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Enzyme
Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene .[ 5] [ 6]
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes heparan sulfate 2-O-sulfotransferase , a member of the heparan sulfate biosynthetic enzyme family. This family member transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate.
The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000153936 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040151 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain" . DNA Res . 4 (5): 345–9. doi :10.1093/dnares/4.5.345 PMID 9455484 . ^ a b "Entrez Gene: HS2ST1 heparan sulfate 2-O-sulfotransferase 1" .
Muramatsu T (2000). "Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting" . J. Biochem . 127 (2): 171–6. doi :10.1093/oxfordjournals.jbchem.a022590 PMID 10731680 . Rong J, Habuchi H, Kimata K, et al. (2000). "Expression of heparan sulphate L-iduronyl 2-O-sulphotransferase in human kidney 293 cells results in increased D-glucuronyl 2-O-sulphation" . Biochem. J . 346 (2): 463–8. doi :10.1042/0264-6021:3460463 . PMC 1220874 PMID 10677367 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Aquino RS, Landeira-Fernandez AM, Valente AP, et al. (2005). "Occurrence of sulfated galactans in marine angiosperms: evolutionary implications" . Glycobiology . 15 (1): 11–20. doi :10.1093/glycob/cwh138 PMID 15317737 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 . Xu D, Song D, Pedersen LC, Liu J (2007). "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase" . J. Biol. Chem . 282 (11): 8356–67. doi :10.1074/jbc.M608062200 PMID 17227754 .
