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Lianne Sheppard

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Elizabeth Anne (Lianne) Sheppard is an American statistician. She specializes in biostatistics and environmental statistics, and in particular in the effects of air quality on health. She is a Professor of Environmental and Occupational Health Sciences and a Professor of Biostatistics in the University of Washington School of Public Health. In 2021, Dr. Sheppard was named to the Rohm & Haas Endowed Professorship of Public Health Sciences.[1][2]

Education

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Dr. Sheppard graduated from Johns Hopkins University with a bachelor's degree in psychology in 1979, and returned to Johns Hopkins for a master's degree in biostatistics in 1985. She completed her Ph.D. in biostatistics in 1992 at the University of Washington.[1] Her dissertation, Aggregate Data Methods for Relative Risk Parameter Estimation in Diet and Disease Prevention Research, was supervised by Ross L. Prentice.[3]

Research contributions

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Dr. Sheppard's methodological research interests are observational study methods, exposure modeling, study design, and epidemiology. Her applied research focuses on the health effects of occupational and environmental exposures. She is principal investigator of the NIH-funded training grant Biostatistics, Epidemiologic & Bioinformatics Training in Environmental Health, and she oversees the SURE-EH training program, a project to promote diversity in the environmental health sciences. She is also co-principal investigator of the NIH-funded Adult Changes in Thought Air Pollution study and of a Health Effects Institute study to better understand the role of exposure assessment design and modeling in inference about air pollution health effects.[2]

She has published over 190 peer-reviewed publications.[4] Among her principal methodological/statistical contributions to the environmental health field are 1) developing statistical methods for aggregate data studies;[5][6][7] 2) developing measurement error correction methods for inference about health effects for applications to air pollution cohort studies;[8][9] 3) advancements in spatial and spatio-temporal modeling methods for air pollution exposures;[10][11] and 4) referent selection and analysis approaches for case-crossover study design for air pollution epidemiology.[12][13] She has also helped advance scientific understanding of the adverse effects of a variety of environmental exposures, including air pollution,[14][15][16][17] noise,[18] manganese,[19][20] and pesticides.[21][22]

Policy Contributions

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In 2016, Dr. Sheppard was chosen to chair a panel of the United States Environmental Protection Agency to examine in what quantities nitrogen oxides are harmful.[23] However, in 2018 the Trump administration replaced Dr. Sheppard and other academic experts on the panel with public health officials, at the same time disbanding a related panel on particulate pollution. Dr. Sheppard was quoted as saying that these changes would "result in poorer-quality scientific oversight".[24] Dr. Sheppard is also a participant in a lawsuit against new agency rules preventing scientists funded by the agency from serving on its panels, a move that caused her to step away from a three-million-dollar grant.[25]

In 2021, Dr. Sheppard was appointed chair of the United States Environmental Protection Agency Clean Air Scientific Advisory Committee (CASAC).[26]

Recognition

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Dr. Sheppard was chosen as a Fellow of the American Statistical Association in 2006, "for contributions to observational studies and environmental occupational epidemiology; for thoughtful commentary in science-policy areas; and for commitment to bringing statistical methodology to elementary and high school education.[27]

In 2020, she received the International Society for Environmental Epidemiology (ISEE) Research Integrity Award.[28]

