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Klaus Mosbach
Klaus Mosbach
Born(1932-11-26)26 November 1932
Leipzig, Saxony, Germany
Died22 January 2024(2024-01-22) (aged 91)
Malmö, Sweden
OccupationSwedish Applied biochemist

Klaus Hermann Mosbach (26 November 1932 – 22 January 2024) was a Swedish applied biochemist based at Lund University. He founded the Center for Molecular Imprinting in Lund, Sweden and was co-founder of the Institute of biotechnology at ETH Zurich Switzerland 1982.[1][2][3][4] He was a great visionary who gave shape to the modern era of Molecular imprinting for which he was awarded the plaque at the international meeting of molecular imprinting in 2010 in New Orleans, United States.

Biography

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Born 1932, Leipzig, Germany[5]
Died 2024, Malmö, Sweden[6][7]
Citizenship Swedish.[5]
Field Biochemistry.[5]
Institution Lund University, Sweden.[5]
other Institution ETH Zurich.[5]
Known for Molecular imprinting, Enzyme immobilization, Affinity chromatography
Notable awards Enzyme engineering award by Engineering foundation, USA.[8]

Gold medalist of Royal Swedish Academy of Engineering Sciences.[8]

Pierce Award by International organization of Affinity chromatography and Biorecognition.[9]

He was a great visionary who gave shape to the modern era of Molecular imprinting for which he has been awarded the plaque at the international meeting of molecular imprinting in 2010 in New Orleans, United States of America.[9]

Early life and education

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Klaus Mosbach was born in Leipzig, Germany.[5][10] Family status: Married to May E., three daughters (Petra, Katja, Vanja).[5][10] Klaus Mosbach went to school in Leipzig Germany and Lund, Sweden, In 1952 he moved to London, where he took Cambridge and interpreter exams.[10] After working in a pharmaceutical company, Ferrosan in Malmö, Sweden, he began his university studies at Lund University 1953. In 1956 he took his master's degree in chemistry and biology and subsequently in 1960 his Ph.D. in biochemistry with a thesis on "the biosynthesis of aromatic compounds in fungi and lichens".[11] He was then awarded the Waksman-Merck post-doctoral fellowship and stayed for 1.5 years at the Institute of Microbiology, Rutgers University, N.J., USA...[5][10] In 1962 he developed, jointly with Dr. Schaffner in the Philippines, a pasteurization process against Salmonella infections in coconuts, which subsequently was approved by the Food and Drug Administration and is presently used. After returning to Sweden, he continued his studies on secondary metabolism.[10] He received his second Ph.D. (corresponding to associate professorship or "Habilitation") from the University of Lund in 1964. Until 1970 he was associate professor there, and from 1970 onwards he has been full professor and head of the Department of Pure and Applied Biochemistry, which he founded, at Lund Institute of Technology. He also co-founded the Department of biotechnology at the Swiss Federal Institute of Technology ETH Zurich, Switzerland, in 1982.[4]

Positions held

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Professor Mosbach had leaves to take advantage of the following positions

During these stays he collaborated with Nobel Prize winners Lynen, Waksman as well as with Professors Estabrook and Srere, Katchalski-Katzir and Wilchek, Fukui, Chibata, Suzuki, Rees and Creighton respectively.[10]

Co-Workers

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Klaus Mosbach had the pleasure of essentially wholly supervising more than sixty Ph.D.’s over the years...[10][14] A number of highly recognized scientists emerged from this pool, including the following professors C. Borrebaeck (in part), B.Sellergren (who is now a professor in Germany).[15] P. Brodelius, Leif Bulow, B. Danielsson, B. Hahn-Hägerdahl (in part), A.C. Koch. Schmidt, P.O. Larsson, C. F. Mandenius, B. Mattiasson, M.O. Månsson, I.A. Nicholls (starting as post doc), R. Ohlsson (in part), Lei Ye and S. Olsson working all in Sweden. To this a number of Professors working in other countries outside Sweden including, L.Fischer, K. Haupt, C.Lowe, H.Zhang, Deepak Chandrasekaran. [16][14][17]

Mosbach collaborated with numerous companies over the years, including Biogen and later Hybritech, Eli Lilly, Igen, Hofman la Roche and was involved in the formation of start-up companies by himself likewise former students of him have been successful in starting up companies like B.Ekberg, N.Siegbahn, Kurt Nilsson, Kjell Nilsson, Dariao Kriz.

