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Kazutoshi Mori

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Kazutoshi Mori
森 和俊
Kazutoshi Mori
Born (1958-07-07) 7 July 1958 (age 66)
Kurashiki, Okayama
NationalityJapanese
Alma materKyoto University
Known forUnfolded protein response
AwardsWiley Prize in Biomedical Science (2005)
Gairdner Award (2009)
Shaw Prize (2014)
Lasker Award (2014)
Imperial Prize (2016)
Breakthrough Prize in Life Sciences (2018)
Keio Medical Science Prize (2023)
Scientific career
FieldsMolecular biology
Cell biology
InstitutionsKyoto University

Kazutoshi Mori (森 和俊, Mori Kazutoshi, born 1958) is a Japanese molecular biologist known for research on unfolded protein response. He is a professor of Biophysics at the Graduate School of Science, Kyoto University,[1] and shared the 2014 Albert Lasker Basic Medical Research Award with Peter Walter for discoveries concerning the unfolded protein response — an intracellular quality control system that detects harmful misfolded proteins in the endoplasmic reticulum and signals the nucleus to carry out corrective measures.[2]

Early life and education

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Mori was born in 1958 in Kurashiki, Okayama. In the elementary school era, he was good at mathematics and arithmetic, and learned from the newspaper about the existence of quarks. In the middle school era, he was influenced by the Nobel Prize in Physics of Hideki Yukawa, and he decided to study physics at the Faculty of Science at Kyoto University (at the time, the golden age of elementary particle physics). However, he was finally admitted to the Department of Synthetic Chemistry of the Faculty of Engineering at Kyoto University.[3]

When Mori was in the first year of college, he did not understand the significant difference between the laws of physics and chemistry, but he learned about the new development of molecular biology from newspaper articles. Soon after, Kyoto University alumnus Susumu Tonegawa made a breakthrough in immunology research (which earned Tonegawa the first Japanese Nobel Prize in Physiology or Medicine about a decade later), Mori read about it in the newspaper and was shocked, then he decided to transfer to the Faculty of Pharmaceutical Sciences and continue to pursue graduate studies. In 1985, he obtained a doctorate degree.[3]

Career

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A simplified diagram of the initiation of the UPR by prolonged and overwhelming protein misfolding

Mori was appointed as an assistant professor at Gifu Pharmaceutical University in 1985, before becoming a postdoctoral fellow at the University of Texas Southwestern Medical Center in 1989, and he began research on unfolded protein response (UPR) in the United States. He was a researcher at the HSP (Heat Shock Protein) Research Institute in Kyoto from 1993 to 1999, and has been a member of the faculty of Kyoto University since 1999.[4] Meanwhile, he completed the copying of HAC1, ATF6 and BP1.

The independent works of Mori and Peter Walter during the same period revealed the UPR pathway, which explains the mechanism by which cells generate signals due to stress and regulate. They discovered the inositol-requiring enzyme 1 (Ire1) in 1993, which communicates the state of the endoplasmic reticulum protein production line. These research uncovered to form the basis for understanding and treating a wide range of important diseases such as cancer, metabolic disorders including obesity, diabetes, fatty liver and dyslipidemia, a number of neurodegenerative diseases, and inflammatory diseases.

In 2003, Mori was transferred to the Department of Biophysics (Division of Biological Sciences) of Graduate School of Science at Kyoto University, the academic unit is also the first laboratory for molecular biology in Japan and has a long history.

Recognition

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Personal life

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Mori obtained the qualification of the fifth section of Kendo in 1998. He also briefly taught Kendo in elementary school (when his son attended the school at the time).[12]

References

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  1. ^ "Department of Biophysics, Kyoto University". Archived from the original on 18 July 2017. Retrieved 13 December 2021.
  2. ^ "Current Winners". Albert Lasker Basic Medical Research Award. Lasker Foundation. 2014. Archived from the original on 14 February 2016. Retrieved 16 January 2015.
  3. ^ a b INC, SANKEI DIGITAL (24 September 2015). "【関西の議論】ノーベル賞まであと一歩に迫る男、山中教授と同じラスカー賞獲得 ライバルとデッドヒート". 産経ニュース. Retrieved 13 December 2021.
  4. ^ "森研究室 » 京都大学大学院 理学研究科 生物科学専攻 生物物理学教室". www.upr.biophys.kyoto-u.ac.jp. Retrieved 13 December 2021.
  5. ^ "Wiley: Past Winners of the Wiley Prize in Biomedical Sciences". www.wiley.com. Retrieved 13 December 2021.
  6. ^ "Kazutoshi Mori". archive.ph. 15 April 2013. Archived from the original on 15 April 2013. Retrieved 13 December 2021.
  7. ^ "Announcement Press Conference". The Shaw Prize. The Shaw Prize Foundation. 2014. Archived from the original on 28 September 2018. Retrieved 4 June 2014.
  8. ^ "Kazutoshi Mori Wins 2018 Breakthrough Prize". Asian Scientist. 4 December 2017. Retrieved 5 January 2018.
  9. ^ "過去の受賞者". 安藤スポーツ･食文化振興財団. Retrieved 13 December 2021.[permanent dead link]
  10. ^ 第28回（2023年）受賞者
  11. ^ BBVA Foundation Frontiers of Knowledge Award 2023
  12. ^ "森研究室 » 京都大学大学院 理学研究科 生物科学専攻 生物物理学教室". www.upr.biophys.kyoto-u.ac.jp. Retrieved 13 December 2021.
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