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Jane Osbourn

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Jane Osbourn
OBE
Born
Jane Katharine Osbourn

Bingley, West Yorkshire, England
CitizenshipUnited Kingdom
EducationBingley Grammar School
Queens' College, Cambridge (BSc)
John Innes Centre, Norwich (PhD)
Known forAntibody engineering
Cambridge Antibody Technology
MedImmune
AstraZeneca
STEM
Scientific career
FieldsBiotechnology
ThesisEvidence that nucleocapsid disassembly and a later step in virus replication are inhibited in transgenic tobacco protoplasts expressing TMV coat protein (1991)
Doctoral advisorT. Michael A. Wilson

Jane Osbourn, OBE, is a scientist and former chair of the UK BioIndustry Association.[1]

A Natural Sciences graduate of Queens' College, Cambridge, Osbourn completed several post-graduate qualifications before moving into industry at Cambridge Antibody Technology, that became MedImmune and AstraZeneca.

In the Queen's Birthday Honours list of 2019, Osbourn was awarded the Order of the British Empire medal for services to "Human Monoclonal Antibody Drug Research and Development and Biotechnology".[2]

Early life

[edit]

Osbourn was born in Bingley, West Yorkshire, and attended Bingley Grammar School. She is married to John Richer, Professor of Physics at the Cavendish Laboratory, Cambridge.[3]

She is the sister of Professor Anne Osbourn FRS[4] who investigates plant natural product biosynthesis.

Academic career

[edit]

Osbourn went on to study at the Queens' College, Cambridge, where she obtained a 1st class degree in Natural Sciences (Biochemistry). She was recognised in 1986 for playing netball at Queens,[5] and was awarded both a third year Foundation Scholarship and The Henry Mosseri prize.[6]

She went on to complete a PhD degree at the John Innes Centre for Plant Science Research in Norwich, which resulted in the publication of Evidence that nucleocapsid disassembly and a later step in virus replication are inhibited in transgenic tobacco protoplasts expressing TMV coat protein.[7] Following this, she completed a post-doctoral position at Rutgers University, New Jersey, United States, undertaking research directed towards clarification of the sequence elements responsible for the translational enhancement effect conferred by the 5' untranslated region of Tobacco Mosaic Virus known as omega.[8]

Osbourn then moved into medical research through a British Heart Foundation Post-Doctoral Fellowship at the Department of Medicine at Addenbrooke's Hospital in Cambridge.[9]

Career in industry

[edit]

In 1993 she moved to a small, Cambridge-based, start-up biotechnology company called Cambridge Antibody Technology.[10] CAT, as it was called, would pioneer the use of Phage Display technology that ultimately discovered important drugs such as Humira.[11]

She was the key author of several scientific papers, including Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library, Nature Biotechnology, 1996[12] and Human Antibodies by Design, Nature Biotechnology, 1998.[13] She is co-author of several others pertaining to antibody discovery and development:

  • A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy, Cancer Cell, 2019 [14]
  • Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment, Sci Rep, 2018 [15]
  • A novel in vivo method for isolating antibodies from a phage display library by neuronal retrograde transport selectively yields antibodies against p75(NTR.), MAbs, 2013 [16]
  • Applications of ribosome display to antibody drug discovery, Expert Opin Biol Ther, 2015 [17]
  • Signal amplification in flow cytometry using biotin tyramine, Cytometry, 1999 [18]
  • Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes, J Vasc Res, 1999 [19]
  • Directed selection of MIP-1 alpha neutralizing CCR5 antibodies from a phage display human antibody library, Nat Biotechnology, 1999 [20]
  • Pathfinder selection: in situ isolation of novel antibodies, Immunotechnology, 1998 [21]
  • Generation of a panel of related human scFv antibodies with high affinities for human CEA, Immunotechnology, 1996 [22]

Osbourn is listed as an inventor on several patents, which are (in chronological order):

  • EP0865492B1 - Specific binding members for human carcinoembryonic antigen, materials and methods[23]
  • EP0906571 - Labelling and selection of molecules[24]
  • US5994519A - Labelling and selection of molecules[25]
  • EP1353180B1 - Labelling and selection of molecules[26]
  • US7074557 - Ribosome Display[27]
  • EP1268766 - Improvements to Ribosome Display[28]
  • WO2001075097A2 - Improvements to Ribosome Display[29]

