HSD17B11

HSD17B11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YB1
Identifiers
Aliases	HSD17B11, 17-BETA-HSD11, 17-BETA-HSDXI, 17BHSD11, DHRS8, PAN1B, RETSDR2, SDR16C2, hydroxysteroid (17-beta) dehydrogenase 11, hydroxysteroid 17-beta dehydrogenase 11
External IDs	OMIM: 612831; MGI: 2149821; HomoloGene: 69209; GeneCards: HSD17B11; OMA:HSD17B11 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	87,391,188 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	104,169,785 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of colon; ; duodenum; ; mucosa of sigmoid colon; ; rectum; ; mucosa of ileum; ; monocyte; ; gallbladder; ; mucosa of transverse colon; ; blood;
	Top expressed in
	vestibular membrane of cochlear duct; ; pyloric antrum; ; epithelium of stomach; ; mucous cell of stomach; ; iris; ; intestinal villus; ; stria vascularis; ; Ileal epithelium; ; left lobe of liver; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; steroid dehydrogenase activity; estradiol 17-beta-dehydrogenase activity;
Cellular component	cytoplasm; extracellular region; cytosol; lipid droplet;
Biological process	estrogen biosynthetic process; androgen catabolic process; lipid metabolism; steroid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	51170
	114664
	ENSG00000198189
	ENSMUSG00000029311
	Q8NBQ5
	Q9EQ06
	NM_016245
	NM_053262
	NP_057329
	NP_444492
	Wikidata
View/Edit Human	View/Edit Mouse

Estradiol 17-beta-dehydrogenase 11 is an enzyme that in humans is encoded by the HSD17B11 gene.^[5]^[6]^[7]^[8]

HSD17B11 expression has been linked to higher survival rates for lung cancer patients.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198189 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029311 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z (January 2001). "Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung". Molecular and Cellular Endocrinology. 171 (1–2): 111–7. doi:10.1016/S0303-7207(00)00417-2. PMID 11165019. S2CID 54263651.
^ Chai Z, Brereton P, Suzuki T, Sasano H, Obeyesekere V, Escher G, Saffery R, Fuller P, Enriquez C, Krozowski Z (May 2003). "17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells". Endocrinology. 144 (5): 2084–91. doi:10.1210/en.2002-221030. PMID 12697717.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (March 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ "Entrez Gene: HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11".
^ "Research update from the MCM team (March 2024)". World Community Grid. 14 March 2024. Retrieved 21 May 2024.

Li KX, Smith RE, Krozowski ZS (1999). "Cloning and expression of a novel tissue specific 17beta-hydroxysteroid dehydrogenase". Endocrine Research. 24 (3–4): 663–7. doi:10.3109/07435809809032667. PMID 9888557.
Haeseleer F, Palczewski K (2000). "Short-chain dehydrogenases/Reductases in retina". Vertebrate Phototransduction and the Visual Cycle, Part B. Methods in Enzymology. Vol. 316. pp. 372–83. doi:10.1016/S0076-6879(00)16736-9. ISBN 978-0-12-182217-0. PMID 10800688.
Hartmann TB, Thiel D, Dummer R, Schadendorf D, Eichmüller S (February 2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma". The British Journal of Dermatology. 150 (2): 252–8. doi:10.1111/j.1365-2133.2004.05651.x. PMID 14996095. S2CID 42495130.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198189 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029311 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11165019-5] Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z (January 2001). "Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung". Molecular and Cellular Endocrinology. 171 (1–2): 111–7. doi:10.1016/S0303-7207(00)00417-2. PMID 11165019. S2CID 54263651.

[pmid12697717-6] Chai Z, Brereton P, Suzuki T, Sasano H, Obeyesekere V, Escher G, Saffery R, Fuller P, Enriquez C, Krozowski Z (May 2003). "17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells". Endocrinology. 144 (5): 2084–91. doi:10.1210/en.2002-221030. PMID 12697717.

[pmid19027726-7] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (March 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[entrez-8] "Entrez Gene: HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11".

[9] "Research update from the MCM team (March 2024)". World Community Grid. 14 March 2024. Retrieved 21 May 2024.

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References

Further reading