Leucine carboxyl methyltransferase 1

LCMT1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3IEI, 3O7W, 3P71
Identifiers
Aliases	LCMT1, LCMT, PPMT1, CGI-68, leucine carboxyl methyltransferase 1
External IDs	OMIM: 610286; MGI: 1353593; HomoloGene: 41123; GeneCards: LCMT1; OMA:LCMT1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	25,178,231 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	123,029,581 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; body of pancreas; ; prefrontal cortex; ; oocyte; ; nucleus accumbens; ; right frontal lobe; ; gonad; ; pons; ; Brodmann area 23; ; anterior cingulate cortex;
	Top expressed in
	lacrimal gland; ; dentate gyrus of hippocampal formation granule cell; ; Region I of hippocampus proper; ; ventromedial nucleus; ; medial ganglionic eminence; ; anterior amygdaloid area; ; nucleus accumbens; ; nucleus of stria terminalis; ; dorsomedial hypothalamic nucleus; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; protein methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity; transferase activity; protein binding; protein C-terminal carboxyl O-methyltransferase activity; protein C-terminal leucine carboxyl O-methyltransferase activity;
Cellular component	cytosol; nucleoplasm;
Biological process	regulation of mitotic cell cycle spindle assembly checkpoint; methylation; C-terminal protein methylation; regulation of glucose metabolic process; regulation of apoptotic process; negative regulation of protein-containing complex assembly; protein methylation; G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	51451
	30949
	ENSG00000205629
	ENSMUSG00000030763
	Q9UIC8
	n/a
	NM_001032391; NM_016309; NM_016015
	NM_025304; NM_001355050
	NP_001027563; NP_057393
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine carboxyl methyltransferase 1 is an enzyme that in humans is encoded by the LCMT1 gene.^[5]^[6]

Interactions

LCMT1 has been shown to interact with FXR2.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000205629 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030763 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
^ "Entrez Gene: LCMT1 leucine carboxyl methyltransferase 1".
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Lee JA, Pallas DC (Oct 2007). "Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells". The Journal of Biological Chemistry. 282 (42): 30974–84. doi:10.1074/jbc.M704861200. PMC 3516869. PMID 17724024.
De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J (Dec 1999). "Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue". Biochemistry. 38 (50): 16539–47. doi:10.1021/bi991646a. PMID 10600115.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000205629 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030763 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10810093-5] Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

[entrez-6] "Entrez Gene: LCMT1 leucine carboxyl methyltransferase 1".

[pmid16189514-7] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Interactions

References

Further reading