Osbourn also created a technique to assist with the discovery of proximity-guided selection of antibodies, so called Proximol.[30]

CAT was acquired by AstraZeneca in 2006[31] and in the following year was merged with a US-based company called MedImmune [32] to form AstraZeneca’s global biologics R&D arm. During this time Osbourn began to speak about opportunities for diversity in science.[33]

In 2013, AstraZeneca announced its decision to relocate its headquarters to Cambridge, UK.[34] Jonathan Burroughs, of Creative Places, wrote in 2015 that Osbourn had an influence over this decision.[35]

In February 2019, it was announced that Osbourn would be leaving AstraZeneca.[36] Since November 2019, Osbourn has been Chief Scientific Office of antibody therapeutics discovery company Alchemab Therapeutics.

Recognition

[edit]

Her early interest in science has grown into a passion for science education, supporting and championing life science education programmes and she is established as an advisor and mentor to many young researchers in the life science sector. She has been acknowledged by a number of different pharmaceutical media groups for these qualities.[citation needed]

  • She has been recognised in two BioBeat Movers and Shakers lists - BioBeat 50 Movers and Shakers in BioBusiness 2014 and 2016.[37][38] BioBeat is an organisation that connects entrepreneurs with the leaders in biotech.[39]
  • In 2016 she was recognised in the PharmaVoice 100 researchers and scientists.[40] PharmaVOICE is a resource for life-sciences executives and other healthcare-service related professionals[41]
  • In 2016, Fierce Pharma’s “Fierce Women in Biopharma” recognised her as one of 15 women in the global industry noteworthy for their leadership, providing mentorship and helping increase opportunities for women in science.[42] FierceBiotech and its family of publications provide end-to-end coverage of biotech and medtech, from pre-clinical science through clinical testing and regulatory approval.[43]

In 2014 Osbourn was elected to join the board of the BioIndustry Association, becoming Chair in 2016;[1] and in this role she has been working to support the development of the biotechnology sector in the UK. She also does this through her roles as a Director of Babraham Bioscience Technologies[44] and as a Director of Cambridge Enterprise, the technology transfer organisation for University of Cambridge.[45]

Osbourn has presented at a number of parliamentary Select Committees. At the Business, Innovation and Skills Committee, on Tuesday 13 May 2014, she gave evidence on behalf of AstraZeneca as it faced a potential takeover from Pfizer.[46][47]

On 1 July that year, Osbourn gave evidence to the Science and Technology Select Committee: Priorities for Scientific Research.[48]

Osbourn has also has previously served as a Member of the UK Medical Research Council Industry Grant Award Assessment Panel.[49]

In 2018 the Nobel Prize for Chemistry was awarded jointly to Sir Greg Winter, George Smith and Frances Arnold. Winter received his award for the phage display of peptides and antibodies.[50] Sir Greg and David Chiswell had founded Cambridge Antibody Technology to exploit this science. Osbourn says of this time, "There was a cohort of really able intellect in Cambridge – in CAT and other companies, in the MRC LMB and in the University – and what happened was a condensation of that focus… Once we decided to make phage display work, we set some really tough goals and then just got on with it."[51] To recognise Jane’s contribution to the prize, she, along with David Chiswell and John McCafferty, accompanied Sir Greg to the Nobel ceremony.[51]

On 7 June 2019 she was awarded an OBE for services to Human Monoclonal Antibody Drug Research and Development and Biotechnology.[2] CEO of AstraZeneca, Pascal Soriot, said of the award "On behalf of AstraZeneca, I am delighted to congratulate Dr Jane Osbourn for her award of an OBE in recognition of her services to human monoclonal antibody drug research and development and biotechnology. This well-deserved honour reflects her contribution to biopharmaceutical science over more than 25 years, from Cambridge Antibody Technology to AstraZeneca and MedImmune. Jane’s leadership in UK life sciences includes championing the biotech sector through her position as chair of the BIA and contributing to the growth of the UK’s scientific ecosystem. I would also like to recognise her authentic commitment to building skills through STEM and education outreach, in particular for women in science".[52][53]

