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Kaitlyn Sadtler

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Kaitlyn Sadtler
NationalityAmerican
Alma materUniversity of Maryland, Baltimore County (BS)
Johns Hopkins University (PhD)
Known forUS SARS-CoV-2 serosurvey
Scientific career
FieldsImmunology
Biomedical engineering
InstitutionsNational Institute of Biomedical Imaging and Bioengineering
ThesisTh2 T-cells are required for biomaterial-mediated functional muscle regeneration (2016)
Doctoral advisorJennifer Elisseeff

Kaitlyn Noelle Sadtler is an American immunologist and bioengineer and Stadtman tenure-track Investigator at the National Institute of Biomedical Imaging and Bioengineering, known for her research on immune-active biomaterials for regenerative medicine[1][2][3][4][5][6][7] and for completing the first population-wide serosurvey during the COVID-19 pandemic in the United States in 2020.[8][9]

Education

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Sadtler attended Urbana High School in Ijamsville, Maryland.[10] She went on to earn her BS in biomedical science summa cum laude at University of Maryland, Baltimore County (UMBC) in 2011.[11] She credits her undergraduate engineering experience with giving her a wide view of the different fields that are foundational to her current work.[12] Sadtler is among a cohort of researchers including Kizzmekia Corbett from UMBC who rose to prominence in the COVID-19 pandemic.[13][14]

Before starting her PhD, Sadtler held a one-year postbaccalaureate research position at the National Institute of Allergy and Infectious Diseases, where she says she "caught the immunology bug."[8] Sadtler worked in the laboratory of Jennifer Elisseeff at the Johns Hopkins University Cellular and Molecular Medicine program for her PhD, which she completed in only three and a half years, focusing on the molecular mechanisms of medical device fibrosis.[8][15] Parts of her thesis work were published in journals such as Science and Nature Methods.[15]

Career

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Sadtler was a postdoctoral fellow with Robert S. Langer and Daniel Anderson at the Massachusetts Institute of Technology, where she focused on how the modulation of immune response influenced tissue development.[16][17] During her postdoc, Sadtler was recognized as a TED fellow for her talk "How we could teach our bodies to heal faster."[18] She was also named an inaugural (2018) Convergence Scholar for her work in nanomedicine by the Koch Institute[19] and honored as one of the Forbes 30 Under 30 in 2019 for her doctoral research on immune rejection of medical devices.[20]

SARS-CoV-2 serosurvey

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Sadtler organized the first population-wide serosurvey for COVID-19 in the United States, considered critical in developing an understanding of asymptomatic transmission rates.[21] From April to July 2020, her group and collaborators enrolled 10,000 representative volunteers to mail in dry blood samples for testing by ELISA.[22][23] Initial testing of those samples was completed by the end of September.[12] Sadtler's team was able to sample a representative portion of the US population in part thanks to the overwhelming response of more than 400,000 volunteers for participation.[24] The initial analysis, released as a preprint in early 2021, indicated that there may have been as many as 4.8 unreported infections for each documented infection early in the pandemic, or up to 16.8 million undiagnosed infection.[25][26][27] Results also supported that black and Hispanic communities have been most affected by the virus.[28] Although the study is still undergoing peer-review, Sadtler explained her hopes for eventual follow-up to assess both antibody duration and reinfection frequency.[22][29]

