Ilepcimide

Ilepcimide
Clinical data
ATC code	none;
Identifiers
	IUPAC name (2E)-3-(2H-1,3-Benzodioxol-5-yl)-1-(piperidin-1-yl)prop-2-en-1-one;
CAS Number	82857-82-7 ;
PubChem CID	641115;
ChemSpider	556435 ;
UNII	5ML58O200F;
Chemical and physical data
Formula	C15H17NO3
Molar mass	259.305 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CCN(CC1)C(=O)/C=C/C2=CC3=C(C=C2)OCO3;
	InChI InChI=1S/C15H17NO3/c17-15(16-8-2-1-3-9-16)7-5-12-4-6-13-14(10-12)19-11-18-13/h4-7,10H,1-3,8-9,11H2/b7-5+ ; Key:BLPUOQGPBJPXRL-FNORWQNLSA-N ;
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Ilepcimide, also known as antiepilepserine, is an anticonvulsant.^[1] It is a piperidine derivative that was first synthesized by Chinese researchers as an analogue of piperine, the main pungent compound and phytochemical of black pepper (and of other plants in the family Piperaceae).

Ilepcimide has serotonergic activity.^[1]^[2]^[3]

References

^ ^a ^b Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. p. 1116. ISBN 978-0-412-46630-4. Retrieved 30 November 2012.
^ Liu GQ, Algeri S, Ceci A, Garattini S, Gobbi M, Murai S (December 1984). "Stimulation of serotonin synthesis in rat brain after antiepilepsirine, an antiepileptic piperine derivative". Biochemical Pharmacology. 33 (23): 3883–6. doi:10.1016/0006-2952(84)90055-8. PMID 6210090.
^ Yan QS, Mishra PK, Burger RL, Bettendorf AF, Jobe PC, Dailey JW (May 1992). "Evidence that carbamazepine and antiepilepsirine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats". The Journal of Pharmacology and Experimental Therapeutics. 261 (2): 652–9. PMID 1374472.

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