Chondroid lipoma
| Chondroid lipoma | |
|---|---|
| Specialty | Dermatology |
Chondroid lipomas are deep-seated, firm, yellow tumors that characteristically occur on the legs of women. They exhibit a characteristic genetic translocation t(11;16) with a resulting C11orf95-MKL2 fusion oncogene.[1]: 625 [2]
Signs and symptoms
[edit]Chondroid lipoma is an uncommon soft tissue fatty tumor that can develop in deeper or superficial tissues. It often manifests as a painless mass.[3] The subcutis, superficial muscular fascia, or skeletal muscles of the limbs and limb girdles, trunk, head, and neck are where the majority of lesions are located.[4] They can grow to be quite large.[3]
Chondroid lipomas can also cause tenderness, tingling,[5] and radiating pain.[6] Polyps are the oral manifestation of chondroid lipoma,[7] whereas unexplained vaginal bleeding is the intrauterine manifestation.[8]
Diagnosis
[edit]From a histological perspective, chondroid lipomas are well-defined tumors that have mature adipocytes in regions resembling lipomas and a chondroid component that has vacuolated lipoblast-like cells encircled by myxohyaline matrix.[3]
The tumor cells stain for CD-68, Vimentin, and S-100 protein using immunohistochemistry. In certain situations, focal positive for keratin has been recorded.[9] Chondroid lipomas are genuinely biphenotypic, exhibiting characteristics of primitive cartilage and lipoblastic development, according to ultrastructural investigations.[10]
The differential diagnosis for chondroid lipoma includes chondrolipoma, extraskeletal chondroma, extraskeletal myxoid chondrosarcoma, myxoid liposarcoma, and lipoblastoma.[11]
Treatment
[edit]Simple lesion excision is the primary treatment for chondroid lipoma; adjuvant therapy is not necessary after surgery. Oral cavity and other sensitive areas can be treated using diode lasers for afflicted tissues. Compared to other procedures, this one has the advantages of not causing intraoperative bleeding, not requiring suturing, and having less bleeding, edema, and inflammation after surgery.[6]
Epidemiology
[edit]Although it typically manifests in the third or fourth decade of life, chondroid lipoma has a wide age distribution; two studies report similar age ranges of 16 to 70 years (median, 28 years)[12] and 14 to 70 years (median, 36 years),[4] with uncommon cases occurring in children under the age of ten.[13] There is a roughly 4:1 ratio of women to men, but no racial bias is seen.[14]
See also
[edit]References
[edit]- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
- ^ Genes Chromosomes Cancer. 2010 Sep;49(9):810-8. doi: 10.1002/gcc.20788. C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. Huang D1, Sumegi J, Dal Cin P, Reith JD, Yasuda T, Nelson M, Muirhead D, Bridge JA.
- ^ a b c Gokhale, Uday; Pillai, G. Rajasekharan; Varghese, P.V.; Samarsinghe, D. (2024-03-14). "Chondroid Lipoma: A Case Report". Oman Medical Journal. 23 (2). Oman Medical Specialty Board: 116–117. PMC 3282416. PMID 22379550.
- ^ a b Meis, J M; Enzinger, F M (November 1993). "Chondroid lipoma. A unique tumor simulating liposarcoma and myxoid chondrosarcoma". The American Journal of Surgical Pathology. 17 (11): 1103–1112. doi:10.1097/00000478-199311000-00003. PMID 8214255.
- ^ Park, Sang-Eun; Lee, Jung-Uee; Ji, Jong-Hun (2010-12-11). "Intraneural chondroid lipoma on the common peroneal nerve". Knee Surgery, Sports Traumatology, Arthroscopy. 19 (5). Wiley: 832–834. doi:10.1007/s00167-010-1343-6. ISSN 0942-2056. PMID 21153537.
