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Helen Donis-Keller

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Helen R. Donis-Keller
Alma materHarvard University
Scientific career
InstitutionsOlin College of Engineering
ThesisEnzymatic RNA sequencing and fractionation methods (1979)

Helen Donis-Keller is the Michael E. Moody Professor and Professor of Biology and Art at Olin College of Engineering in Needham, Massachusetts.

Education and career

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Donis-Keller has a B.Sc. and an H.B.Sc. from Lakehead University. She earned her Ph.D. at Harvard University under the direction of Walter Gilbert in 1979.[1] After employment at the biotechnology companies Biogen and Collaborative Research, she joined the faculty at Washington University School of Medicine.[2][3] In 2001, she earn an MFA in studio art from the School of the Museum of Fine Arts in Boston and Tufts University[citation needed] and she joined the faculty at the Olin College of Engineering.[1] In 2012, she was named the Michael. E. Moody Faculty Chair.[4]

Research

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Donis-Keller's graduate research established a method to do RNA sequencing.[5][6][7] During her time at Collaborative Research, her research group created the first genetic map of the human genome.[8] Donis-Keller was unable to secure either NIH or venture funding for generating the RFLP map, but convinced Collaborative Research's management to fund the project.[9][10] She continued to work on the genetic linkage map[11] and led research into understanding the genetic basis of cystic fibrosis,[12] thyroid cancer,[13] and breast cancer.[14][15]

Selected publications

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  • Donis-Keller, Helen; Maxam, Allan M.; Gilbert, Walter (1977). "Mapping adenines, guanines, and pyrimidines in RNA". Nucleic Acids Research. 4 (8): 2527–2538. doi:10.1093/nar/4.8.2527. ISSN 0305-1048. PMC 342589. PMID 409999.
  • Doniskeller, H (October 1987). "A genetic linkage map of the human genome". Cell. 51 (2): 319–337. doi:10.1016/0092-8674(87)90158-9. ISSN 0092-8674. PMID 3664638. S2CID 7230640.
  • Donis-Keller, Helen; Dou, Shenshen; Chi, David; Carlson, Katrin M.; Toshima, Koji; Lairmore, Terry C.; Howe, James R.; Moley, Jeffrey F.; Goodfellow, Paul; Wells, Samuel A. (1993). "Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC". Human Molecular Genetics. 2 (7): 851–856. doi:10.1093/hmg/2.7.851. ISSN 0964-6906. PMID 8103403.

Awards

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  • Doctor of Science Degree (Honoris Causa) from Lakehead University (1995)[16]

Art

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In addition to teaching art at Olin,[2] Donis-Keller is herself an artist, and her art can be seen at Needham's 2021 Open Studios event[17] and other venues.[18][19][20] Her Ph.D. advisor, Walter Gilbert, has also begun to investigate the intersection between art and science though, in a 2015 interview, Donis-Keller did not recall his interest in art while she was a student in his lab.[21]

