KRP (biochemistry)
KRP stands for kinesin related proteins. bimC is a subfamily of KRPs and its function is to separate the duplicated centrosomes during mitosis.
Role in mitotic repair
[edit]Kinesin-13 MCAK (Mitotic Centromere-Associated Kinesin) is a KRP that is involved in resolving errors during mitosis involving kinetochore-microtubules. This process is associated with Aurora B Protein Kinase. When Aurora B's function is disrupted, MCAK ability to locate centromeres, which play a critical role in separation of chromosomes during mitosis, was suppressed.[1] There are other environments in which MCAK's function is impaired, absent impact on its associated kinase. For example, alpha-tubulin detyrosination has been demonstrated to impact MCAK's mitotic repair capabilities, suggesting a potential cause of chromosomal instability. [2]
References
[edit]- ^ Andrews PD, Ovechkina Y, Morrice N, Wagenbach M, Duncan K, Wordeman L, Swedlow JR (February 2004). "Aurora B regulates MCAK at the mitotic centromere". Developmental Cell. 6 (2): 253–68. doi:10.1016/s1534-5807(04)00025-5. PMID 14960279.
- ^ Ferreira LT, Orr B, Rajendraprasad G, Pereira AJ, Lemos C, Lima JT, et al. (April 2020). "α-Tubulin detyrosination impairs mitotic error correction by suppressing MCAK centromeric activity". The Journal of Cell Biology. 219 (4). doi:10.1083/jcb.201910064. PMC 7147099. PMID 32328631.
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