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Katrin Rittinger

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Katrin Rittinger
Known forStudy of Ubiquitination
AwardsEMBO member
Scientific career
FieldsStructural Biology
Thesis Einsatz von intrinsischer and extrinsischer Fluoreszenz zur Untersuchung von Struktur-Funktionsbeziehungen an der HIV Reversen Transkriptase

Katrin Rittinger is a professor in structural biology who has made significant contributions to the ubiquitination field.[1] She is a senior scientist at the Francis Crick Institute and was awarded European Molecular Biology Organization (EMBO) membership in 2019.[2][3][4] Rittinger is on the Editorial Board of Biochemical Journal and has written on transparency and openness in science.[5][6]

Education and academic career

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Katrin Rittinger studied for a degree in chemistry at the Ruprecht Karls University, Heidelberg. Her Ph.D. research was at the Max-Planck Institute for Medical Research in Heidelberg with Roger Goody. In 1995 Rittinger moved to become a Postdoctoral Fellow at Max-PIanck Institute for Molecular Physiology, Dortmund. In 1996, Rittinger moved to London to the MRC National Institute for Medical Research working with Guy Dodson and Alastair Aitken. In 2000 Rittinger set up her independent group at the MRC National Institute for Medical Research (now part of the Francis Crick Institute).

Research interests

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During her Ph.D, Rittinger studied human immunodeficiency virus reverse transcriptase.[7][8] At MRC National Institute for Medical Research Rittinger studied the structural basis of the interaction between 14-3-3 proteins and phosphorylated target proteins.[9] At the same time she researched members of the Rho-family of GTPases and clarified the mechanism of action of GTPase-activating proteins (GAPs).[10] Latterly, Rittinger has studied the ubiquitination-dependent regulation of immune signalling processes.[11] She has also collaborated with GlaxoSmithKline to discover inhibitors targeting the active site cysteine of thioester-forming E3 ubiquitin ligases.[12]

Rittinger has undertaken activities to promote women in science.[13][14][15]

Professional associations and awards

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  • Katrin Rittinger is an associate editor of Biochemical Journal [5]
  • In 2015 Rittinger was nominated to AcademiaNet by the MRC[16]
  • In 2019 Rittinger was awarded EMBO membership[3][4][17]

References

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  1. ^ "College Directory| Imperial College London". www.imperial.ac.uk. Retrieved 2019-10-14.
  2. ^ "Katrin Rittinger". Crick. Retrieved 2019-10-13.
  3. ^ a b "Find people in the EMBO Communities". people.embo.org. Retrieved 2019-10-13.
  4. ^ a b "EMBO welcomes new Crick members". Crick. Retrieved 2019-10-13.
  5. ^ a b "Editorial Board". portlandpress.com. Retrieved 2019-10-13.
  6. ^ Sanders, Jeremy; Blundy, Jon; Donaldson, Anne; Brown, Steve; Ivison, Rob; Padgett, Miles; Padian, Kevin; Rittinger, Katrin; Rowe, Kerry; Stace, Anthony; Viding, Essi (2017). "Transparency and openness in science". Royal Society Open Science. 4 (1): 160979. Bibcode:2017RSOS....460979S. doi:10.1098/rsos.160979. PMC 5319360. PMID 28280594.
  7. ^ Rittinger, K; Divita, G; Goody, R S (1995-08-15). "Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors". Proceedings of the National Academy of Sciences of the United States of America. 92 (17): 8046–8049. Bibcode:1995PNAS...92.8046R. doi:10.1073/pnas.92.17.8046. ISSN 0027-8424. PMC 41283. PMID 7544013.
  8. ^ Divita, Gilles; Baillon, Jean G.; Rittinger, Katrin; Chermann, Jean-Claude; Goody, Roger S. (1995-12-01). "Interface Peptides as Structure-based Human Immunodeficiency Virus Reverse Transcriptase Inhibitors". Journal of Biological Chemistry. 270 (48): 28642–28646. doi:10.1074/jbc.270.48.28642. ISSN 0021-9258. PMID 7499382.
  9. ^ Yaffe, Michael B.; Rittinger, Katrin; Volinia, Stefano; Caron, Paul R.; Aitken, Alastair; Leffers, Henrik; Gamblin, Steven J.; Smerdon, Stephen J.; Cantley, Lewis C. (1997-12-26). "The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity". Cell. 91 (7): 961–971. doi:10.1016/S0092-8674(00)80487-0. ISSN 0092-8674. PMID 9428519. S2CID 14107687.
  10. ^ Rittinger, Katrin; Walker, Philip A.; Eccleston, John F.; Smerdon, Stephen J.; Gamblin, Steven J. (1997). "Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue". Nature. 389 (6652): 758–762. Bibcode:1997Natur.389..758R. doi:10.1038/39651. ISSN 1476-4687. PMID 9338791. S2CID 4348794.
  11. ^ Walden, Helen; Rittinger, Katrin (2018). "RBR ligase–mediated ubiquitin transfer: a tale with many twists and turns" (PDF). Nature Structural & Molecular Biology. 25 (6): 440–445. doi:10.1038/s41594-018-0063-3. ISSN 1545-9985. PMID 29735995. S2CID 13680072.
  12. ^ Johansson, Henrik; Isabella Tsai, Yi-Chun; Fantom, Ken; Chung, Chun-Wa; Kümper, Sandra; Martino, Luigi; Thomas, Daniel A.; Eberl, H. Christian; Muelbaier, Marcel; House, David; Rittinger, Katrin (2019-02-13). "Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP". Journal of the American Chemical Society. 141 (6): 2703–2712. doi:10.1021/jacs.8b13193. ISSN 0002-7863. PMC 6383986. PMID 30657686.
  13. ^ "Mill Hill Essays | MRC National Institute for Medical Research, London". 2014-10-13. Archived from the original on 2014-10-13. Retrieved 2019-10-15.
  14. ^ "Remembering DNA Scientist Rosalind Franklin on Her Birthday, July 25". Retrieved 2019-10-13.
  15. ^ Institute, Babraham (2019-08-14). "8 things we learnt from lunch with Katrin Rittinger". Babraham Institute. Retrieved 2019-10-15.
  16. ^ "Dr. Katrin Rittinger - AcademiaNet". www.academia-net.org. Retrieved 2019-10-13.
  17. ^ Medical Research Council, M. R. C. (2019-07-19). "EMBO recognises outstanding MRC researchers". mrc.ukri.org. Retrieved 2019-10-14.


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