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HEPN domain

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HEPN domain
crystal structure of tt1696 from thermus thermophilus hb8
Identifiers
SymbolHEPN
PfamPF05168
Pfam clanCL0291
InterProIPR007842
SCOP21o3u / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology, the HEPN domain (higher eukaryotes and prokaryotes nucleotide-binding domain) is a region of approximately 110 amino acids found in the C terminus of sacsin, a chaperonin implicated in an early-onset neurodegenerative disease in human, and in many bacterial and archaea proteins. There are three classes of proteins with HEPN domains:

References

[edit]
  1. ^ Grynberg M, Erlandsen H, Godzik A (May 2003). "HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins". Trends Biochem. Sci. 28 (5): 224–6. doi:10.1016/S0968-0004(03)00060-4. PMID 12765831.
This article incorporates text from the public domain Pfam and InterPro: IPR007842