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Protein-coding gene in the species Homo sapiens
InaD-like protein is a protein that in humans is encoded by the PATJ gene .[ 5] [ 6] [ 7]
This gene encodes a protein with multiple PDZ domains . PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.[ 7]
INADL has been shown to interact with MPP5 .[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000132849 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061859 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Philipp S, Flockerzi V (Sep 1997). "Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster" . FEBS Lett . 413 (2): 243–8. doi :10.1016/S0014-5793(97)00877-6 PMID 9280290 . ^ Soejima H, Kawamoto S, Akai J, Miyoshi O, Arai Y, Morohka T, Matsuo S, Niikawa N, Kimura A, Okubo K, Mukai T (May 2001). "Isolation of novel heart-specific genes using the BodyMap database". Genomics . 74 (1): 115–20. doi :10.1006/geno.2001.6527 . PMID 11374908 . ^ a b "Entrez Gene: INADL InaD-like (Drosophila)" .^ Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (Apr 2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost" . J. Cell Biol . 157 (1): 161–72. doi :10.1083/jcb.200109010 . PMC 2173254 PMID 11927608 .
Fanning AS, Anderson JM (1999). "PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane" . J. Clin. Invest . 103 (6): 767–72. doi :10.1172/JCI6509 . PMC 408156 PMID 10079096 . Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression" . Genomics . 33 (1): 151–2. doi :10.1006/geno.1996.0177 PMID 8617505 . Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci . 11 (3): 161–72. doi :10.1006/mcne.1998.0679 . PMID 9647694 . S2CID 36534759 . Vaccaro P, Brannetti B, Montecchi-Palazzi L, Philipp S, Helmer Citterich M, Cesareni G, Dente L (2001). "Distinct binding specificity of the multiple PDZ domains of INADL, a human protein with homology to INAD from Drosophila melanogaster" . J. Biol. Chem . 276 (45): 42122–30. doi :10.1074/jbc.M104208200 PMID 11509564 . Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E (2002). "The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons" . J. Biol. Chem . 277 (19): 16655–61. doi :10.1074/jbc.M201087200 PMID 11872753 . Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost" . J. Cell Biol . 157 (1): 161–72. doi :10.1083/jcb.200109010 . PMC 2173254 PMID 11927608 . Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A (2002). "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells" . J. Biol. Chem . 277 (28): 25408–15. doi :10.1074/jbc.M202196200 PMID 11964389 . Roh MH, Liu CJ, Laurinec S, Margolis B (2002). "The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions" . J. Biol. Chem . 277 (30): 27501–9. doi :10.1074/jbc.M201177200 PMID 12021270 . Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B (2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)". Gene . 302 (1–2): 21–9. doi :10.1016/S0378111902010843 . PMID 12527193 . Roh MH, Fan S, Liu CJ, Margolis B (2004). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells". J. Cell Sci . 116 (Pt 14): 2895–906. doi :10.1242/jcs.00500 . PMID 12771187 . S2CID 4482921 . Li Y, Karnak D, Demeler B, Margolis B, Lavie A (2005). "Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes" . EMBO J . 23 (14): 2723–33. doi :10.1038/sj.emboj.7600294 . PMC 514954 PMID 15241471 . Michel D, Arsanto JP, Massey-Harroche D, Béclin C, Wijnholds J, Le Bivic A (2005). "PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells". J. Cell Sci . 118 (Pt 17): 4049–57. doi :10.1242/jcs.02528 . PMID 16129888 . S2CID 19826254 . Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G (2007). "Uncovering Quantitative Protein Interaction Networks for Mouse PDZ Domains using Protein Microarrays" . J. Am. Chem. Soc . 128 (17): 5913–22. doi :10.1021/ja060943h . PMC 2533859 PMID 16637659 . Wells CD, Fawcett JP, Traweger A, Yamanaka Y, Goudreault M, Elder K, Kulkarni S, Gish G, Virag C, Lim C, Colwill K, Starostine A, Metalnikov P, Pawson T (2006). "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells" . Cell . 125 (3): 535–48. doi :10.1016/j.cell.2006.02.045 PMID 16678097 . S2CID 18651810 .
PDB gallery
2d92 : Solution structure of the fifth PDZ domain of InaD-like protein
2daz : Solution structure of the 7th PDZ domain of InaD-like protein
2db5 : Solution structure of the first PDZ domain of InaD-like protein
2dlu : Solution structure of the second PDZ domain of human InaD-like protein
2dm8 : Solution structure of the eighth PDZ domain of human InaD-like protein
2dmz : Solution structure of the third PDZ domain of human InaD-like protein
