Latexin family
| Latexin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 human carboxypeptidase a4 in complex with human latexin. | |||||||||
| Identifiers | |||||||||
| Symbol | Latexin | ||||||||
| Pfam | PF06907 | ||||||||
| InterPro | IPR009684 | ||||||||
| MEROPS | I47 | ||||||||
| |||||||||
In molecular biology, the latexin family is a family of proteins which family consists of several animal specific latexin and proteins related to latexin that belong to MEROPS proteinase inhibitor family I47, clan IH.[1]
Latexin, a protein possessing inhibitory activity against rat carboxypeptidase A1 (CPA1) and CPA2 (MEROPS peptidase family M14A), is expressed in a neuronal subset in the cerebral cortex and cells in other neural and non-neural tissues of rat.[2][3] OCX-32, the 32 kDa eggshell matrix protein, is present at high levels in the uterine fluid during the terminal phase of eggshell formation, and is localised predominantly in the outer eggshell. The timing of OCX-32 secretion into the uterine fluid suggests that it may play a role in the termination of mineral deposition.[4] OCX-32 protein possesses limited identity (32%) to two unrelated proteins: latexin and to a skin protein that is encoded by a retinoic acid receptor-responsive gene, TIG1. Tazarotene Induced Gene 1 (TIG1) is a putative transmembrane protein with a small N-terminal intracellular region, a single membrane-spanning hydrophobic region, and a large C-terminal extracellular region containing a glycosylation signal. TIG1 is up-regulated by retinoic acid receptor but not by retinoid X receptor-specific synthetic retinoids.[5] TIG1 may be a tumour suppressor gene whose diminished expression is involved in the malignant progression of prostate cancer.[6]
References
[edit]- ^ Rawlings ND, Tolle DP, Barrett AJ (March 2004). "Evolutionary families of peptidase inhibitors". Biochem. J. 378 (Pt 3): 705–16. doi:10.1042/BJ20031825. PMC 1224039. PMID 14705960.
- ^ Uratani Y, Takiguchi-Hayashi K, Miyasaka N, Sato M, Jin M, Arimatsu Y (March 2000). "Latexin, a carboxypeptidase A inhibitor, is expressed in rat peritoneal mast cells and is associated with granular structures distinct from secretory granules and lysosomes". Biochem. J. 346 (3): 817–26. doi:10.1042/0264-6021:3460817. PMC 1220918. PMID 10698712.
- ^ Liu Q, Yu L, Gao J, Fu Q, Zhang J, Zhang P, Chen J, Zhao S (2000). "Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor". Mol. Biol. Rep. 27 (4): 241–6. doi:10.1023/A:1010971219806. PMID 11455960. S2CID 12632858.
- ^ Hincke MT, Gautron J, Mann K, Panheleux M, McKee MD, Bain M, Solomon SE, Nys Y (2003). "Purification of ovocalyxin-32, a novel chicken eggshell matrix protein". Connect. Tissue Res. 44 (Suppl 1): 16–9. doi:10.1080/03008200390152025. PMID 12952168. S2CID 45035402.
- ^ Nagpal S, Patel S, Asano AT, Johnson AT, Duvic M, Chandraratna RA (February 1996). "Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin". J. Invest. Dermatol. 106 (2): 269–74. doi:10.1111/1523-1747.ep12340668. PMID 8601727.
- ^ Jing C, El-Ghany MA, Beesley C, Foster CS, Rudland PS, Smith P, Ke Y (April 2002). "Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity". J. Natl. Cancer Inst. 94 (7): 482–90. doi:10.1093/jnci/94.7.482. PMID 11929948.