HEPACAM2

HEPACAM2
Identifiers
Aliases	HEPACAM2, MIKI, HEPACAM family member 2
External IDs	OMIM: 614133; MGI: 2141520; HomoloGene: 18724; GeneCards: HEPACAM2; OMA:HEPACAM2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	93,226,469 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	3,498,298 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; mucosa of sigmoid colon; ; rectum; ; islet of Langerhans; ; palpebral conjunctiva; ; mucosa of transverse colon; ; jejunal mucosa; ; testicle; ; duodenum; ; human kidney;
	Top expressed in
	islet of Langerhans; ; left colon; ; crypt of lieberkuhn of small intestine; ; ileum; ; jejunum; ; duodenum; ; intestinal villus; ; Paneth cell; ; right kidney; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; microtubule organizing center; integral component of membrane; Golgi membrane; centrosome; cytoskeleton; membrane; Golgi apparatus; spindle; midbody;
Biological process	cell cycle; cell division; centrosome cycle;
	Sources:Amigo / QuickGO
Orthologs
	253012
	101202
	ENSG00000188175
	ENSMUSG00000044156
	A8MVW5
	Q4VAH7
	NM_001039372; NM_001288804; NM_001288810; NM_198151; NM_001346642
	NM_178899
	NP_001034461; NP_001275733; NP_001275739; NP_001333571; NP_937794
	NP_849230
	Wikidata
View/Edit Human	View/Edit Mouse

HEPACAM family member 2 is a protein that in humans is encoded by the HEPACAM2 gene. ^[5]

Function

This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology, and apoptosis.

Poly (ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188175 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044156 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: HEPACAM family member 2". Retrieved 2017-09-13.

Function

References

Further reading