HIST1H1C

H1-2
Identifiers
Aliases	H1-2, H1.2, H1C, H1F2, H1s-1, histone cluster 1, H1c, histone cluster 1 H1 family member c, HIST1H1C, H1.2 linker histone, cluster member
External IDs	OMIM: 142710; MGI: 1931526; HomoloGene: 68455; GeneCards: H1-2; OMA:H1-2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.2 Start 26,055,740 bp End 26,056,470 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A3.1 Start 23,922,791 bp End 23,924,350 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon mucosa of transverse colon epithelium of colon apex of heart gastrocnemius muscle muscle of thigh right uterine tube left ventricle gonad right lobe of liver Top expressed in calvaria Epithelium of choroid plexus left colon ankle blood stroma of bone marrow vastus lateralis muscle triceps brachii muscle seminal vesicula submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding chromatin DNA binding protein binding RNA binding double-stranded DNA binding nucleosomal DNA binding Cellular component nucleosome nucleus chromosome Biological process regulation of transcription by RNA polymerase II histone H3-K4 trimethylation nucleosome assembly negative regulation of transcription by RNA polymerase II histone H3-K27 trimethylation regulation of transcription, DNA-templated chromosome condensation negative regulation of DNA recombination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3006 50708 Ensembl ENSG00000187837 ENSMUSG00000036181 UniProt P16403 P15864 RefSeq (mRNA) NM_005319 NM_015786 RefSeq (protein) NP_005310 NP_056601 Location (UCSC) Chr 6: 26.06 – 26.06 Mb Chr 13: 23.92 – 23.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Histone H1.2 is a protein that in humans is encoded by the HIST1H1C gene.

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Apart from its roles in the nucleus, histone H1.2 also participates in apoptosis. In response to apoptotic stimuli, mainly DNA damage, it is translocated from the nucleus to the cytosol. There, it activates Bak, a pro-apoptotic protein bound to the mithochondria outer membrane (MOM). Activation of Bak causes the perforation of the mitochondria, a process known as MOMP (mitochondria outer membrane permeabilization) which promotes apoptosis. Histone H1.2 also forms a complex with the apoptosome, possibly regulating its formation.

Further reading

• Ohe Y, Hayashi H, Iwai K (1990). "Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d". J. Biochem. 106 (5): 844–57. doi:10.1093/oxfordjournals.jbchem.a122941. PMID 2613692.
• Eilers A, Bouterfa H, Triebe S, Doenecke D (1994). "Role of a distal promoter element in the S-phase control of the human H1.2 histone gene transcription". Eur. J. Biochem. 223 (2): 567–74. doi:10.1111/j.1432-1033.1994.tb19026.x. PMID 8055927.
• Albig W, Drabent B, Kunz J, et al. (1993). "All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6". Genomics. 16 (3): 649–54. doi:10.1006/geno.1993.1243. PMID 8325638.
• Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
• Richardson RT, Batova IN, Widgren EE, et al. (2000). "Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein". J. Biol. Chem. 275 (39): 30378–86. doi:10.1074/jbc.M003781200. PMID 10893414.
• Parseghian MH, Newcomb RL, Winokur ST, Hamkalo BA (2001). "The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts". Chromosome Res. 8 (5): 405–24. doi:10.1023/A:1009262819961. PMID 10997781. S2CID 28425496.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Garcia BA, Busby SA, Barber CM, et al. (2005). "Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry". J. Proteome Res. 3 (6): 1219–27. doi:10.1021/pr0498887. PMID 15595731.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Duce JA, Smith DP, Blake RE, et al. (2006). "Linker histone H1 binds to disease associated amyloid-like fibrils". J. Mol. Biol. 361 (3): 493–505. doi:10.1016/j.jmb.2006.06.038. PMID 16854430.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.