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Jeffrey Bluestone

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Jeffrey A. Bluestone
Born1953
NationalityAmerican
Alma materRutgers State University, Cornell Graduate School of Medical Science
Known forT cell activation and immune tolerance in autoimmunity, organ transplantation, and cancer[verification needed]
Scientific career
FieldsImmunology
InstitutionsUniversity of California, San Francisco
Doctoral advisorCarlos Lopez
Other academic advisorsDavid Sachs[not verified in body]
Websitebluestonelab.ucsf.edu

Jeffrey A. Bluestone (born in 1953) is an American researcher who is the A.W. and Mary Margaret Clausen Distinguished Professor Emeritus of Metabolism and Endocrinology at the University of California, San Francisco,[1] and was previously executive vice chancellor and provost of that university.[2] He began the UCSF affiliation in 2000, after earlier positions at the NCI-NIH, and at The University of Chicago.[1][third-party source needed]

His research is focused on understanding T cell activation and immune tolerance in autoimmunity and organ transplantation. In April 2016, he co-founded and served as the president and CEO of the Parker Institute for Cancer Immunotherapy,.[3] In 2019, he co-founded and is Chief Executive Officer and President of Sonoma Biotherapeutics.[4]

Early life and education

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Jeffrey A. Bluestone was born in 1953 in Ft. Sill, OK. Bluestone earned his undergraduate and masters degrees in microbiology from Rutgers State University, and his doctoral degree in immunology from Cornell Graduate School of Medical Science.[1][third-party source needed]

Career

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Bluestone started his career in a series of positions at the National Cancer Institute, a part of the National Institutes of Health, where he rose over a period of 7 years to become a senior investigator in the NCI's Immunology Branch.[1][third-party source needed] He then took a position at The University of Chicago as a member of the Ben May Institute for Cancer Research, and as an associate professor (in pathology[citation needed]).[1][third-party source needed] Over 13 years—from 1987 to 2000[citation needed]—he rose to become chairman of the University's Committee on Immunology,[citation needed] and director of that institute,[1] a role he served in from 1995 to 2000.[citation needed]

In 2000, he moved to the University of California, San Francisco,[1] to direct the UCSF Diabetes Center and metabolic research unit.[citation needed] Beginning at least 2011, Bluestone headed the Immune Tolerance Network,[needs update][2][5][third-party source needed] a consortium of over 1000 scientists to focus efforts on the development of immune tolerance therapies,[citation needed] a position that as of January 2022 he listed as a previous one at his UCSF profile.[1] At one time, he was in leadership at the Brehm Coalition;[clarification needed][when?][5] as of January 2022 he was listed as an emeritus member there.[6]

Bluestone became UCSF's interim vice chancellor of research in 2008.[1] In 2009, the efforts of a UCSF committee led by Bluestone made that university a leading institutional recipient of science-directed funds available to universities from the American Recovery and Reinvestment Act.[1][third-party source needed] He became executive vice chancellor and provost of UCSF in 2010,[1][2] a position he held until 2015.[citation needed] As provost, as of 2011 he had set up collaborations with Pfizer, Sanofi-Aventis, and Bayer,[2][needs update] as well as many other UCSF-industry collaborations.[citation needed]

As of January 2022, Bluestone is the A.W. and Mary Margaret Clausen Distinguished Professor of Metabolism and Endocrinology, and the director of the Hormone Research Institute in the Diabetes Center at UCSF.[1] (He is a previous director of the Diabetes Center,[when?] per se.[1]) As of April 2016, he was serving as the president and CEO of the Parker Institute for Cancer Immunotherapy.[3]

Since this date,[when?] Bluestone has been a member of the editorial board for Immunity.[citation needed]

