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Hans Kosterlitz

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Hans Kosterlitz
Born
Hans Walter Kosterlitz

(1903-04-27)27 April 1903
Berlin
Died26 October 1996(1996-10-26) (aged 93)
NationalityBritish, German (before 1933)
Alma materHumboldt University of Berlin
Known forEndorphins
SpouseJohanna Greßhöner
AwardsHarvey Prize (1981)
Fellow of the Royal Society (1978)[1]
Royal Medal (1979)
Cameron Prize for Therapeutics of the University of Edinburgh (1988)
Scientific career
FieldsBiochemistry
InstitutionsUniversity of Aberdeen

Hans Walter Kosterlitz FRS[1] (27 April 1903 – 26 October 1996) was a German-born British biochemist.

Biography

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Hans Walter Kosterlitz was born on 27 April 1903 in Berlin.[2] He was the elder son of Bernhard Kosterlitz, a physician, and Selma Helena Lepman.

Kosterlitz's father had recommended a career in law. He gave it a try for six months at the University of Berlin, but then switched to medicine. He graduated in 1928 and worked in the department of Wilhelm His. From 1930 to 1933 he was an assistant at the Charité hospital, University of Berlin,[3] where he worked in the radiology department. His daytime job in clinical radiology funded his evening researches in the laboratory, where he developed an interest in carbohydrate metabolism.

In 1933 Adolf Hitler passed the Law for the Restoration of the Professional Civil Service, which applied to non-Aryans. Later a similar law was passed to cover all lawyers, doctors and other professions. Kosterlitz, who had Jewish ancestry, contacted John Macleod, FRS in Aberdeen, who managed to accumulate some modest funding, sufficient for him to reply ‘come to Aberdeen … but no guarantee of a secure job’.[1] Kosterlitz arrived the following March.

Soon after Macleod's untimely death on 16 March 1935, Kosterlitz was awarded the first ever project grant (£50) from the newly founded Diabetic Association. He later received his first grant from the MRC.

On 9 March 1937 he married Johanna Maria Katharina Greßhöner, known as Hanna, a friend from Berlin who had arrived in Scotland in 1935.[4] Both Kosterlitz parents and their younger son Rolf moved to the UK in 1939, and lived at 110b Banbury Road, Oxford. The 1939 National Register shows Bernhard as a medical referee for an insurance company. Hans and Hanna had a son, John Michael, now Professor of Physics at Brown University, who won the Nobel Prize in Physics in 2016.

Over the years Hans Kosterlitz was a Carnegie Teaching Fellow, Lecturer, Senior Lecturer, and finally Reader. In 1968, Aberdeen established a new Department of Pharmacology, which was headed by Kosterlitz as professor until 1973, when he became director of the university's drug addiction research unit.[5][6]

Kosterlitz is best known for his work as one of the key discoverers of endorphins.[7][8] He stimulated the mouse isolated vas deferens electrically and recorded its contractions with a polygraph. He then found that if you added opiates to the solution, the muscle would not contract. Opiates inhibited the contraction. Those contractions were later found to resume in the presence of both opiates and an antagonist such as naloxone. Later, endogenous endorphins were discovered by applying pig brain cell homegenate to the apparatus. This caused the contractions to cease. The degree to which an opiate agonist inhibits contractions of the mouse vas deferens, and other tissues like the guinea pig ileum, is highly correlated to its potency as an analgesic.

Awards, honours and tribute

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In his 1998 tribute, former colleague and friend Dr Gordon M Lees said of Kosterlitz

“[He] was a quiet, rather modest man, who was greatly respected, both as a scientist and as a person of real courage, honour, judgement, polite manners, and inflexible integrity of conduct and consistency of principle.”[12]

References

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  1. ^ a b c North, R. A.; Hughes, J. (2013). "Hans Walter Kosterlitz. 27 April 1903 -- 26 October 1996". Biographical Memoirs of Fellows of the Royal Society. 59: 171–192. doi:10.1098/rsbm.2012.0037.
  2. ^ Berlin, Deutschland, Geburtsregister, 1874-1906 [Ancestry]
  3. ^ Anonymous (1993). Displaced German scholars : a guide to academics in peril in Nazi Germany during the 1930s. San Bernardino: Borgo Press. ISBN 0-89370-474-1.
  4. ^ Marriage certificate
  5. ^ Lees, G. M. (1998). "A tribute to the late Hans W. Kosterlitz: Ploughing the lone furrow". Canadian Journal of Physiology and Pharmacology. 76 (3): 244–251. doi:10.1139/cjpp-76-3-244. PMID 9673787.
  6. ^ Hughes, J. (1996). "Hans Kosterlitz (1903–96)". Nature. 384 (6608): 418. Bibcode:1996Natur.384..418H. doi:10.1038/384418a0. PMID 8945465. S2CID 7862511.
  7. ^ Hughes, J.; Kosterlitz, H.W.; Smith, T.W. (1977). "The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues". British Journal of Pharmacology. 61 (4): 639–647. doi:10.1111/j.1476-5381.1977.tb07557.x. ISSN 0007-1188. PMC 1668063. PMID 597668.
  8. ^ Henderson, G.; Hughes, J.; Kosterlitz, H. W. (1972). "A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens". British Journal of Pharmacology. 46 (4): 764–766. doi:10.1111/j.1476-5381.1972.tb06901.x. ISSN 0007-1188. PMC 1666368. PMID 4655272.
  9. ^ Albert Lasker Basic Medical Research Award 1978
  10. ^ Announcements. Nature 302, 463–464 (1983)
  11. ^ "New centre to bring life science academics and industry closer together". University of Aberdeen. 1 October 2019. Retrieved 20 April 2020.
  12. ^ Lees, G M (1998). "A tribute to the late Hans W. Kosterlitz: ploughing the lone furrow". Canadian Journal of Physiology and Pharmacology. 76 (3): 244–51. doi:10.1139/y98-024. PMID 9673787.
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