Selected awards

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  • From 1981 member of the European Molecular Biology Organization (EMBO).[18]
  • From 1982 honorary member of the American Society for Biochemistry and Molecular Biology.[12]
  • Received the Arrhenius Medal in 1983.[19]
  • From 1985 member of the Protein Society, USA.
  • 1985 he was awarded two highly esteemed international scientific prizes given every second year, covering different major areas in biotechnology/biochemistry) as listed below:
  1. In Enzyme Engineering by the Engineering Foundation, New York, USA, "in recognition of outstanding contributions to the field of enzyme engineering".[8](previous winners: Dr. Chibata, subsequent to him Professors Katchalski-Katzir, Fukui, Klibanov, Lilly, Kula/Wandrey (jointly)).
  2. For "important contributions in the field of affinity chromatography" by the International Organization on Affinity Chromatography and Biorecognition (first winner K. Mosbach followed by M. Wilchek (1989), C.R. Lowe (1991), I.M. Chaiken (1993), J. Porath (1995), Regnier/Uhlén (1997) (jointly), Kasai (1999) and Vijayalaksmi (2001)...[8][20]
  • In 1990 he was awarded the gold medal of the Royal Swedish Academy of Engineering Sciences for his contribution to biotechnology, especially on the immobilization of bioactive substances.[8]
  • In 1993 he was awarded the research prize by the Swedish Fund for "Research without Animal Experiments".
  • In April 1999, Biogen Inc., together with its early members including Klaus Mosbach, received the US National Gold Medal of Technology. The recipient of this award was selected by the Department of Commerce and presented by the president William J. Clinton.[8]
  • In October 2002 at the International Symposium on Chromatography in London, Klaus Mosbach was presented the Martin Gold Medal, at the Royal Society, for the year 2000, by the Executive Committee of the Chromatographic Society. It was awarded him "in recognition of his major contributions to the field of separation science over many years". Previous recipients of this award are inter alia F. Regnier (1993), C. Horvath (1994) and W.H. Pirkle (1990).[21]
  • Mosbach published more than 537 peer reviewed scientific articles and reviews with an H-Index of 77.[21][22]
  • Mosbach wrote and edited four volumes of methods in enzymology series on Immobilized Enzymes, by Academic press (44,132,133,134).[21]
  • In addition he has received and applied for 84 patents.[21]

References

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  1. ^ Lacy, Sarah (21 July 2006), "Do-It-Yourself Decaf", BusinessWeek, archived from the original on 16 August 2006
  2. ^ ETH Zurich
  3. ^ a b "ETHistory - Page not found". ethz.ch. {{cite web}}: Cite uses generic title (help)
  4. ^ a b Mosbach, Klaus (2006). "The Promise Of Molecular Imprinting". Scientific American. 295 (4): 86–91. Bibcode:2006SciAm.295d..86M. doi:10.1038/scientificamerican1006-86 (inactive 1 November 2024). PMID 16989485.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
  5. ^ a b c d e f g h http://www.mendeley.com/research/molecularly-imprinted-polymers-biomimetic-sensors-1/#[permanent dead link]
  6. ^ "Klaus Hermann Mosbach". ratsit. Retrieved 4 February 2024.
  7. ^ "A few days ago, I received the sad news that Prof. Dr. Klaus Mosbach, born in Leipzig in 1932, has passed away at the age of 91". Prof. Dr. Oliver Brüggemann on LinkedIn. Retrieved 4 February 2024.
  8. ^ a b c d e f "Biochemical Technology, Part A". Bokus.com.
  9. ^ a b "Awards". ismr.org. Archived from the original on 16 August 2015. Retrieved 19 June 2015.
  10. ^ a b c d e f g h i j k "Klaus Mosbach Homepage". Archived from the original on 29 January 2011. Retrieved 2 February 2011.
  11. ^ Mosbach, K. (1969). "Biosynthesis of Lichen Substances, Products of a Symbiotic Association". Angewandte Chemie International Edition in English. 8 (4): 240–250. doi:10.1002/anie.196902401.
  12. ^ a b c d Masters, Bettie Sue Siler (24 July 2009). "A Professional and Personal Odyssey". Journal of Biological Chemistry. 284 (30): 19765–19780. doi:10.1074/jbc.X109.007518. PMC 2740401. PMID 19398561.
  13. ^ a b c d e f g h Haupt, Karsten; Mosbach, Klaus (21 June 2000). "Molecularly Imprinted Polymers and Their Use in Biomimetic Sensors". Chem. Rev. 100 (7): 2495–2504. doi:10.1021/cr990099w. PMID 11749293.
  14. ^ a b Bulow, L. (6 May 1997). Biochemical Technology. Elsevier. ISBN 9780080876979.
  15. ^ "PD Dr. Börje Sellergren | AK Sellergren". Archived from the original on 27 September 2008. Retrieved 19 June 2015.
  16. ^ "Company Directory".
  17. ^ "Klaus Mosbach Homepage". Archived from the original on 26 October 2017. Retrieved 17 May 2019.
  18. ^ "masthead" (PDF). EMBO J. 1 (1). 1982. PMC 552983.
  19. ^ Burlingame, A. L.; Baillie, Thomas A.; Derrick, Peter J. (April 1986). "Mass spectrometry". Analytical Chemistry. 58 (5): 165–211. doi:10.1021/ac00296a015. PMID 3521386.
  20. ^ "Awards". ismr.org. Archived from the original on 25 April 2012. Retrieved 2 November 2011.
  21. ^ a b c d "Biokemin ersatte flygeln" (PDF). LTH-nytt (in Swedish). No. 1. Summer 2007. p. 14. Retrieved 21 May 2023.
  22. ^ http://www.klaus[permanent dead link] Mosbach.com
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