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Protein-coding gene in the species Homo sapiens
U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene .[ 5] [ 6]
This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is involved in the general maturation of RNA in the nucleus.[ 6]
LSM8 has been shown to interact with LSM2 .[ 7] [ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000128534 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044155 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro" . EMBO J . 18 (20): 5789–802. doi :10.1093/emboj/18.20.5789 . PMC 1171645 . PMID 10523320 .
^ a b "Entrez Gene: LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)" .
^ Lehner, Ben; Sanderson Christopher M (Jul 2004). "A protein interaction framework for human mRNA degradation" . Genome Res . 14 (7): 1315–23. doi :10.1101/gr.2122004 . ISSN 1088-9051 . PMC 442147 . PMID 15231747 .
^ Lehner, Ben; Semple Jennifer I; Brown Stephanie E; Counsell Damian; Campbell R Duncan; Sanderson Christopher M (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics . 83 (1): 153–67. doi :10.1016/S0888-7543(03)00235-0 . ISSN 0888-7543 . PMID 14667819 .
Khusial P, Plaag R, Zieve GW (2005). "LSm proteins form heptameric rings that bind to RNA via repeating motifs". Trends Biochem. Sci . 30 (9): 522–8. doi :10.1016/j.tibs.2005.07.006 . PMID 16051491 .
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Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera" . Arthritis Rheum . 46 (3): 726–34. doi :10.1002/art.10220 . PMID 11920408 .
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Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation" . Genome Res . 14 (7): 1315–23. doi :10.1101/gr.2122004 . PMC 442147 . PMID 15231747 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
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