References

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  1. ^ a b "Lianne Sheppard", Faculty, University of Washington School of Public Health, retrieved 2018-10-29
  2. ^ a b Lianne Sheppard, University of Washington School of Public Health Department of Environmental and Occupational Health Sciences
  3. ^ Lianne Sheppard at the Mathematics Genealogy Project
  4. ^ Google Scholar Page for Lianne Sheppard
  5. ^ Aggregate data studies of disease risk factors
  6. ^ Sheppard, L.; Prentice, R. L. (1995), "On the reliability and precision of within- and between- population estimates of relative rate parameters", Biometrics, 51 (3): 853–863, doi:10.2307/2532987, JSTOR 2532987, PMID 7548704
  7. ^ Sheppard, L.; Prentice, R. L.; Rossing, M. A. (1996), "Design considerations for estimation of exposure effects on disease risk, using aggregate data studies", Statistics in Medicine, 15 (17–18): 1849–1858, doi:10.1002/(SICI)1097-0258(19960915)15:17<1849::AID-SIM396>3.0.CO;2-4, PMID 8888477
  8. ^ Szpiro, A. A.; Sheppard, L.; Lumley, T. (2011), "Efficient measurement error correction with spatially misaligned data", Biostatistics, 12 (4): 610–623, doi:10.1093/biostatistics/kxq083, PMC 3169665, PMID 21252080
  9. ^ Szpiro, A. A.; Paciorek, C. J.; Sheppard, L. (2011), "Does more accurate exposure prediction necessarily improve health effect estimates?", Epidemiology, 22 (5): 680–685, doi:10.1097/EDE.0b013e3182254cc6, PMC 3195520, PMID 21716114
  10. ^ Seixas, N. S.; Sheppard, L. (1996), "Maximizing accuracy and precision using individual and grouped exposure assessments", Scandinavian Journal of Work, Environment & Health, 22 (2): 94–101, doi:10.5271/sjweh.116, PMID 8738886
  11. ^ Lindström, J.; Szpiro, A. A.; Sampson, P. D.; Oron, A. P.; Richards, M.; Larson, T. V.; Sheppard, L. (2014), "A Flexible Spatio-Temporal Model for Air Pollution with Spatial and Spatio-Temporal Covariates", Environmental and Ecological Statistics, 21 (3): 411–433, doi:10.1007/s10651-013-0261-4, PMC 4174563, PMID 25264424
  12. ^ Levy, D.; Lumley, T.; Sheppard, L.; Kaufman, J.; Checkoway, H. (2001), "Referent selection in case-crossover analyses of acute health effects of air pollution", Epidemiology, 12 (2): 186–192, doi:10.1097/00001648-200103000-00010, PMID 11246579, S2CID 36828973
  13. ^ Janes, H.; Sheppard, L.; Lumley, T. (2005), "Case-crossover analyses of air pollution exposure data: referent selection strategies and their implications for bias", Epidemiology, 16 (6): 717–726, doi:10.1097/01.ede.0000181315.18836.9d, PMID 16222160, S2CID 24915212
  14. ^ Wang, Meng; Aaron, Carrie Pistenmaa; Madrigano, Jaime; Hoffman, Eric A.; Angelini, Elsa; Yang, Jie; Laine, Andrew; Vetterli, Thomas M.; Kinney, Patrick L.; Sampson, Paul D.; Sheppard, Lianne E.; Szpiro, Adam A.; Adar, Sara D.; Kirwa, Kipruto; Smith, Benjamin; Lederer, David J.; Diez-Roux, Ana V.; Vedal, Sverre; Kaufman, Joel D.; Barr, R. Graham (2019), "Association Between Long-term Exposure to Ambient Air Pollution and Change in Quantitatively Assessed Emphysema and Lung Function", JAMA, 322 (6): 546–556, doi:10.1001/jama.2019.10255, PMC 6692674, PMID 31408135
  15. ^ Kaufman, J. D.; Adar, S. D.; Barr, R. G.; Budoff, M.; Burke, G. L.; Curl, C. L.; Daviglus, M. L.; Diez Roux, A. V.; Gassett, A. J.; Jacobs Jr, D. R.; Kronmal, R.; Larson, T. V.; Navas-Acien, A.; Olives, C.; Sampson, P. D.; Sheppard, L.; Siscovick, D. S.; Stein, J. H.; Szpiro, A. A.; Watson, K. E. (2016), "Association between air pollution and coronary artery calcification within six metropolitan areas in the USA (the Multi-Ethnic Study of Atherosclerosis and Air Pollution): a longitudinal cohort study", Lancet, 388 (10045): 696–704, doi:10.1016/S0140-6736(16)00378-0, PMC 5019949, PMID 27233746
