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Leiomyoma

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Leiomyoma
Other namesleiomyomas, leiomyomata
Uterine lipoleiomyoma, a type of leiomyoma. H&E stain.
SpecialtyOncology Edit this on Wikidata

A leiomyoma, also known as a fibroid, is a benign smooth muscle tumor that very rarely becomes cancer (0.1%). They can occur in any organ, but the most common forms occur in the uterus, small bowel, and the esophagus. Polycythemia may occur due to increased erythropoietin production as part of a paraneoplastic syndrome.

The word is from leio- + myo- + -oma, 'smooth-muscle tumor'. The plural form can be either the English leiomyomas or the classical leiomyomata.

Uterus

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Main article: Uterine fibroids
Leiomyoma enucleated from a uterus. External surface on left; cut surface on right.
Micrograph of a small, well-circumscribed colonic leiomyoma arising from the muscularis mucosae and showing fascicles of spindle cells with eosinophilic cytoplasm and elongated, cigar-shaped nuclei
Immunohistochemistry for β-catenin in uterine leiomyoma, which is negative as there is only staining of cytoplasm but not of cell nuclei. This is a consistent finding, which helps in distinguishing such tumors from β-catenin positive spindle cell tumors.[1]

Uterine fibroids are leiomyomata of the uterine smooth muscle. As other leiomyomata, they are benign, but may lead to excessive menstrual bleeding (menorrhagia), often cause anemia and may lead to infertility.

A rare form of these tumors is uterine lipoleiomyoma—benign tumors consisting of a mixture of adipocytes and smooth muscle cells. Uterine lipoleiomyomata have been observed together with ovarian and other pathologies and some of them may develop into liposarcoma.[2][3] These tumors are monoclonal, and non-random chromosomal abnormalities have been seen in 40% of the tumors.

Gallbladder

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Mesenchymal neoplasms of the gallbladder are rare and in particular leiomyomas of the gallbladder have been rarely reported, all of them in patients with immune system disorders. However, a case was reported in absence of associated immunodeficiency at Monash Hospital in Melbourne, Australia, in a healthy 39-year-old woman with no symptoms.[4]

Skin

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Leiomyomas of the skin are generally (1) acquired, and (2) divided into several categories:[5][6]

Esophagus, stomach and small intestines

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Leiomyoma is the most common benign mesenchymal tumor of esophagus and second most common benign tumor of the small bowel (with gastrointestinal stromal tumor as most common).[7] Although leiomyoma is the most common benign esophageal tumor, malignant carcinoma is still 50 times more likely.[8] Approximately 50% of cases are found in the jejunum, followed by the ileum in 31% of cases. Almost one half of all lesions are less than 5 centimeters.[9]

Other locations, metastatic leiomyoma

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  • Metastatic leiomyoma are an extremely rare complication after surgery to remove the uterus for uterine fibroids. The most frequent sites of occurrence are the lungs and pelvis. The lesions are hormonally responsive.[10][11][12]
  • Fibromyoma of the breast is an extremely rare benign breast neoplasm. Most reports in literature mention a history of hysterectomy for uterine fibroids, although the question of whether these fibromyomas are possibly metastases of the uterine fibroids has not been investigated. An alternative hypothesis is an origin from the smooth muscle of the nipple.
  • Leiomyoma may spontaneously occur in any muscle. Depending on the location of the tumor, identification may not be timely until overall mass becomes undeniably noticeable. The symptoms for a 30-year-old male with a 10 cm leiomyoma included "dead leg" pains. Tumor was intertwined with quadriceps muscles, making identification and excision difficult. Tumor was successfully excised with only minor rehabilitation required.[13]