References

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  1. ^ "Kaitlyn Sadtler, Ph.D. | Principal Investigators | NIH Intramural Research Program". irp.nih.gov. Retrieved 2024-10-23.
  2. ^ Sadtler, Kaitlyn. "Kaitlyn Sadtler | Speaker | TED". www.ted.com. Retrieved 2024-10-23.
  3. ^ Sadtler, Kaitlyn; Estrellas, Kenneth; Allen, Brian W.; Wolf, Matthew T.; Fan, Hongni; Tam, Ada J.; Patel, Chirag H.; Luber, Brandon S.; Wang, Hao; Wagner, Kathryn R.; Powell, Jonathan D.; Housseau, Franck; Pardoll, Drew M.; Elisseeff, Jennifer H. (2016-04-15). "Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells". Science. 352 (6283): 366–370. doi:10.1126/science.aad9272. ISSN 0036-8075. PMC 4866509. PMID 27081073.
  4. ^ Sadtler, Kaitlyn; Wolf, Matthew T.; Ganguly, Sudipto; Moad, Christopher A.; Chung, Liam; Majumdar, Shoumyo; Housseau, Franck; Pardoll, Drew M.; Elisseeff, Jennifer H. (2019-02-01). "Divergent immune responses to synthetic and biological scaffolds". Biomaterials. 192: 405–415. doi:10.1016/j.biomaterials.2018.11.002. ISSN 0142-9612.
  5. ^ Sadtler, Kaitlyn; Singh, Anirudha; Wolf, Matthew T.; Wang, Xiaokun; Pardoll, Drew M.; Elisseeff, Jennifer H. (2016-06-07). "Design, clinical translation and immunological response of biomaterials in regenerative medicine". Nature Reviews Materials. 1 (7): 1–17. doi:10.1038/natrevmats.2016.40. ISSN 2058-8437.
  6. ^ Sadtler, Kaitlyn; Allen, Brian W.; Estrellas, Kenneth; Housseau, Franck; Pardoll, Drew M.; Elisseeff, Jennifer H. (October 2017). "The Scaffold Immune Microenvironment: Biomaterial-Mediated Immune Polarization in Traumatic and Nontraumatic Applications". Tissue Engineering Part A. 23 (19–20): 1044–1053. doi:10.1089/ten.tea.2016.0304. ISSN 1937-3341. PMC 6436021. PMID 27736323.
  7. ^ Sadtler, Kaitlyn; Sommerfeld, Sven D.; Wolf, Matthew T.; Wang, Xiaokun; Majumdar, Shoumyo; Chung, Liam; Kelkar, Dhanashree S.; Pandey, Akhilesh; Elisseeff, Jennifer H. (2017-02-01). "Proteomic composition and immunomodulatory properties of urinary bladder matrix scaffolds in homeostasis and injury". Seminars in Immunology. SI: Innate immunity and biologic scaffolds. 29: 14–23. doi:10.1016/j.smim.2017.05.002. ISSN 1044-5323. PMC 8509637.
  8. ^ a b c "Engineering tissues and a new science culture | National Institute of Biomedical Imaging and Bioengineering". www.nibib.nih.gov. Retrieved 2021-03-19.
  9. ^ DeVille, Taylor. "Almost 17 million U.S. coronavirus cases were not detected during first half of 2020, study led by UMBC graduate finds". baltimoresun.com. Retrieved 2021-03-19.
  10. ^ Lynn, Kellye (2020-05-18). "Former Frederick County student researching COVID-19 antibodies at NIH". WJLA. Retrieved 2021-03-19.
  11. ^ "Meet Dr. Kaitlyn Sadtler, an immunoengineer working on how our body's defense system can help build new tissue!". The female Scientist. 2018-02-25. Retrieved 2021-03-19.
  12. ^ a b Hansen, Sarah (2020-11-17). "Chasing Antibodies". UMBC Magazine. Retrieved 2021-03-19.
  13. ^ Dzirasa, Letitia Dzirasa, Delali. "It's time to expand affordable high-quality higher ed at places like UMBC that have a proven track | COMMENTARY". baltimoresun.com. Retrieved 2021-03-19.{{cite web}}: CS1 maint: multiple names: authors list (link)
  14. ^ Hrabowski, Freeman A.; Tracy, J. Kathleen; Henderson, Peter H. (2020-08-04). "Opinion: At a Crossroads: Reimagining science, engineering, and medicine—and its practitioners". Proceedings of the National Academy of Sciences. 117 (31): 18137–18141. doi:10.1073/pnas.2013588117. ISSN 0027-8424. PMC 7414165. PMID 32669431.
  15. ^ a b "Kaitlyn Sadtler | National Institute of Biomedical Imaging and Bioengineering". www.nibib.nih.gov. Retrieved 2021-03-19.
  16. ^ "Publications: 2011 – 2020 – Langer Lab". Retrieved 2021-03-19.
  17. ^ "Kaitlyn Sadtler". The Marble Center for Cancer Nanomedicine. Retrieved 2021-03-19.
  18. ^ Sadtler, Kaitlyn, How we could teach our bodies to heal faster, retrieved 2021-03-19
  19. ^ "Preparing postdocs for life beyond the bench". MIT News | Massachusetts Institute of Technology. Retrieved 2021-03-19.
  20. ^ "Kaitlyn Sadtler". Forbes. Retrieved 2021-03-19.
  21. ^ Rosenbaum, Leah. "This 30 Under 30 Alum Is Figuring Out How Many People Already Have Immunity Against Coronavirus". Forbes. Retrieved 2021-03-19.
  22. ^ a b DeVille, Taylor. "Almost 17 million U.S. coronavirus cases were not detected during first half of 2020, study led by UMBC graduate finds". baltimoresun.com. Retrieved 2021-03-19.
  23. ^ Albert, Mark (2020-04-16), Want to know if you have immunity from the coronavirus? A new study seeks volunteers, retrieved 2021-03-19
  24. ^ Perera, Katryna. "Kaitlyn Sadtler: FCPS grad turned COVID-19 researcher". The Frederick News-Post. Retrieved 2021-03-19.
  25. ^ Kalish, Heather; Klumpp-Thomas, Carleen; Hunsberger, Sally; Baus, Holly Ann; Fay, Michael P.; Siripong, Nalyn; Wang, Jing; Hicks, Jennifer; Mehalko, Jennifer; Travers, Jameson; Drew, Matthew (2021-01-31). "Mapping a Pandemic: SARS-CoV-2 Seropositivity in the United States". medRxiv 10.1101/2021.01.27.21250570.
  26. ^ Times, Amina Khan, Los Angeles. "Pandemic's reach far outstripped official coronavirus case counts, study suggests". Finger Lakes Times. Retrieved 2021-03-19.{{cite web}}: CS1 maint: multiple names: authors list (link)
  27. ^ "Millions of coronavirus cases likely went undiagnosed". CBS News. 2021-02-22. Retrieved 13 November 2024.
  28. ^ "Biden striving for return to normalcy by end of year | Health and Science | Journal Gazette". www.journalgazette.net. Retrieved 2021-03-19.
  29. ^ Rosenbaum, Leah. "Researchers Estimate There Were 17 Million Undiagnosed Cases Of Covid-19 Last Summer". Forbes. Retrieved 2021-03-19.
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