Hydroxymethylglutaryl-CoA reductase (NADPH)
| hydroxymethylglutaryl-CoA reductase (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 HMG-CoA reductase tetramer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 1.1.1.34 | ||||||||
| CAS no. | 9028-35-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) is an enzyme that catalyzes the chemical reaction
- (R)-mevalonate + CoA + 2 NADP+ (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NADP+, whereas its 3 products are (S)-3-hydroxy-3-methylglutaryl-CoA, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in biosynthesis of steroids including cholesterol. The statin class of anticholesterol drugs act through inhibiting this enzyme.
Nomenclature
[edit]The systematic name of this enzyme class is (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating). Other names in common use include:
- hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate)
- 3-hydroxy-3-methylglutaryl-CoA reductase
- β-hydroxy-β-methylglutaryl coenzyme A reductase
- hydroxymethylglutaryl CoA reductase (NADPH)
- S-3-hydroxy-3-methylglutaryl-CoA reductase
- NADPH-hydroxymethylglutaryl-CoA reductase
- HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA)
- 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
- hydroxymethylglutaryl-CoA reductase (NADPH2).
Structural studies
[edit]As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1DQ8, 1DQ9, 1DQA, 1HW8, 1HW9, 1HWI, 1HWJ, 1HWK, 1HWL, 2Q1L, 2Q6B, and 2Q6C.
References
[edit]- Bucher NL, Overath P, Lynen F (1960). "β-Hydroxy-β-methylglutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver". Biochim. Biophys. Acta. 40: 491–501. doi:10.1016/0006-3002(60)91390-1. PMID 13805544.
- Durr IF, Rudney H (1960). "The reduction of β-hydroxy-β-methyl-glutaryl coenzyme A to mevalonic acid". J. Biol. Chem. 235 (9): 2572–8. doi:10.1016/S0021-9258(19)76915-4. PMID 13818862.
- Kawachi T, Rudney H (1970). "Solubilization and purification of β-hydroxy-β-methylglutaryl coenzyme A reductase from rat liver". Biochemistry. 9 (8): 1700–5. doi:10.1021/bi00810a008. PMID 4985697.
