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Histolysain

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Histolysin
Identifiers
EC no.3.4.22.35
CAS no.92228-52-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

Histolysin (EC 3.4.22.35, histolysin, Entamoeba histolytica cysteine proteinase, amebapain, Entamoeba histolytica cysteine protease, Entamoeba histolytica neutral thiol proteinase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg- in small molecule substrates including Z-Arg-Arg-!NHMec

This enzyme is present in the protozoan, Entamoeba histolytica.

References

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  1. ^ Lushbaugh WB, Hofbauer AF, Pittman FE (June 1985). "Entamoeba histolytica: purification of cathepsin B". Experimental Parasitology. 59 (3): 328–36. doi:10.1016/0014-4894(85)90088-8. PMID 2860002.
  2. ^ Luaces AL, Barrett AJ (March 1988). "Affinity purification and biochemical characterization of histolysin, the major cysteine proteinase of Entamoeba histolytica". The Biochemical Journal. 250 (3): 903–9. doi:10.1042/bj2500903. PMC 1148941. PMID 2898937.
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