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Hanneke Schuitemaker

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Hanneke Schuitemaker
Born1964 (age 59–60)
Netherlands
Scientific career
InstitutionsUniversity of Amsterdam
Sanquin
Amsterdam University Medical Centers
Crucell
ThesisRole of HIV-1 monocytotropism in AIDS pathogenesis (1992)

Hanneke Schuitemaker is a Dutch virologist, the Global Head of Viral Vaccine Discovery and Translational Medicine at Johnson & Johnson's Janssen Vaccines & Prevention, and a Professor of Virology at the Amsterdam University Medical Centers of the University of Amsterdam (since 2004). She has been involved in the development of Janssen's Ebola vaccine and is involved in the development of a universal flu vaccine, HIV vaccine, RSV vaccine and COVID-19 vaccine.

Early life and education

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Schuitemaker (1964) grew up in the Netherlands.[1] Her mother was a bookkeeper and her father was an electrical engineer.[1] As a child she was fascinated by medicine, and after earning her undergraduate degree she completed a PhD programme in AIDS pathogenesis at the University of Amsterdam.[1]

Research and career

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Schuitemaker started to research HIV/AIDS in 1989.[1] Whilst interested in the virus itself, Schuitemaker also wanted to learn more about the patients who suffered from the disease, and took part in a patient outreach program. Her interactions in this program strengthened her motivation to better understand the disease, help find a vaccine and treatments. She studied the pathogenesis of HIV-1 throughout her career. Her early research focussed on whether HIV could infect other cells in the body than just T cells, including cells in the brain and lungs.[1] She started working at Sanquin, the Netherlands blood supply foundation based in Amsterdam, where she was made Head of the department of Clinical Viro-Immunology in 1998. Schuitemaker has been involved in policy, and has held advisory positions on several vaccine charities. From 2003 to 2004, she was a visiting scientist at the La Jolla Scripps Research Institute.[2]

Schuitemaker joined the Academic Medical Center in Amsterdam in 2008, where she was made Chair of Experimental Immunology.[2] She moved to Crucell in 2010, which, at the time, was an independent biotechnology company.[3] Two weeks later, Crucell was acquired by Janssen Vaccines, part of Johnson & Johnson.[3] She was appointed Global Head of Viral Vaccines Discovery and Translational Medicine.[4] At Janssen, Schuitemaker worked on the universal flu vaccine.[5] She returned to working on vaccinations to protect against HIV-1.[6] Schuitemaker demonstrated the efficacy of the adenovirus/protein vaccines against simian immunodeficiency virus in rhesus macaques.[7][8] In 2018, Schuitemaker's vaccine regime was shown to induce an immune response to HIV in humans.[1][9] Results of Imbokodo, an investigation into the potential for this vaccine to save the lives of thousands of young women in Sub-Saharan Africa, are expected in 2021.[1][10] Another study, Mosaico, will see 3,800 individuals taking part in a Phase 3 clinical trial of the vaccine.[11]

During the COVID-19 pandemic Janssen looked to develop a COVID-19 vaccine.[12][13][14][15] Their approach started with a single viral genome, which was being tested as of March 2020.[12] Schuitemaker estimated that it would take between 12 and 18 months to manufacture a vaccine.[12][16]

Early in the COVID-19 pandemic, Schuitemaker announced Johnson & Johnson's ambition to develop a vaccine against the unknown infectious disease. Her team's approach started with the discovery of the genetic code of SARS-CoV-2, the cause of the disease COVID-19. The various vaccine candidates have been tested from March 2020. In mid-May, she announced that Janssen's most hopeful vaccine variant will be tested on humans in July 2020. In November 2020, Jansen Vaccines announced that the production of the COVID vaccine was delayed by several months due to the occurrence of an unknown disease in one test subject in phase 3. The US regulator FDA approved the Johnson & Johnson COVID-19 vaccine for use on February 27, 2021. Approval by the European Medicines Agency was given on March 11.

