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List of cardiovascular clinical trials

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This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources.

This is a list of cardiovascular clinical trials, categorized and alphabetized.

Acute coronary syndrome

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Arrhythmias

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  • Cardiac Arrhythmia Suppression Trial (CAST) - randomized controlled trial designed to test the hypothesis that suppression of premature ventricular complexes (PVC) with class I antiarrhythmic agents after a myocardial infarction (MI) would reduce mortality.[2][3]

Atrial fibrillation

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Coronary artery disease

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Epidemiology

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  • Busselton Health Study - a prospective cohort study of residents of the Western Australian city of Busselton regarding cardiovascular disease, pulmonary function, diabetes, and cancer.[4]
  • Caerphilly Heart Disease Study - prospective cohort study of the residents from Caerphilly, South Wales, to examine relationships between a wide range of social, lifestyle, dietary, and other factors with incident vascular disease.[5]
  • Framingham Heart Study - long-term, ongoing cardiovascular cohort study of residents of the city of Framingham, Massachusetts.[6]
  • Nurses' Health Study - series of prospective studies that examine epidemiology and the long-term effects of nutrition, hormones, environment, and nurses' work-life on health and disease development.[7]
  • Seven Countries Study - a prospective cohort study that examined the relationships between lifestyle, diet, coronary heart disease, and stroke in different populations.[8]
  • Strong Heart Study - cohort study of cardiovascular disease (CVD) and its risk factors among American Indian men and women.[9]

Heart failure

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  • Multicenter Automatic Defibrillator Implantation Trial (MADIT) - a series of randomized controlled trials designed to test the hypothesis that implantable cardioverter defibrillator (ICD) therapy in moderately high-risk coronary patients would significantly reduce death.[10]
  • RALES (trial) - randomized controlled trial comparing spironolactone to placebo when added to standard care in patients with advanced heart failure.[11]

Hypertension

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Lipids

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  • AIM-HIGH (trial) - a randomized controlled trial of niacin for increasing HDL levels.[14]
  • HDL-Atherosclerosis Treatment Study (HATS) - a randomized controlled trial that studied people with coronary heart disease and compared a combination of simvastatin and niacin with antioxidant vitamin therapy.[15]
  • Heart Protection Study - a randomized controlled trial that studied the cholesterol-lowering drug simvastatin and vitamin supplementation in people at risk of cardiovascular disease.[16]
  • JUPITER trial - a randomized controlled trial to evaluate whether statins reduce heart attacks and strokes in people with normal cholesterol levels.[17]
  • PROVE-IT TIMI 22 - a randomized controlled trial that compared intensive vs. moderate-dose statin therapy immediately after a heart attack.[18]
  • Scandinavian Simvastatin Survival Study (4S) - a randomized controlled trial that studied the use of the cholesterol-lowering drug simvastatin in people with moderately raised cholesterol and coronary heart disease.[19]
  • West of Scotland Coronary Prevention Study (WOSCOPS) - a randomized controlled trial that compared the cholesterol-lowering drug pravastatin in patients with no previous history of a heart attack.[20]