- ^ a b Huang, Chao; Guo, Wenlai; Qu, Wenrui; Zhu, Zhe; Li, Rui (2019). "Characteristics of chondroid lipoma". Medicine. 98 (19). Ovid Technologies (Wolters Kluwer Health): e15587. doi:10.1097/md.0000000000015587. ISSN 0025-7974. PMC 6531192.
- ^ Villarroel Dorrego, M.; Papp, Y.; Shelley, M. J.; Barrett, A. W. (2013-07-31). "Chondroid lipoma of the tongue: a report of two cases". Oral and Maxillofacial Surgery. 18 (2). Springer Science and Business Media LLC: 219–222. doi:10.1007/s10006-013-0426-1. ISSN 1865-1550. PMID 23900485.
- ^ Blandamura, S; Florea, G; Chiarelli, S; Rondinelli, R; Ninfo, V (2005-04-19). "Myometrial leiomyoma with chondroid lipoma-like areas". Histopathology. 46 (5). Wiley: 596–598. doi:10.1111/j.1365-2559.2005.02023.x. ISSN 0309-0167. PMID 15842648.
- ^ Mentzel, T.; Remmler, K.; Katenkamp, D. (1999-11-10). "Chondroides Lipom". Der Pathologe. 20 (6). Springer Science and Business Media LLC: 330–334. doi:10.1007/s002920050366. ISSN 0172-8113. PMID 10591950.
- ^ Kindblom, Lars-Gunnar (2006). "Lipomatous Tumors—How We Have Reached Our Present Views, What Controversies Remain and Why We Still Face Diagnostic Problems". Advances in Anatomic Pathology. 13 (6). Ovid Technologies (Wolters Kluwer Health): 279–285. doi:10.1097/01.pap.0000213053.00060.5a. ISSN 1072-4109.
- ^ Mocellin, Simone (2021). "Chondroid Lipoma". Soft Tissue Tumors. Cham: Springer International Publishing. pp. 169–170. doi:10.1007/978-3-030-58710-9_50. ISBN 978-3-030-58709-3.
- ^ Kindblom, Lars-gunnar; Meis-kindblom, Jeanne M (1995). "Chondroid lipoma: An ultrastructural and immunohistochemical analysis with further observations regarding its differentiation". Human Pathology. 26 (7). Elsevier BV: 706–715. doi:10.1016/0046-8177(95)90217-1. ISSN 0046-8177. PMID 7628841.
- ^ Patne, ShashikantC.U; Aryya, Nc; Gangopadhyay, An (2008). "Chondroid lipoma in a child". Indian Journal of Pathology and Microbiology. 51 (4): 541–542. doi:10.4103/0377-4929.43755. ISSN 0377-4929. PMID 19008590.
- ^ Thway, Khin; Flora, Rashpal Singh; Fisher, Cyril (2012). "Chondroid lipoma: an update and review". Annals of Diagnostic Pathology. 16 (3). Elsevier BV: 230–234. doi:10.1016/j.anndiagpath.2012.01.002. ISSN 1092-9134. PMID 22607659.
Further reading
[edit]- Huang, Dali; Sumegi, Janos; Dal Cin, Paola; Reith, John D.; Yasuda, Taketoshi; Nelson, Marilu; Muirhead, David; Bridge, Julia A. (2010-05-25). "C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma". Genes, Chromosomes and Cancer. 49 (9). Wiley: 810–818. doi:10.1002/gcc.20788. ISSN 1045-2257. PMC 2904421. PMID 20607705.
- de Vreeze, Ronald S. A.; van Coevorden, Frits; Boerrigter, Lucie; Nederlof, Petra M.; Haas, Rick L.; Bras, Johannes; Rosenwald, Andreas; Mentzel, Thomas; de Jong, Daphne (2011). "Delineation of Chondroid Lipoma: An Immunohistochemical and Molecular Biological Analysis". Sarcoma. 2011. Hindawi Limited: 1–5. doi:10.1155/2011/638403. ISSN 1357-714X. PMC 3087950.