Selected publications

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  • Fouchier, R A; Groenink, M; Kootstra, N A; Tersmette, M; Huisman, H G; Miedema, F; Schuitemaker, H (1992). "Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule". Journal of Virology. 66 (5): 3183–3187. doi:10.1128/jvi.66.5.3183-3187.1992. ISSN 0022-538X. PMC 241084. PMID 1560543.
  • van't Wout, A B; Kootstra, N A; Mulder-Kampinga, G A; Albrecht-van Lent, N; Scherpbier, H J; Veenstra, J; Boer, K; Coutinho, R A; Miedema, F; Schuitemaker, H (1994-11-01). "Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission". Journal of Clinical Investigation. 94 (5): 2060–2067. doi:10.1172/jci117560. ISSN 0021-9738. PMC 294642. PMID 7962552.
  • "Glycan recognition on HIV env by broadly neutralizing antibodies (bNAbs)". Science-Business EXchange. 7 (40): 1192. 2014. doi:10.1038/scibx.2014.1192. ISSN 1945-3477.

Personal life

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Schuitemaker has three sons.[2]

References

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  1. ^ a b c d e f g "Meet a Johnson & Johnson Researcher Poised to Crack the HIV Vaccine Code". Content Lab U.S. 2018-07-23. Retrieved 2020-03-22.
  2. ^ a b c "Hanneke Schuitemaker". ECSJ2017. 2017-06-25. Archived from the original on 2020-03-22. Retrieved 2020-03-22.
  3. ^ a b Schofield, Amy (2018-03-14). "Women of pharma: Hanneke Schuitemaker". Pharmafield. Retrieved 2020-03-22.
  4. ^ "MENS #11: Hanneke Schuitemaker". Vrij Nederland (in Dutch). 2020-01-30. Retrieved 2020-03-22.
  5. ^ Sample, Ian (2015-08-24). "Universal flu vaccine a step closer as scientists create experimental jabs". The Guardian. ISSN 0261-3077. Retrieved 2020-03-22.
  6. ^ Ramsey, Lydia. "9 dangerous diseases that could be prevented by vaccines within the next decade, from HIV to cancer". Business Insider. Retrieved 2020-03-22.
  7. ^ Barouch, Dan H.; Alter, Galit; Broge, Thomas; Linde, Caitlyn; Ackerman, Margaret E.; Brown, Eric P.; Borducchi, Erica N.; Smith, Kaitlin M.; Nkolola, Joseph P.; Liu, Jinyan; Shields, Jennifer (2015-07-17). "Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys". Science. 349 (6245): 320–324. Bibcode:2015Sci...349..320B. doi:10.1126/science.aab3886. ISSN 0036-8075. PMC 4653134. PMID 26138104.
  8. ^ Poli, Guido (2018-07-16). "Un vaccino antiHIV, sogno o realtà?". Scienza in rete (in Italian). Retrieved 2020-03-22.
  9. ^ "Johnson & Johnson is about to test an experimental HIV vaccine on thousands of people". Los Angeles Times. 2019-07-12. Retrieved 2020-03-22.
  10. ^ "Once feared HIV drug gets WHO nod". The East African. Archived from the original on 2020-02-12. Retrieved 2020-03-22.
  11. ^ ""MOSAIC" HIV Vaccine to be Tested in Thousands Globally". Biopharma from Technology Networks. Retrieved 2020-03-22.
  12. ^ a b c McKie, Robin (2020-03-21). "Vaccine scientist: 'Everything is so new in dealing with this coronavirus'". The Observer. ISSN 0029-7712. Retrieved 2020-03-22.
  13. ^ "Johnson & Johnson tests 10 variants of coronavirus vaccine". Nikkei Asian Review. Retrieved 2020-03-22.
  14. ^ Lee, Georgina (17 March 2020). "FactCheck: how close are we to a vaccine or cure for coronavirus?". Channel 4 News. Retrieved 2020-03-22.
  15. ^ Andy Extance2020-02-11T14:30:00+00:00. "The race to fight coronavirus". Chemistry World. Retrieved 2020-03-22.{{cite web}}: CS1 maint: numeric names: authors list (link)
  16. ^ Belluz, Julia (2020-03-04). "A simple guide to the vaccines and drugs that could fight coronavirus". Vox. Retrieved 2020-03-22.
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