  16. ^ Miller, Kristin A.; Siscovick, David S.; Sheppard, Lianne; Shepherd, Kristen; Sullivan, Jeffrey H.; Anderson, Garnet L.; Kaufman, Joel D. (2007), "Long-Term Exposure to Air Pollution and Incidence of Cardiovascular Events in Women", New England Journal of Medicine, 356 (5): 447–458, doi:10.1056/nejmoa054409, PMID 17267905
  17. ^ Shaffer, Rachel M.; Blanco, Magali N.; Li, Ge; Adar, Sara D.; Carone, Marco; Szpiro, Adam A.; Kaufman, Joel D.; Larson, Timothy V.; Larson, Eric B.; Crane, Paul K.; Sheppard, Lianne (2021), "Fine Particulate Matter and Dementia Incidence in the Adult Changes in Thought Study", Environmental Health Perspectives, 129 (8): 087001, doi:10.1289/EHP9018, PMC 8336685, PMID 34347531
  18. ^ Seixas, N. S.; Neitzel, R.; Stover, B.; Sheppard, L.; Feeney, P.; Mills, D.; Kujawa, S. (2012), "10-Year prospective study of noise exposure and hearing damage among construction workers", Occupational and Environmental Medicine, 69 (9): 643–650, doi:10.1136/oemed-2011-100578, PMC 4570847, PMID 22693267
  19. ^ Racette, B. A.; Nelson, G.; Dlamini, W. W.; Prathibha, P.; Turner, J. R.; Ushe, M.; Checkoway, H.; Sheppard, L.; Nielsen, S. S. (2021), "Severity of parkinsonism associated with environmental manganese exposure", Environmental Health: A Global Access Science Source, 20 (1): 27, doi:10.1186/s12940-021-00712-3, PMC 7962371, PMID 33722243
  20. ^ Criswell, S. R.; Nielsen, S. S.; Warden, M. N.; Flores, H. P.; Lenox-Krug, J.; Racette, S.; Sheppard, L.; Checkoway, H.; Racette, B. A. (2019), "MRI Signal Intensity and Parkinsonism in Manganese-Exposed Workers", Journal of Occupational and Environmental Medicine, 61 (8): 641–645, doi:10.1097/JOM.0000000000001634, PMC 7098806, PMID 31348423
  21. ^ Sheppard, Lianne; McGrew, Seth; Fenske, Richard A. (2020), "Flawed analysis of an intentional human dosing study and its impact on chlorpyrifos risk assessments", Environment International, 143: 105905, doi:10.1016/j.envint.2020.105905, PMID 32629200, S2CID 220387157
  22. ^ Zhang, Luoping; Rana, Iemaan; Shaffer, Rachel M.; Taioli, Emanuela; Sheppard, Lianne (2019), "Exposure to glyphosate-based herbicides and risk for non-Hodgkin lymphoma: A meta-analysis and supporting evidence", Mutation Research/Reviews in Mutation Research, 781: 186–206, doi:10.1016/j.mrrev.2019.02.001, PMC 6706269, PMID 31342895
  23. ^ Washington Professor Chairs EPA Panel to Review Nitrogen Oxides Standards, Association of Schools & Programs of Public Health, July 7, 2016
  24. ^ Friedman, Lisa (October 11, 2018), "E.P.A. to Disband a Key Scientific Review Panel on Air Pollution", The New York Times
  25. ^ Miller, Hayley (January 24, 2018), "Scientists Sue EPA Over 'Attempt To Delegitimize Science': They argue Administrator Scott Pruitt's purge of independent advisers was unlawful and unprecedented", Huffington Post
  26. ^ EPA Announces Selections of Charter Members to the Clean Air Scientific Advisory Committee, July 2021
  27. ^ Plenary & Awards Sessions presented at the 166th Annual Meeting (PDF), American Statistical Association and Committee of Presidents of Statistical Societies, p. 13, retrieved 2018-10-29
  28. ^ ISEE Awards
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