Kathrin Muegge

Kathrin Muegge
Alma mater	Hannover Medical School (MD)
Scientific career
Fields	Molecular biology, epigenetics, cancer research
Institutions	Frederick National Laboratory for Cancer Research

Kathrin Muegge is a German physician and molecular biologist researching chromatin organization during embryonic development and in tumor progression. She is a senior investigator and head of the epigenetics section at the Frederick National Laboratory for Cancer Research.

Education

Kathrin Muegge obtained a M.D. degree at the Hannover Medical School. As a postdoctoral researcher, she worked on cytokines and T cell development in the National Cancer Institute (NCI) Laboratory of Molecular Immunoregulation of Joost J. Oppenheim and Scott K. Durum.

Career and research

Muegge in October 1995

As a principal investigator at the Frederick National Laboratory for Cancer Research she investigates in the Laboratory of Cancer Prevention chromatin organization during embryonic development and in tumor progression. She is a senior investigator in the mouse cancer genetics program and head of the epigenetics section.

Muegge studies molecular mechanisms that alter chromatin structure and function during murine development. She discovered several links between chromatin modifiers, including nucleosomal remodeling and DNA methylation. The work focuses on chromatin changes during normal cellular differentiation and during the reverse process of nuclear reprogramming. Her studies provide insights how stable gene expression is achieved, how cells maintain a proper phenotype, and how this process may be disturbed in pathologic conditions including cancer.

References

 This article incorporates public domain material from websites or documents of the National Institutes of Health.

External links

• Media related to Kathrin Muegge at Wikimedia Commons