HLA-B52


B*5101-β2MG with bound peptide 1e27




major histocompatibility complex (human), class I, B52
Alleles	B*5201, 5202, 5203, . . .
Structure (See HLA-B)
Shared data
Locus	chr.6 6p21.31

HLA-B52 (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products.^[1]

B52 is a split antigen of the broad antigen B5, and is a sister type of B51. B*5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B*5101.^[2] There are a number of alleles within the B*52 allele group.^[3]

Serotype

Serotypes B52, B5, B51, and B53 recognition of HLA B*5201 gene product^[4]
B*52	B52	B5	B51	B53	Sample
allele	%	%	%	%	size (N)
*5201	84	2	7	1	2823
Alleles link-out to IMGT/HLA Databease at EBI

**HLA *5201 frequencies**
		freq
ref.	Population	(%)
^[5]	China Yunnan Lisu	21.7
^[5]	China Yunnan Nu	18.6
^[5]	Bulgaria Gipsy	18.2
^[5]	Venezuela Sierra de Perija Yucpa	12.8
^[5]	India Andhra Pradesh Golla	12.0
^[5]	Japan Central	10.7
^[5]	Japan	10.4
^[5]	Georgia Tbilisi Kurds	10.3
^[5]	Mali Bandiagara	8.3
^[5]	South Africa Natal Tamil	8.2
^[5]	Israel Ashk. and Non-Ashk. Jews	7.3
^[5]	India North Hindus	6.7
^[5]	China Beijing	6.1
^[5]	India New Delhi	6.1
^[5]	India Mumbai Marathas	5.6
^[5]	Tunisia Ghannouch	5.5
^[5]	Thailand pop3	5.1
^[5]	India West Coast Parsis	5.0
^[5]	India North Delhi	4.9
^[5]	Mexico Mestizos	4.9
^[5]	Argentina Toba Rosario	4.7
^[5]	Mexico Zaptotec Oaxaca	4.5
^[5]	USA Hispanic	4.5
^[5]	China Qinghai Hui	4.1
^[5]	China Inner Mongolia	3.9
^[5]	China North Han	3.8
^[5]	Oman	3.8
^[5]	Senegal Niokholo Mandenka	3.7
^[5]	Bulgaria	3.6
^[5]	Thailand	3.5
^[5]	Ivory Coast Akan Adiopodoume	3.4
^[5]	Venezuela Perja Mountain Bari	3.4
^[5]	Italy North pop 1	3.3
^[5]	Sudanese	3.3
^[5]	Romanian	3.2
^[5]	Singapore Riau Malay	3.0
^[5]	Autonomous Region Tibetans	2.8
^[5]	Russia Tuva pop 2	2.8
^[5]	South Korea pop 3	2.8
^[5]	Iran Baloch	2.5
^[5]	Tunisia	2.5
^[5]	Jordan Amman	2.4
^[5]	USA Hawaii Okinawa	2.4
^[5]	Singapore Javanese Indonesians	2.0
^[5]	Spain Eastern Andalusia	1.8
^[5]	Macedonia pop 4	1.6
^[5]	Uganda Kampala	1.6
^[5]	Belgium	1.5
^[5]	Mexico Guadalajara Mestizos pop2	1.5
^[5]	Singapore Thai	1.5
^[5]	Brazil	1.4
^[5]	China Yunnan Lisu	1.4
^[5]	Azores Santa Maria and Sao Miguel	1.3
^[5]	France South East	1.2
^[5]	Italy North Pavia	1.2
^[5]	Saudi Arabia Guraiat and Hail	1.2
^[5]	Mexico Chihuahua State Tarahumara	1.1
^[5]	Tunisia Tunis	1.1
^[5]	Israel Arab Druse	1.0
^[5]	Japan Ainu Hokkaido	1.0
^[5]	Portugal Centre	1.0
^[5]	Singapore Chinese	1.0
^[5]	Taiwan Minnan pop 1	1.0
^[5]	USA Caucasian	1.0
^[5]	Azores Central Islands	0.9
^[5]	China South Han	0.9
^[5]	Macedonia pop 4	0.7
^[5]	Morocco Nador Metalsa Class I	0.7
^[5]	Georgia Svaneti Svans	0.6
^[5]	Ireland South	0.6
^[5]	Italy Bergamo	0.6

Alleles

There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B*5201 is the most common, but others have a large regional abundance.

Disease

In ulcerative colitis

HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan.^[6]^[7] This form of disease is frequently found with Takayasu's arteritis.^[8]^[9]

In Takayasu's arteritis

Takayasu's arteritis appears to have an independent link to B52 associated disease.^[10]^[11] The association with B*5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance.^[12]

