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HIST1H2BA

From Wikipedia, the free encyclopedia
H2BC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH2BC1, H2BFU, STBP, TSH2B, TSH2B.1, bA317E16.3, TH2B, histone cluster 1, H2ba, histone cluster 1 H2B family member a, hTSH2B, HIST1H2BA, H2B clustered histone 1
External IDsOMIM: 609904; MGI: 2448375; HomoloGene: 69356; GeneCards: H2BC1; OMA:H2BC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_170610

NM_175663

RefSeq (protein)

NP_733759

NP_783594

Location (UCSC)Chr 6: 25.73 – 25.73 MbChr 13: 24.12 – 24.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H2B type 1-A is a protein that in humans is encoded by the HIST1H2BA gene.[5][6][7]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146047Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050799Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  6. ^ Zalensky AO, Siino JS, Gineitis AA, Zalenskaya IA, Tomilin NV, Yau P, Bradbury EM (Nov 2002). "Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization". J Biol Chem. 277 (45): 43474–80. doi:10.1074/jbc.M206065200. PMID 12213818.
  7. ^ a b "Entrez Gene: HIST1H2BA histone cluster 1, H2ba".

Further reading

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