Valvular diseases

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References

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  1. ^ Hennekens, Charles H. (February 1998). "Trials of Thrombolytic Therapy : The International Studies of Infarct Survival Experience". Journal of Interventional Cardiology. 11 (1): 1–7. doi:10.1111/j.1540-8183.1998.tb00089.x.
  2. ^ Cardiac Arrhythmia Suppression Trial (CAST) Investigators (10 August 1989). "Preliminary Report: Effect of Encainide and Flecainide on Mortality in a Randomized Trial of Arrhythmia Suppression after Myocardial Infarction". New England Journal of Medicine. 321 (6): 406–412. doi:10.1056/NEJM198908103210629. PMID 2473403.
  3. ^ Echt, Debra S.; Liebson, Philip R.; Mitchell, L. Brent; et al. (21 March 1991). "Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo: The Cardiac Arrhythmia Suppression Trial". New England Journal of Medicine. 324 (12): 781–788. doi:10.1056/NEJM199103213241201. PMID 1900101.
  4. ^ Cullen, K. J. (September 1972). "Mass Health Examinations in the Busselton Population, 1966 to 1970". Medical Journal of Australia. 2 (13): 714–718. doi:10.5694/j.1326-5377.1972.tb103506.x. PMID 5084969.
  5. ^ "Caerphilly and Speedwell collaborative heart disease studies. The Caerphilly and Speedwell Collaborative Group". Journal of Epidemiology & Community Health. 38 (3): 259–262. 1 September 1984. doi:10.1136/jech.38.3.259. PMC 1052363. PMID 6332166.
  6. ^ Mahmood, Syed S; Levy, Daniel; Vasan, Ramachandran S; et al. (March 2014). "The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective". The Lancet. 383 (9921): 999–1008. doi:10.1016/S0140-6736(13)61752-3. PMC 4159698. PMID 24084292.
  7. ^ Belanger, CF; Hennekens, CH; Rosner, B; et al. (June 1978). "The nurses' health study". The American Journal of Nursing. 78 (6): 1039–40. PMID 248266.
  8. ^ Keys, Ancel; Taylor, Henry Longstreet; Blackburn, Henry; et al. (September 1963). "Coronary Heart Disease among Minnesota Business and Professional Men Followed Fifteen Years". Circulation. 28 (3): 381–395. doi:10.1161/01.CIR.28.3.381. PMID 14059458.
  9. ^ Howard, Barbara V.; Lee, Elisa T.; Cowan, Linda D.; et al. (11 May 1999). "Rising Tide of Cardiovascular Disease in American Indians: The Strong Heart Study". Circulation. 99 (18): 2389–2395. doi:10.1161/01.cir.99.18.2389. PMID 10318659.
  10. ^ Moss, Arthur J.; Hall, W. Jackson; Cannom, David S.; et al. (26 December 1996). "Improved Survival with an Implanted Defibrillator in Patients with Coronary Disease at High Risk for Ventricular Arrhythmia". New England Journal of Medicine. 335 (26): 1933–1940. doi:10.1056/NEJM199612263352601. PMID 8960472.
  11. ^ Pitt, Bertram; Zannad, Faiez; Remme, Willem J.; et al. (2 September 1999). "The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure". New England Journal of Medicine. 341 (10): 709–717. doi:10.1056/NEJM199909023411001. PMID 10471456.
  12. ^ The Allhat Officers And Coordinators For The Allhat Collaborative Research Group (18 December 2002). "Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)". JAMA: The Journal of the American Medical Association. 288 (23): 2981–2997. doi:10.1001/jama.288.23.2981. PMID 12479763.
  13. ^ SPRINT Research Group; Wright Jr, J. T.; Williamson, J. D.; Whelton, P. K.; Snyder, J. K.; Sink, K. M.; Rocco, M. V.; Reboussin, D. M.; Rahman, M.; Oparil, S.; Lewis, C. E.; Kimmel, P. L.; Johnson, K. C.; Goff Jr, D. C.; Fine, L. J.; Cutler, J. A.; Cushman, W. C.; Cheung, A. K.; Ambrosius, W. T. (26 November 2015). "A Randomized Trial of Intensive versus Standard Blood-Pressure Control". New England Journal of Medicine. 373 (22): 2103–2116. doi:10.1056/NEJMoa1511939. PMC 4689591. PMID 26551272.
  14. ^ Boden, William E; Probstfield, Jeffrey L; Anderson, Todd; et al. (15 December 2011). "Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy". New England Journal of Medicine. 365 (24): 2255–2267. doi:10.1056/nejmoa1107579. PMID 22085343.
  15. ^ Kastelein, John J.P.; Akdim, Fatima; Stroes, Erik S.G.; et al. (3 April 2008). "Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia". New England Journal of Medicine. 358 (14): 1431–1443. doi:10.1056/NEJMoa0800742. PMID 18376000.
  16. ^ Heart Protection Study Collaborative Group (July 2002). "MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebo controlled trial". The Lancet. 360 (9326): 7–22. doi:10.1016/S0140-6736(02)09327-3. PMID 12114036.
  17. ^ Ridker, Paul M; Danielson, Eleanor; Fonseca, Francisco A.H.; et al. (20 November 2008). "Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein". New England Journal of Medicine. 359 (21): 2195–2207. doi:10.1056/NEJMoa0807646. PMID 18997196.
  18. ^ Cannon, Christopher P.; Braunwald, Eugene; McCabe, Carolyn H.; et al. (8 April 2004). "Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes". New England Journal of Medicine. 350 (15): 1495–1504. doi:10.1056/NEJMoa040583. PMID 15007110.
  19. ^ "Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)". Lancet. 344 (8934): 1383–9. 19 November 1994. PMID 7968073.
  20. ^ Shepherd, James; Cobbe, Stuart M.; Ford, Ian; et al. (16 November 1995). "Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia". New England Journal of Medicine. 333 (20): 1301–1308. doi:10.1056/NEJM199511163332001. PMID 7566020.
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