References

^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
^ Cox ST, McWhinnie AJ, Robinson J, et al. (January 2003). "Cloning and sequencing full-length HLA-B and -C genes" (PDF). Tissue Antigens. 61 (1): 20–48. doi:10.1034/j.1399-0039.2003.610103.x. PMID 12622774. Archived from the original (PDF) on 2008-10-28. Retrieved 2008-08-03.
^ Hayashi H, Ennis PD, Ariga H, et al. (January 1989). "HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain". J. Immunol. 142 (1): 306–11. PMID 2909619.
^ derived from IMGT/HLA
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x ^y ^z ^aa ^ab ^ac ^ad ^ae ^af ^ag ^ah ^ai ^aj ^ak ^al ^am ^an ^ao ^ap ^aq ^ar ^as ^at ^au ^av ^aw ^ax ^ay ^az ^ba ^bb ^bc ^bd ^be ^bf ^bg ^bh ^bi ^bj ^bk ^bl ^bm ^bn ^bo ^bp ^bq ^br ^bs Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
^ Sugimura K, Asakura H, Mizuki N, et al. (February 1993). "Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis". Hum. Immunol. 36 (2): 112–8. doi:10.1016/0198-8859(93)90113-F. PMID 8096500.
^ Nomura E, Kinouchi Y, Negoro K, et al. (September 2004). "Mapping of a disease susceptibility locus in chromosome 6p in Japanese patients with ulcerative colitis". Genes Immun. 5 (6): 477–83. doi:10.1038/sj.gene.6364114. PMID 15215890.
^ Oyanagi, Hironobu; Ishihata, R; Ishikawa, H; et al. (February 1994), "Ulcerative colitis associated with Takayasu's disease", Intern. Med., 33 (2): 127–129, doi:10.2169/internalmedicine.33.127, PMID 7912572
^ Sato, R; Sato, Y; Ishikawa, H; et al. (December 1994), "Takayasu's disease associated with ulcerative colitis", Intern. Med., 33 (12): 759–763, doi:10.2169/internalmedicine.33.759, PMID 7718956
^ Kimura A, Kitamura H, Date Y, Numano F (August 1996). "Comprehensive analysis of HLA genes in Takayasu arteritis in Japan". Int. J. Cardiol. 54 Suppl: S61–9. doi:10.1016/s0167-5273(96)88774-2. PMID 9119528.
^ Yoshida M, Kimura A, Katsuragi K, Numano F, Sasazuki T (August 1993). "DNA typing of HLA-B gene in Takayasu's arteritis". Tissue Antigens. 42 (2): 87–90. doi:10.1111/j.1399-0039.1993.tb02242.x. PMID 7903491.
^ Kitamura H, Kobayashi Y, Kimura A, Numano F (October 1998). "Association of clinical manifestations with HLA-B alleles in Takayasu arteritis". Int. J. Cardiol. 66 Suppl 1: S121–6. doi:10.1016/S0167-5273(98)00159-4. PMID 9951811.

[pmid15787720-1] Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.

[pmid12622774-2] Cox ST, McWhinnie AJ, Robinson J, et al. (January 2003). "Cloning and sequencing full-length HLA-B and -C genes" (PDF). Tissue Antigens. 61 (1): 20–48. doi:10.1034/j.1399-0039.2003.610103.x. PMID 12622774. Archived from the original (PDF) on 2008-10-28. Retrieved 2008-08-03.

[pmid2909619-3] Hayashi H, Ennis PD, Ariga H, et al. (January 1989). "HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain". J. Immunol. 142 (1): 306–11. PMID 2909619.

[4] rived from IMGT/HLA

[pmid12753660-5] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x ^y ^z ^aa ^ab ^ac ^ad ^ae ^af ^ag ^ah ^ai ^aj ^ak ^al ^am ^an ^ao ^ap ^aq ^ar ^as ^at ^au ^av ^aw ^ax ^ay ^az ^ba ^bb ^bc ^bd ^be ^bf ^bg ^bh ^bi ^bj ^bk ^bl ^bm ^bn ^bo ^bp ^bq ^br ^bs Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.

[pmid8096500-6] Sugimura K, Asakura H, Mizuki N, et al. (February 1993). "Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis". Hum. Immunol. 36 (2): 112–8. doi:10.1016/0198-8859(93)90113-F. PMID 8096500.

[pmid15215890-7] Nomura E, Kinouchi Y, Negoro K, et al. (September 2004). "Mapping of a disease susceptibility locus in chromosome 6p in Japanese patients with ulcerative colitis". Genes Immun. 5 (6): 477–83. doi:10.1038/sj.gene.6364114. PMID 15215890.

[pmid7912572-8] Oyanagi, Hironobu; Ishihata, R; Ishikawa, H; et al. (February 1994), "Ulcerative colitis associated with Takayasu's disease", Intern. Med., 33 (2): 127–129, doi:10.2169/internalmedicine.33.127, PMID 7912572

[pmid7718956-9] Sato, R; Sato, Y; Ishikawa, H; et al. (December 1994), "Takayasu's disease associated with ulcerative colitis", Intern. Med., 33 (12): 759–763, doi:10.2169/internalmedicine.33.759, PMID 7718956

[pmid9119528-10] Kimura A, Kitamura H, Date Y, Numano F (August 1996). "Comprehensive analysis of HLA genes in Takayasu arteritis in Japan". Int. J. Cardiol. 54 Suppl: S61–9. doi:10.1016/s0167-5273(96)88774-2. PMID 9119528.

[pmid7903491-11] Yoshida M, Kimura A, Katsuragi K, Numano F, Sasazuki T (August 1993). "DNA typing of HLA-B gene in Takayasu's arteritis". Tissue Antigens. 42 (2): 87–90. doi:10.1111/j.1399-0039.1993.tb02242.x. PMID 7903491.

[pmid9951811-12] Kitamura H, Kobayashi Y, Kimura A, Numano F (October 1998). "Association of clinical manifestations with HLA-B alleles in Takayasu arteritis". Int. J. Cardiol. 66 Suppl 1: S121–6. doi:10.1016/S0167-5273(98)00159-4. PMID 9951811.

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