Research

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As of January 2022, Bluestone's research group focuses on studying the role of T cell receptors on regulatory T cells ("Tregs").[citation needed] In the early 90s, he identified the role of CD28 and its interaction with CTLA-4[7][non-primary source needed] The development of soluble receptors of CTLA-4 led to the development of the drugs abatacept and later belatacept.[8][non-primary source needed] Further work with James P. Allison to target CTLA-4 resulted in the development of immune checkpoint therapies also known as immunotherapy.[citation needed] This led to the clinical development of ipilimumab (Yervoy™), which was approved in 2011 by the FDA for the treatment of metastatic melanoma.[citation needed] Their current work on understanding Tregs has been discussed as an avenue to further developments in the treatment Type 1 Diabetes.[9]

Awards and recognition

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Bluestone was elected as a fellow to the American Academy of Arts and Sciences in 2006,[1][third-party source needed] and as a member of the National Academy of Medicine.[when?][citation needed]. In 2023, he was elected to the National Academy of Sciences.

He has received the Mary Tyler Moore and Robert Levine Excellence in Clinical Research Award from the Juvenile Diabetes Research Foundation,[when?] and an award for distinguished alumni from his doctoral institution.[when?][1][third-party source needed]

References

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  1. ^ a b c d e f g h i j k l m n o Bluestone, Jeffrey (January 26, 2022). "Jeffrey Bluestone, PhD". Profiles.UCSF.edu. Retrieved January 26, 2022.
  2. ^ a b c d Timmerman, Luke & Bluestone, Jeff (10 March 2011). "Q&A: UCSF's Jeff Bluestone on the Tricky Balancing Act Between Academia and Industry" (2100-word interview, 300-word introductory biosketch). Xconomy.com. Boston, Mass.: Xconomy, Inc. Retrieved 26 January 2022.{{cite news}}: CS1 maint: multiple names: authors list (link)
  3. ^ a b Farley, Pete (12 April 2016). "UCSF Immunologist to Head New Parker Institute for Cancer Immunotherapy". UC San Francisco. UCSF News. Retrieved 4 August 2016.
  4. ^ Fidler, Ben. "'Treg' cell therapy: bringing CAR-Treg to autoimmune disease". Biopharma Drive. Retrieved 31 August 2022.
  5. ^ a b Brehm Coalition Staff & Bluestone, Jeffrey (4 August 2016). "About Us / Leadership / Jeffrey Bluestone". BrehmCoalition.org. Archived from the original on 2016-08-16. Retrieved 26 January 2022. Jeffrey Bluestone, M.S., Ph.D., is the Director of the University of California, San Francisco Diabetes Center and the Immune Tolerance Network and is AW and Mary Clausen Distinguished Professor of Medicine, Pathology, Microbiology and Immunology. [He] received his undergraduate degree in biology from Rutgers University and a doctorate in immunology from Cornell University. From there he held positions at the National Institute of Health (NIH) and served as the Director of the Ben May Institute for Cancer Research.[third-party source needed]
  6. ^ Brehm Coalition Staff (26 January 2022). "About / Emeritus Members / Jeffrey Bluestone". BrehmCoalition.org. Retrieved 26 January 2022.
  7. ^ Walunas, TL; Lenschow, DJ; Bakker, CY; Linsley, PS; Freeman, GJ; Green, JM; Thompson, CB; Bluestone, JA (August 1994). "CTLA-4 can function as a negative regulator of T cell activation". Immunity. 1 (5): 405–13. doi:10.1016/1074-7613(94)90071-x. PMID 7882171.
  8. ^ Levisetti, MG; Padrid, PA; Szot, GL; Mittal, N; Meehan, SM; Wardrip, CL; Gray, GS; Bruce, DS; Thistlethwaite JR, Jr; Bluestone, JA (1 December 1997). "Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation". Journal of Immunology. 159 (11): 5187–91. doi:10.4049/jimmunol.159.11.5187. PMID 9548454. S2CID 11604489.
  9. ^ Conovo, Susan (26 June 2002). "Stopping Diabetes". www.cumc.columbia.edu. No. 11. In Vivo. Archived from the original on 25 January 2017. Retrieved 4 August 2016.
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