Haplogroup JT
| Haplogroup JT | |
|---|---|
| Possible time of origin | 50,300 YBP |
| Possible place of origin | Southwest Asia |
| Ancestor | R2'JT |
| Descendants | J, T |
| Defining mutations | 11251, 15452A, 16126[1] |
Haplogroup JT is a human mitochondrial DNA (mtDNA) haplogroup.
Origin
[edit]Haplogroup JT is descended from the macro-haplogroup R. It is the ancestral clade to the mitochondrial haplogroups J and T.
Distribution
[edit]JT (predominantly J) was found among the ancient Etruscans.[2] The root level haplogroup JT* has been assigned to an ancient person found at the Colfiorito necropolis in Umbria in central Italy.[3]
The haplogroup has also been found among Iberomaurusian specimens dating from the Epipaleolithic at the Taforalt prehistoric site.[4] One ancient individual carried a haplotype, which correlates with either the JT clade or the haplogroup H subclade H14b1 (1/9; 11%).[5]
Subclades
[edit]Tree
[edit]This phylogenetic tree of haplogroup JT subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[1] and subsequent published research.
Health
[edit]Maternally inherited ancient mtDNA variants have clear impact on the presentation of disease in a modern society. Superhaplogroup JT is an example of reduced risk of Parkinson's disease[6] And mitochondrial and mtDNa alterations continue to be promising disease biomarkers.[7][8]
See also
[edit]|
Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups | |||||||||||||||||||||||||||||||||||||||
| Mitochondrial Eve (L) | |||||||||||||||||||||||||||||||||||||||
| L0 | L1–6 | ||||||||||||||||||||||||||||||||||||||
| L1 | L2 | L3 | L4 | L5 | L6 | ||||||||||||||||||||||||||||||||||
| M | N | ||||||||||||||||||||||||||||||||||||||
| CZ | D | E | G | Q | O | A | S | R | I | W | X | Y | |||||||||||||||||||||||||||
| C | Z | B | F | R0 | pre-JT | P | U | ||||||||||||||||||||||||||||||||
| HV | JT | K | |||||||||||||||||||||||||||||||||||||
| H | V | J | T | ||||||||||||||||||||||||||||||||||||
References
[edit]- ^ a b van Oven, Mannis; Manfred Kayser (13 Oct 2008). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–E394. doi:10.1002/humu.20921. PMID 18853457.
- ^ "We Are Not Our Ancestors". Archived from the original on 2009-04-08. Retrieved 2012-02-10.
- ^ GenBank Accession number: MN687309.1
- ^ Bernard Secher; Rosa Fregel; José M Larruga; Vicente M Cabrera; Phillip Endicott; José J Pestano; Ana M González (2014). "The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents". BMC Evolutionary Biology. 14 (1): 109. Bibcode:2014BMCEE..14..109S. doi:10.1186/1471-2148-14-109. PMC 4062890. PMID 24885141.
- ^ Kefi, Rym; et al. (2016). "On the origin of Iberomaurusians: new data based on ancient mitochondrial DNA and phylogenetic analysis of Afalou and Taforalt populations". Mitochondrial DNA Part A. 29 (1): 147–157. doi:10.1080/24701394.2016.1258406. PMID 28034339. S2CID 4490910.
- ^ Marom S, Friger M, Mishmar D (February 2017). "MtDNA meta-analysis reveals both phenotype specificity and allele heterogeneity: a model for differential association". Sci Rep. 7: 43449. doi:10.1038/srep43449. PMC 5322532. PMID 28230165.
- ^ Martín-Jiménez R, Lurette O, Hebert-Chatelain E (August 2020). "Damage in Mitochondrial DNA Associated with Parkinson's Disease". DNA Cell Biol. 39 (8): 1421–1430. doi:10.1089/dna.2020.5398. PMID 32397749.
- ^ Lowes H, Pyle A, Duddy M, Hudson G (May 2019). "Cell-free mitochondrial DNA in progressive multiple sclerosis". Mitochondrion. 46: 307–312. doi:10.1016/j.mito.2018.07.008. PMC 6509276. PMID 30098422.
External links
[edit]- General
- Ian Logan's Mitochondrial DNA Site
- Mannis van Oven's Phylotree
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