References

[edit]
  1. ^ a b "MedImmune's Jane Osbourn announced as new BIA chair alongside new board appointments". Bioindustry.org.
  2. ^ a b "The Queen's Birthday Honours List 2019". Gov.uk.
  3. ^ "Professor John S Richer". 19 April 2013.
  4. ^ Osbourn, Anne (30 July 2015). "Anne Osbourn". New Phytologist. 208 (1): 23–25. doi:10.1111/nph.13616. PMID 26311283.
  5. ^ "Queens' College Record 1986" (PDF). Queens.cam.ac.uk. Retrieved 1 August 2019.
  6. ^ "The Record 1988". Issuu.com. Retrieved 1 August 2019.
  7. ^ Osbourn, J. K.; Watts, J. W.; Beachy, R. N.; Wilson, T. M. (30 September 1989). "Evidence that nucleocapsid disassembly and a later step in virus replication are inhibited in transgenic tobacco protoplasts expressing TMV coat protein". Virology. 172 (1): 370–373. doi:10.1016/0042-6822(89)90143-8. PMID 2773325.
  8. ^ "Complementation of coat protein-defective TMV mutants in transgenic tobacco plants expressing TMV coat protein | Jane K. Osbourn | Request PDF". ResearchGate.
  9. ^ "Dr Jane Osbourn of AstraZeneca and UK BioIndustry Affiliation thanks colleagues as she is made an OBE". danilposh. 7 June 2019.
  10. ^ "Jane joined what was Cambridge Antibody Technology (CAT)/MedImmune, in 1993". www.cambridgeindependent.co.uk. 7 June 2019.
  11. ^ "The Top 15 Best-Selling Drugs of 2016". Genengnews.com. 6 March 2017.
  12. ^ Vaughan, Tristan J.; Williams, Andrew J.; Pritchard, Kevin; Osbourn, Jane K.; Pope, Anthony R.; Earnshaw, John C.; McCafferty, John; Hodits, Regina A.; Wilton, Jane; Johnson, Kevin S. (31 March 1996). "Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library". Nature Biotechnology. 14 (3): 309–314. doi:10.1038/nbt0396-309. PMID 9630891. S2CID 23088502.
  13. ^ Vaughan, T. J.; Osbourn, J. K.; Tempest, P. R. (30 June 1998). "Human antibodies by design". Nature Biotechnology. 16 (6): 535–539. doi:10.1038/nbt0698-535. PMID 9624683. S2CID 26878742.
  14. ^ Li, JY (10 June 2019). "A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy". Cancer Cell. 35 (6): 948–949. doi:10.1016/j.ccell.2019.05.010. PMID 31185215.
  15. ^ Chodorge, M (3 December 2018). "Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment". Sci Rep. 8 (1): 17545. Bibcode:2018NatSR...817545C. doi:10.1038/s41598-018-35869-4. PMC 6277417. PMID 30510163.
  16. ^ Tani, H (May 2013). "A novel in vivo method for isolating antibodies from a phage display library by neuronal retrograde transport selectively yields antibodies against p75(NTR.)". mAbs. 5 (3): 471–478. doi:10.4161/mabs.24112. PMC 4169038. PMID 23549155.
  17. ^ Groves, MA (2015). "Applications of ribosome display to antibody drug discovery". Expert Opin Biol Ther. 5 (1): 125–135. doi:10.1517/14712598.5.1.125. PMID 15709915. S2CID 23837532.
  18. ^ Earnshaw, JC (1999). "Signal amplification in flow cytometry using biotin tyramine". Cytometry. 35 (2): 176–9. doi:10.1002/(SICI)1097-0320(19990201)35:2<176::AID-CYTO10>3.0.CO;2-S. PMID 10554174.
  19. ^ Shanahan, CM (1999). "Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes". J Vasc Res. 36 (5): 353–362. doi:10.1159/000025674. PMID 10559675. S2CID 38978988.
  20. ^ Osbourn, JK (1989). "Directed selection of MIP-1 alpha neutralizing CCR5 antibodies from a phage display human antibody library". Nat Biotechnol. 16 (8): 778–781. doi:10.1038/nbt0898-778. PMID 9702779. S2CID 23773974.
  21. ^ Osbourn, JK (1998). "Pathfinder selection: in situ isolation of novel antibodies". Immunotechnology. 3 (4): 293–302. doi:10.1016/S1380-2933(97)10007-0. PMID 9530562.
