Itsik Pe'er
Itsik Pe'er | |
|---|---|
| Alma mater | Tel Aviv University |
| Scientific career | |
| Fields | Systems biology Human Genetics Computer Science |
| Institutions | Columbia University Broad Institute Weizmann Institute of Science |
| Thesis | Algorithmic Methods for Reconstruction of Biological Sequences, Gene Orders and Maps (2002) |
| Doctoral advisor | Ron Shamir |
Itsik Pe'er is a computational biologist and a Full Professor in the Department of Computer Science at Columbia University.
Research and career
[edit]Pe'er has created computational tools for the analysis of high-throughput DNA sequence data.[1] In particular, he has developed an approach to map copy number variation from whole exome sequencing data. He has published approaches to quantify hidden relatedness and infer population structure using DNA data.[2] He has conducted studies on the genetics of complex traits in Ashkenazi Jews, historically a relatively isolated population[3] enabling identification of genetic risk factors for common disorders in all populations.[4][5] He is generating a comprehensive resource of genetic variants in the population for precision public health.[6][7]
Selected publications
[edit]- Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. I Pe'er, R Yelensky, D Altshuler, MJ Daly Genetic Epidemiology. 32(4):381-5. doi:10.1002/gepi.20303
- Evaluating and improving power in whole-genome association studies using fixed marker sets. I Pe'er, PIW de Bakker, J Maller, R Yelensky, D Altshuler, MJ Daly Nature Genetics. 38(6):663-667. doi:10.1038/ng1816
- Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins. Shai Carmi, Ken Y Hui, Ethan Kochav, Xinmin Liu, James Xue, Fillan Grady, Saurav Guha, Kinnari Upadhyay, Dan Ben-Avraham, Semanti Mukherjee, B Monica Bowen, Tinu Thomas, Joseph Vijai, Marc Cruts, Guy Froyen, Diether Lambrechts, Stéphane Plaisance, Christine Van Broeckhoven, Philip Van Damme, Herwig Van Marck, Nir Barzilai, Ariel Darvasi, Kenneth Offit, Susan Bressman, Laurie J Ozelius, Inga Peter, Judy H Cho, Harry Ostrer, Gil Atzmon, Lorraine N Clark, Todd Lencz, Itsik Pe’er. Nature Communications. doi:10.1038/ncomms5835
Personal life
[edit]Itsik Pe'er is married to Dana Pe'er, a computational biologist at Sloan Kettering Institute.[8]
References
[edit]- ^ "Itsik Pe'er publications indexed by Google Scholar". scholar.google.com. Retrieved 2022-01-02.
- ^ "Inference of population structure from time-series genotype data". Banff International Research Station. Retrieved 2022-01-04.
- ^ Bray SM, Mulle JG, Dodd AF, Pulver AE, Wooding S, Warren ST (September 2010). "Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population". Proceedings of the National Academy of Sciences. 107 (37): 16222–16227. Bibcode:2010PNAS..10716222B. doi:10.1073/pnas.1004381107. PMC 2941333. PMID 20798349.
- ^ "Itsik Pe'er - Overview". Columbia University. Retrieved 2022-01-03.
- ^ Lencz T, Yu J, Palmer C, Carmi S, Ben-Avraham D, Barzilai N, Peer I (April 2018). "High-depth whole genome sequencing of an Ashkenazi Jewish reference panel: enhancing sensitivity, accuracy, and imputation". Human Genetics. 137 (4): 343–355. doi:10.1007/s00439-018-1886-z. PMC 6954822. PMID 29705978.
- ^ "Mapping the DNA sequence of Ashkenazi Jews". The Jerusalem Post. 28 September 2014. Retrieved 2022-01-03.
- ^ "April 10 Provost's Lecture with Itsik Pe'er". Stony Brook University News. 27 March 2014. Retrieved 2022-01-03.
- ^ "Columbia News - Dana Pe'er: Decoding Genetic Variations and Regulatory Networks" (PDF). www.columbia.edu. Retrieved 2022-01-04.