Hepsin

Hepsin (EC 3.4.21.106) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys

This type-II membrane-associated serine peptidase plays a role in cell growth and development.

References

^ Zhukov A, Hellman U, Ingelman-Sundberg M (January 1997). "Purification and characterization of hepsin from rat liver microsomes". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1337 (1): 85–95. doi:10.1016/s0167-4838(96)00152-5. PMID 9003440.
^ Kazama Y, Hamamoto T, Foster DC, Kisiel W (January 1995). "Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation". The Journal of Biological Chemistry. 270 (1): 66–72. doi:10.1074/jbc.270.1.66. PMID 7814421.
^ Torres-Rosado A, O'Shea KS, Tsuji A, Chou SH, Kurachi K (August 1993). "Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth". Proceedings of the National Academy of Sciences of the United States of America. 90 (15): 7181–5. Bibcode:1993PNAS...90.7181T. doi:10.1073/pnas.90.15.7181. PMC 47100. PMID 8346233.

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v t e Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic
Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator
Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase
Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin
Venombin	Ancrod Batroxobin
Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin/S1P4 Sedolisin/TPP1 Streptokinase Cathepsin A G

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)