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KATNA1

From Wikipedia, the free encyclopedia
KATNA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKATNA1, katanin catalytic subunit A1
External IDsOMIM: 606696; MGI: 1344353; HomoloGene: 56014; GeneCards: KATNA1; OMA:KATNA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204076
NM_007044

NM_011835

RefSeq (protein)

NP_001191005
NP_008975

n/a

Location (UCSC)Chr 6: 149.59 – 149.65 MbChr 10: 7.6 – 7.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Katanin p60 ATPase-containing subunit A1 is an enzyme that in humans is encoded by the KATNA1 gene.[5][6]

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186625Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019794Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McNally FJ, Thomas S (Jan 1999). "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs". Mol Biol Cell. 9 (7): 1847–61. doi:10.1091/mbc.9.7.1847. PMC 25426. PMID 9658175.
  6. ^ a b "Entrez Gene: KATNA1 katanin p60 (ATPase-containing) subunit A 1".

Further reading

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