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List of adverse effects of valproate

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List of adverse effects of valproate by frequency:[1][2][3][4]

Very common (>10%)

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  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Low platelet count (dose-related)
  • Tremor (dose-related)
  • Hair loss (usually temporary)
  • Drowsiness
  • Dizziness
  • Hyperandrogenism in females
  • Seeing double
  • Indigestion
  • Lazy eye
  • Infection
  • Tinnitus
  • Elevated aminotransferase concentrations (dose-related; indicative of liver injury)

Common (1-10%)

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  • High blood levels of ammonia without symptoms

Uncommon (0.1-1%)

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Rare (<0.1% frequency)

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  • Liver failure
  • Pancreatitis (these two usually occur in first 6 months and can be fatal)
  • Leukopenia (low white blood cell count)
  • Neutropenia (low neutrophil count)
  • Pure red cell aplasia
  • Agranulocytosis
  • Extrapyramidal syndrome (including parkinsonism, may be reversible)
  • Brain problems due to high ammonia levels
  • Low body temperature
  • Hypersensitivity reactions including multi-organ hypersensitivity syndrome
  • Eosinophilic pleural effusion
  • Bone fractures (reduced BMD with long-term use)

References

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  1. ^ "Depakene, Stavzor (valproic acid) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 13 February 2014.
  2. ^ Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3.
  3. ^ Joint Formulary Committee. British National Formulary (BNF) (65 ed.). London, UK: Pharmaceutical Press. ISBN 978-0-85711-084-8.
  4. ^ "Valpro sodium valproate" (PDF). TGA eBusiness Services. Alphapharm Pty Limited. 16 December 2013. Retrieved 14 February 2014.
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