofilms". Applied and Environmental Microbiology. 63 (9): 3724–3728. Bibcode:1997ApEnM..63.3724J. doi:10.1128/aem.63.9.3724-3728.1997. PMC 168680. PMID 9293025.
  10. ^ Maximilien, R; de Nys, R; Holmström, C; Gram, L; Givskov, M; Crass, K; Kjelleberg, S; Steinberg, Pd (1998). "Chemical mediation of bacterial surface colonisation by secondary metabolites from the red alga Delisea pulchra". Aquatic Microbial Ecology. 15: 233–246. doi:10.3354/ame015233. ISSN 0948-3055.
  11. ^ Gram, Lone; Melchiorsen, Jette; Spanggaard, Bettina; Huber, Ingrid; Nielsen, Torben F. (1999-03-01). "Inhibition of Vibrio anguillarum byPseudomonas fluorescens AH2, a Possible Probiotic Treatment of Fish". Applied and Environmental Microbiology. 65 (3): 969–973. Bibcode:1999ApEnM..65..969G. doi:10.1128/AEM.65.3.969-973.1999. PMC 91130. PMID 10049849.
  12. ^ Gram, Lone; Christensen, Allan Beck; Ravn, Lars; Molin, Søren; Givskov, Michael (1999-08-01). "Production of Acylated Homoserine Lactones by Psychrotrophic Members of the Enterobacteriaceae Isolated from Foods". Applied and Environmental Microbiology. 65 (8): 3458–3463. Bibcode:1999ApEnM..65.3458G. doi:10.1128/AEM.65.8.3458-3463.1999. PMC 91519. PMID 10427034. S2CID 30130863.
  13. ^ Kingshott, Peter; Wei, Jiang; Bagge-Ravn, Dorthe; Gadegaard, Nikolaj; Gram, Lone (2003-08-01). "Covalent Attachment of Poly(ethylene glycol) to Surfaces, Critical for Reducing Bacterial Adhesion". Langmuir. 19 (17): 6912–6921. doi:10.1021/la034032m. ISSN 0743-7463.
  14. ^ Vogel, Birte Fonnesbech; Venkateswaran, Kasthuri; Satomi, Masataka; Gram, Lone (2005). "Identification of Shewanella baltica as the Most Important H2S-Producing Species during Iced Storage of Danish Marine Fish". Applied and Environmental Microbiology. 71 (11): 6689–6697. Bibcode:2005ApEnM..71.6689V. doi:10.1128/AEM.71.11.6689-6697.2005. PMC 1287644. PMID 16269698.
  15. ^ Tachibana, Chris (2013-05-16). "Blue biotechnology wave - Nordic Life Science". Nordic Life Science – the leading Nordic life science news service. Retrieved 2022-01-15.
  16. ^ Gram, Lone; Melchiorsen, Jette; Bruhn, Jesper Bartholin (2010). "Antibacterial Activity of Marine Culturable Bacteria Collected from a Global Sampling of Ocean Surface Waters and Surface Swabs of Marine Organisms". Marine Biotechnology. 12 (4): 439–451. doi:10.1007/s10126-009-9233-y. ISSN 1436-2228. PMID 19823914. S2CID 27071269.
  17. ^ Sonnenschein, Eva C; Nielsen, Kristian F; D'Alvise, Paul; Porsby, Cisse H; Melchiorsen, Jette; Heilmann, Jens; Kalatzis, Panos G; López-Pérez, Mario; Bunk, Boyke; Spröer, Cathrin; Middelboe, Mathias (2017). "Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis". The ISME Journal. 11 (2): 569–583. doi:10.1038/ismej.2016.111. ISSN 1751-7362. PMC 5270555. PMID 27552638.
  18. ^ Giubergia, Sonia; Phippen, Christopher; Gotfredsen, Charlotte H.; Nielsen, Kristian Fog; Gram, Lone (2016-04-29). "Influence of Niche-Specific Nutrients on Secondary Metabolism in Vibrionaceae". Applied and Environmental Microbiology. 82 (13): 4035–4044. Bibcode:2016ApEnM..82.4035G. doi:10.1128/AEM.00730-16. PMC 4907173. PMID 27129958.
  19. ^ a b "Lone Gram". Welcome to DTU Research Database. Retrieved 2022-01-15.
  20. ^ "Professor Lone Gran decorated with the Order of Dannebrog - CeMiSt". Center for Microbial Secondary Metabolites. Retrieved 2022-01-15.
  21. ^ Shekhar, Akarsh (2020-10-22). "Hans Christian Gram: 8 Facts About The Man Who Invented the Famous 'Stain Technique'". DailyHawker. Retrieved 2022-01-15.
  22. ^ "Opening of the Danish National Research Foundation DNRF, Center of Excellence:Center for microbial secondary metabolites (Cemist)" (PDF). Danish National Research Foundation. February 27, 2017.
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