Histidinol-phosphate transaminase
| histidinol-phosphate transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Histidinol-phosphate transaminase homodimer, E.Coli | |||||||||
| Identifiers | |||||||||
| EC no. | 2.6.1.9 | ||||||||
| CAS no. | 9032-98-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a histidinol-phosphate transaminase (EC 2.6.1.9) is an enzyme that catalyzes the chemical reaction
- L-histidinol phosphate + 2-oxoglutarate 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
Thus, the two substrates of this enzyme are L-histidinol phosphate and 2-oxoglutarate, whereas its two products are 3-(imidazol-4-yl)-2-oxopropyl phosphate and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-histidinol-phosphate:2-oxoglutarate aminotransferase. Other names in common use include imidazolylacetolphosphate transaminase, glutamic-imidazoleacetol phosphate transaminase, histidinol phosphate aminotransferase, imidazoleacetol phosphate transaminase, L-histidinol phosphate aminotransferase, histidine:imidazoleacetol phosphate transaminase, IAP transaminase, and imidazolylacetolphosphate aminotransferase. This enzyme participates in 5 metabolic pathways: histidine metabolism, tyrosine metabolism, phenylalanine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, and novobiocin biosynthesis. It employs one cofactor, pyridoxal phosphate.
Structural studies
[edit]As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 1FG3, 1FG7, 1GEW, 1GEX, 1GEY, 1H1C, 1IJI, 1UU0, 1UU1, 1UU2, and 2F8J.
References
[edit]- AMES BN, HORECKER BL (1956). "The biosynthesis of histidine: imidazoleacetol phosphate transaminase". J. Biol. Chem. 220 (1): 113–28. doi:10.1016/S0021-9258(18)65337-2. PMID 13319331.
- Martin RG; Goldberger RF (1963). "Imidazolylacetolphosphate:L-glutamate aminotransferase. Purification and properties". J. Biol. Chem. 242 (6): 1168–1174. doi:10.1016/S0021-9258(18)96159-4. PMID 5337155.