Familial leiomyoma

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See also

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References

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  1. ^ El Sabeh M, Saha SK, Afrin S, Islam MS, Borahay MA (2021). "Wnt/β-catenin signaling pathway in uterine leiomyoma: role in tumor biology and targeting opportunities". Mol Cell Biochem. 476 (9): 3513–3536. doi:10.1007/s11010-021-04174-6. PMC 9235413. PMID 33999334.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Pedeutour, F.; Quade, B. J.; Sornberger, K.; Tallini, G.; Ligon, A. H.; Weremowicz, S.; Morton, C. C. (2000). "Dysregulation ofHMGIC in a uterine lipoleiomyoma with a complex rearrangement including chromosomes 7, 12, and 14". Genes, Chromosomes and Cancer. 27 (2): 209–215. doi:10.1002/(SICI)1098-2264(200002)27:2<209::AID-GCC14>3.0.CO;2-U. PMID 10612811. S2CID 25287681.
  3. ^ McDonald, A. G.; Cin, P. D.; Ganguly, A.; Campbell, S.; Imai, Y.; Rosenberg, A. E.; Oliva, E. (2011). "Liposarcoma Arising in Uterine Lipoleiomyoma". The American Journal of Surgical Pathology. 35 (2): 221–227. doi:10.1097/PAS.0b013e31820414f7. PMID 21263242. S2CID 25445426.
  4. ^ Segura-Sampedro, J. J.; Alamo-Martínez, J. M.; Cañete-Gómez, J.; Suárez-Artacho, G.; González-Cantón, J. R.; Gómez-Bravo, M. Á.; Padillo-Ruiz, F. J. (2012). "Gallbladder leiomyoma in absence of immune system disorders: An unusual diagn". Revista Española de Enfermedades Digestivas. 104 (7): 382–384. doi:10.4321/S1130-01082012000700009. PMID 22849501.
  5. ^ Freedberg, Irwin M.; Fitzpatrick, Thomas B. (2003). Fitzpatrick's dermatology in general medicine (6th ed.). New York: McGraw-Hill, Medical Pub. Division. p. 1033. ISBN 0-07-138076-0.
  6. ^ Odom, Richard B.; Davidsohn, Israel; James, William D.; Henry, John Bernard; Berger, Timothy G.; Dirk M. Elston (2006). Andrews' diseases of the skin: clinical dermatology (10th ed.). Saunders Elsevier. p. 627. ISBN 0-7216-2921-0.
  7. ^ Radiologic Pathology Archives: Esophageal Neoplasms: Radiologic-Pathologic Correlation Rachel B. Lewis, Anupamjit K. Mehrotra, Pablo Rodriguez, and Marc S. Levine. RadioGraphics 2013 33:4, 1083-1108. Accessed 2017-07-08
  8. ^ Radiologic Pathology Archives: Esophageal Neoplasms: Radiologic-Pathologic Correlation Rachel B. Lewis, Anupamjit K. Mehrotra, Pablo Rodriguez, and Marc S. Levine. RadioGraphics 2013 33:4, 1083-1108. Accessed 2017-07-08
  9. ^ Michael P. Buetow, M.D. "Leiomyoma of Jejunum". Applied Radiology Online. Archived from the original on 2007-09-27. Retrieved 2007-03-21.
  10. ^ Patton, K.; Cheng, L.; Papavero, V.; Blum, M.; Yeldandi, A.; Adley, B.; Luan, C.; Diaz, L.; Hui, P.; Yang, X. J. (2006). "Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis". Modern Pathology. 19 (1): 130–140. doi:10.1038/modpathol.3800504. PMID 16357844.
  11. ^ Beck, M. M.; Biswas, B.; d'Souza, A.; Kumar, R. (2012). "Benign metastasising leiomyoma after hysterectomy and bilateral salpingo-oophorectomy". Hong Kong medical [Xianggang yi xue za zhi / Hong Kong Academy of Medicine]. 18 (2): 153–155. PMID 22477740.
  12. ^ Rivera, J. A.; Christopoulos, S.; Small, D.; Trifiro, M. (2004). "Hormonal Manipulation of Benign Metastasizing Leiomyomas: Report of Two Cases and Review of the Literature". Journal of Clinical Endocrinology & Metabolism. 89 (7): 3183–3188. doi:10.1210/jc.2003-032021. PMID 15240591.
  13. ^ Bulmer, J. H. (February 1967). "Smooth Muscle Tumours of the Limbs". The Journal of Bone and Joint Surgery. British Volume. 49-B (1): 52–58. doi:10.1302/0301-620X.49B1.52. ISSN 0301-620X.
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