  22. ^ Osbourn, JK (1996). "Generation of a panel of related human scFv antibodies with high affinities for human CEA". Immunotechnology. 2 (3): 181–96. doi:10.1016/S1380-2933(96)00046-2. PMID 9373311.
  23. ^ "Specific binding members for human carcinoembryonic antigen, materials and methods". Patents.google.com. Retrieved 1 August 2019.
  24. ^ "Labelling and selection of molecules". Patents.google.com. Retrieved 1 August 2019.
  25. ^ "Labelling and selection of molecules". Patents.google.com. Retrieved 1 August 2019.
  26. ^ "Labelling and selection of molecules". Patents.google.com. Retrieved 1 August 2019.
  27. ^ "Ribosome display". Patents.google.com. Retrieved 1 August 2019.
  28. ^ "About this file - European Patent Register". Register.epo.org.
  29. ^ "Improvements to ribosome display". Patents.google.com. Retrieved 1 August 2019.
  30. ^ Osbourn, Jane K. (30 July 2002). "Proximity-guided (ProxiMol) antibody selection". Antibody Phage Display. Methods in Molecular Biology. Vol. 178. pp. 201–205. doi:10.1385/1-59259-240-6:201. ISBN 1-59259-240-6. PMID 11968489.
  31. ^ "AstraZeneca to buy CAT for £702m". News.bbc.co.uk. 15 May 2006.
  32. ^ "AstraZeneca International - pharmaceutical company, prescription drugs, medicine manufacturers". 13 January 2010. Archived from the original on 13 January 2010.
  33. ^ "How can we encourage more girls to study science?". The Independent. 9 December 2014.
  34. ^ "Cambridge HQ for pharmaceutical firm". Bbc.co.uk. 18 June 2013.
  35. ^ "Creative Places | Open Innovation". Creativeplaces.com.
  36. ^ "BIA chairwomen Jane Osbourn to leave AstraZeneca". Thepharmaletter.com.
  37. ^ "50 Movers and Shakers in BioBusiness 2014" (PDF). Mws-consulting.co.uk. Retrieved 1 August 2019.
  38. ^ "50 Movers and Shakers in BioBusiness 2016" (PDF). Mws-consulting.co.uk. Retrieved 1 August 2019.
  39. ^ "Biobeat 2018". Mws-consulting.co.uk. Retrieved 1 August 2019.
  40. ^ "The Researchers & Scientists". Pharmavoice.com. Retrieved 1 August 2019.
  41. ^ "About Us". Pharmavoice.com. Retrieved 1 August 2019.
  42. ^ "Fierce Women in Biopharma 2016". FiercePharma.com. Retrieved 1 August 2019.
  43. ^ "About Us". FiercePharma.com. Retrieved 1 August 2019.
  44. ^ "BABRAHAM BIOSCIENCE TECHNOLOGIES LIMITED - Officers (free information from Companies House)". Beta.companieshouse.gov.uk.
  45. ^ "CAMBRIDGE ENTERPRISE LIMITED - Filing history (free information from Companies House)". Beta.companieshouse.gov.uk.
  46. ^ "Parliamentlive.tv". Parliamentlive.tv.
  47. ^ "[Committee name]". Data.parliament.uk.
  48. ^ "SCIENCE AND TECHNOLOGY SELECT COMMITTEE : 2025: Priorities for Scientific Research : Oral and written evidence" (PDF). Parliament.uk. Retrieved 1 August 2019.
  49. ^ "AZ and MedImmune to spearhead biotech judging | Business Weekly | Technology News | Business news | Cambridge and the East of England". Businessweekly.co.uk.
  50. ^ "The Nobel Prize in Chemistry 2018". NobelPrize.org.
  51. ^ a b Walsh, Louise (20 March 2019). "A very Cambridge story". University of Cambridge.
  52. ^ "World leading antibody scientist Dr Jane Osbourn awarded OBE in Queen's Honours". bioindustry.org.
  53. ^ "Dr Jane Osbourn of AstraZeneca and UK BioIndustry Association thanks colleagues as she is made an OBE". www.cambridgeindependent.co.uk. 7 June 2019.
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