From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene .[ 5] [ 6] [ 7]
IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.[ 7]
IRS4 has been shown to interact with CRK [ 8] [ 9] NISCH .[ 10]
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