References

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  1. ^ a b "Helen Donis-Keller | Art, Science, and Education". Retrieved 2021-09-26.
  2. ^ a b "Faculty Profile for Helen Donis-Keller, Ph.D. | Olin College of Engineering". www.olin.edu. Retrieved 2021-09-26.
  3. ^ "Committee Biographies". Assessing Genetic Risks: Implications for Health and Social Policy: Committee Biographies. National Academies Press (US). 1994.
  4. ^ "Olin College Names Professor Helen Donis-Keller as Inaugural Holder of the Michael E. Moody Chair". PRWeb. December 20, 2012. Archived from the original on 2021-09-27. Retrieved 2021-09-27.
  5. ^ Donis-Keller, Helen; Maxam, Allan M.; Gilbert, Walter (1977). "Mapping adenines, guanines, and pyrimidines in RNA". Nucleic Acids Research. 4 (8): 2527–2538. doi:10.1093/nar/4.8.2527. ISSN 0305-1048. PMC 342589. PMID 409999.
  6. ^ Donis-Keller, Helen (1979). "Site specific enzymatic cleavage of RNA". Nucleic Acids Research. 7 (1): 179–192. doi:10.1093/nar/7.1.179. ISSN 0305-1048. PMC 328004. PMID 386279.
  7. ^ Donis-Keller, Helen (1980). "Phy M: an RNase activity specific for U and A residues useful in RNA sequence analysis". Nucleic Acids Research. 8 (14): 3133–3142. doi:10.1093/nar/8.14.3133. ISSN 0305-1048. PMC 324360. PMID 6160466.
  8. ^ Donis-Keller, Helen; Green, Phillip; Helms, Cynthia; Cartinhour, Samuel; Weiffenback, Barbara; Stephens, Karen; Keith, Tim P.; Bowden, Donald W. (October 23, 1987). "A Genetic Linkage Map of the Human Genome" (PDF). Cell. 51 (2): 319–337. doi:10.1016/0092-8674(87)90158-9. PMID 3664638. S2CID 7230640.
  9. ^ Cook-Deegan, Robert (1996). The Gene Wars: Science, Politics and the Human Genome. W. W. Norton & Company. ISBN 9780393313994.
  10. ^ Robert Mullan Cook-Deegan; Hanna, Kathi E. (1991). The Human Genome Project: The Formation of Federal Policies in the United States, 1986-1990. National Academies Press (US).
  11. ^ Group, NIH/CEPH Collaborative Mapping (1992). "A Comprehensive Genetic Linkage Map of the Human Genome". Science. 258 (5079): 67–86. doi:10.1126/science.1439770. ISSN 0036-8075. JSTOR 2885812. {{cite journal}}: |last= has generic name (help)
  12. ^ Roberts, Leslie (1988). "The Race for the Cystic Fibrosis Gene". Science. 240 (4849): 141–144. Bibcode:1988Sci...240..141R. doi:10.1126/science.3281257. ISSN 0036-8075. JSTOR 1701223. PMID 3281257.
  13. ^ Donis-Keller, Helen; Dou, Shenshen; Chi, David; Carlson, Katrin M.; Toshima, Koji; Lairmore, Terry C.; Howe, James R.; Moley, Jeffrey F.; Goodfellow, Paul; Wells, Samuel A. (1993). "Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC". Human Molecular Genetics. 2 (7): 851–856. doi:10.1093/hmg/2.7.851. ISSN 0964-6906. PMID 8103403.
  14. ^ Radford, Diane M.; Fair, Keri L.; Phillips, Nancy J.; Ritter, Jon H.; Steinbrueck, Todd; Holt, Matthew S.; Donis-Keller, Helen (1995-08-01). "Allelotyping of Ductal Carcinoma in Situ of the Breast: Deletion of Loci on 8p, 13q, 16q, 17p and 17q". Cancer Research. 55 (15): 3399–3405. ISSN 0008-5472. PMID 7614479.
  15. ^ Glass, Andrew G.; Donis-Keller, Helen; Mies, Carolyn; Russo, Jose; Zehnbauer, Barbara; Taube, Sheila; Aamodt, Roger (2001-07-01). "The Cooperative Breast Cancer Tissue Resource: Archival Tissue for the Investigation of Tumor Markers". Clinical Cancer Research. 7 (7): 1843–1849. ISSN 1078-0432. PMID 11448894.
  16. ^ "Past Honorary Degrees". Lakehead University. Retrieved 2021-09-26.
  17. ^ CULTURE, COURTESY OF NEEDHAM COUNCIL FOR ARTS AND. "Needham students, artists showcase presentations with Storefronts Needham". Wicked Local. Retrieved 2021-09-27.
  18. ^ "How Genomic - Helen Donis-Keller". www.jgsinc.org. Archived from the original on 2021-09-27. Retrieved 2021-09-27.
  19. ^ "Helen Donis-Keller – Krakow Witkin Gallery". Retrieved 2021-09-27.
  20. ^ "HELEN DONIS-KELLER, MFA 01 - Hero of the Earth, Havana - $700". smfa.bidsquare.com. Archived from the original on 2021-09-27. Retrieved 2021-09-27.
  21. ^ Johnson, Carolyn Y. (March 13, 2015). "A physicist, biologist, Nobel laureate, CEO, and now, artist - The Boston Globe". BostonGlobe.com. Retrieved 2021-09-27.
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