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Harvey Cantor

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Harvey Cantor
Harvey Cantor
Alma materColumbia University
NYU School of Medicine
Known forT cell subsets
Scientific career
FieldsImmunology
InstitutionsHarvard Medical School
Dana–Farber Cancer Institute

Harvey Cantor is an American immunologist known for his studies of the development and immunological function of T lymphocytes.[1][2] Cantor is currently the Baruj Benacerraf Professor of Immunology and Microbiology at the Harvard Medical School.

Research

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Cantor's early studies focused on the development and function of lymphocytes derived from the thymus (T-lymphocytes or T cells).[3] In particular, his research addressed whether the multiple immunological functions of T cells were invested in a single lineage or represented the specialized activities of distinct T cell subsets. This approach depended on the use of antibodies to cell surface glycoproteins or “markers” that might identify specialized subsets of lymphocytes with particular immunologic functions. This experimental approach was also used to investigate other lymphocyte populations, including “natural killer” cells. His laboratory continues to investigate the molecular and cellular elements that regulate the immune response and maintain self-tolerance in the context of autoimmune disorders, anti-tumor immunity and, more recently, Alzheimer's disease.[4][5][6][7][8][9][10][11][12][13]

Education

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Cantor received an A.B. from Columbia University and M.D. from New York University School of Medicine, followed by fellowship training at the National Institutes of Health (NIH) in Bethesda, MD with Richard Asofsky and as an NIH Special Fellow at the National Institute for Medical Research in Mill Hill, London. Following a residency in medicine at Stanford, he joined the faculty of Harvard Medical School in 1975 as an assistant professor of medicine and, since 1979, has been professor of pathology. In 1998, Cantor was appointed chair of the Department of Cancer Immunology & Virology at the Dana-Farber Cancer Institute and in 2007 he was honored by appointment to the Baruj Benacerraf Professorship at Harvard Medical School.

Awards

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Cantor was elected to the National Academy of Sciences (2002), the American Association for the Advancement of Science (2005) and the American Academy of Arts & Sciences (2010).[14] More recently, Cantor received the 2019 Excellence in Mentoring Award [15] and was elected as a Distinguished Fellow of the American Association of Immunologists in 2020.[16]

References

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  1. ^ National Academy of Sciences |http://www.nasonline.org/member-directory/members/20002178.html
  2. ^ Cooke, Robert (November 9, 1982). "Research points way to control of immune system". The Boston Globe.
  3. ^ Foreman, Judy (April 25, 1997). "Cancer researcher receives $5m award". The Boston Globe.
  4. ^ Dickman, Steven (February 27, 1998). "Viral saboteurs caught in the act". Science.
  5. ^ Leavy, Olive (October 2010). "CD8+ Treg cells join the fold". Nature Reviews Immunology. 10 (10): 680. doi:10.1038/nri2862. PMID 20879168.
  6. ^ †Hu D, †Ikizawa K, Lu L, Sanchirico ME, Shinohara ML, Cantor H. Analysis of regulatory CD8 cells in mice deficient in the Qa-1 class Ib molecule. Nature Immunology, 2004;5:516
  7. ^ Lu L, Ikizawa K, Hu D, Werneck MBF, Wucherpfennig KW, Cantor H. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity, 2007;26: 593
  8. ^ †Leavenworth JW, †Schellack C, †Kim H-J, Lu L, Spee P, and Cantor H. Analysis of the cellular mechanism underlying inhibition of EAE after treatment with anti-NKG2A F(ab)′2. Proc Natl Acad Sci USA, 2010;107:2562
  9. ^ Kim H-J, Verbinnen B, Tang X, Lu L and Cantor H. 2010. Inhibition of follicular T helper cells by CD8+ Treg is essential for self tolerance. Nature 2010;467:328
  10. ^ Kim, H-J, Wang X, Radfar S, Sproule TJ, Roopenian DC, Cantor H. CD8+ T regulatory cells express the Ly49 class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. Proc Natl Acad Sci USA 2011;108:2010
  11. ^ †Leavenworth JW, †Wang X, Wenander CS, Spee P, Cantor H. Mobilization of natural killer cells inhibits development of collagen-induced arthritis. Proc Natl Acad Sci USA 2011;108:14584
  12. ^ Leavenworth JW, Tang X, Kim HJ, Wang X, Cantor H. Amelioration of arthritis through mobilization of CD8+ regulatory T cells. J Clin Invest, 2013;123:1382-9
  13. ^ Steinman L. An intrinsically disordered protein, osteopontin, driving neuropathology in Alzheimer's dementia. Proc Natl Acad Sci U S A. 2023; 120:e2221816120. PMC9963143.
  14. ^ "Harvey Cantor". 2 July 2023.
  15. ^ "Excellence in Mentoring Awards". American Association of Immunologists. 2019.
  16. ^ "Distinguished Fellows of AAI". American Association of Immunologists. 2020.
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  • Dana-Farber Cancer Institute profile [1]
  • Dana-Farber/Harvard Cancer Center (DF/HCC) profile [2]
  • Harvard Medical School Program in Immunology profile [3]
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