Hops and cannabinoids
Research has shown that Humulus lupulus (the plant that makes hops) and Cannabis sativa (also called hemp and marijuana) are closely related,[1][a] and it may be possible to create novel cultivars of hops that express valuable chemicals similar to commercial hemp. Both hops and cannabis contain terpenes and terpenoids; tetrahydrocannabinol (THC) is a terpenoid.[3][4] Hops lack the enzyme that could convert cannabigerolic acid into THC or CBD,[5] but it could be inserted using genetic engineering as was done in 2019 for yeast.[6][7]
Notes
[edit]See also
[edit]References
[edit]- ^ Briggs et al. 2004, p. 228.
- ^ Small 2016.
- ^ Andre, Christelle M.; Hausman, Jean-Francois; Guerriero, Gea (2016), "Cannabis sativa: The Plant of the Thousand and One Molecules", Frontiers in Plant Science, 7 (19): 19, doi:10.3389/fpls.2016.00019, PMC 4740396, PMID 26870049
- ^ Harbison, Martha (November 15, 2012), "BeerSci: What's The Connection Between Hops And Marijuana? Because they sure look and smell alike.", Popular Science
- ^ Kaplan, Josh (July 12, 2018). "Does CBD Only Come From Cannabis and Hemp?". Leafly.
- ^ Bushwick, Sophie (February 27, 2019). "Rising High: GM Yeast Generates Known and Novel Marijuana Compounds – Engineered microorganisms churn out THC, CBD and rarer, less-understood cannabis cousins". Scientific American.
- ^ Luo, Xiaozhou; Reiter, Michael A.; d’Espaux, Leo; Wong, Jeff; Denby, Charles M.; Lechner, Anna; Zhang, unfeng; Grzybowski, Adrian T.; Harth, Simon; Lin, Weiyin; Lee, Hyunsu; Yu, Changhua; Shin, John; Deng, Kai; Benites, Veronica T.; Wang, George; Baidoo, Edward E. K.; Chen, Yan; Dev, Ishaan; Petzold, Christopher J.; Keasling, Jay D. (February 27, 2019), "Complete biosynthesis of cannabinoids and their unnatural analogues in yeast" (PDF), Nature, 567 (7746): 123–126, Bibcode:2019Natur.567..123L, doi:10.1038/s41586-019-0978-9, PMID 30814733, S2CID 71147445
Sources
[edit]- Small, Ernest (November 2016). "Prehuman and early history of Cannabis sativa". Cannabis: A Complete Guide. CRC Press. ISBN 978-1498761635. OCLC 971400059.
- Briggs, Dennis E.; Brookes, Peter A.; Stevens, Roger; Boulton, Chris A. (2004). "Hops – Botany". Brewing Science and Practice. Elsevier Science. pp. 228–230. OCLC 469858708.
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