LETM1-like protein family
| LETM1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | LETM1 | ||||||||
| Pfam | PF07766 | ||||||||
| InterPro | IPR011685 | ||||||||
| TCDB | 8.A.20 | ||||||||
| |||||||||
LETM1-like is a family of evolutionarily related proteins. This is a group of mainly hypothetical eukaryotic proteins. Putative features found in LETM1, such as a transmembrane domain and a CK2 and PKC phosphorylation site,[1] are relatively conserved throughout the family. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans.[1] A member of this family, SWISSPROT, is known to be expressed in the mitochondria of Drosophila melanogaster,[2] suggesting that this may be a group of mitochondrial proteins.
Examples
[edit]Human gene encoding members of this family include:
References
[edit]- ^ a b Endele S, Fuhry M, Pak SJ, Zabel BU, Winterpacht A (September 1999). "LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients". Genomics. 60 (2): 218–25. doi:10.1006/geno.1999.5881. PMID 10486213.
- ^ Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, Barsanti P (February 1999). "Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database". Mol. Gen. Genet. 261 (1): 64–70. doi:10.1007/s004380050942. PMID 10071211. S2CID 23811774.