HEBP1

HEBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GOV, 2HVA, 4A1M
Identifiers
Aliases	HEBP1, HBP, HEBP, heme binding protein 1
External IDs	OMIM: 605826; MGI: 1333880; HomoloGene: 8407; GeneCards: HEBP1; OMA:HEBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	13,000,265 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	135,175,020 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; mucosa of ileum; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; trabecular bone; ; parotid gland; ; left adrenal cortex; ; left lobe of thyroid gland;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; left lobe of liver; ; yolk sac; ; tibiofemoral joint; ; spleen; ; white adipose tissue; ; subcutaneous adipose tissue; ; gastrula; ; migratory enteric neural crest cell; ; efferent ductule;
	More reference expression data
	n/a
Gene ontology
Molecular function	heme binding;
Cellular component	cytoplasm; extracellular region; extracellular exosome; cytosol;
Biological process	circadian rhythm; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	50865
	15199
	ENSG00000013583
	ENSMUSG00000042770
	Q9NRV9
	Q9R257
	NM_015987
	NM_013546
	NP_057071
	NP_038574
	Wikidata
View/Edit Human	View/Edit Mouse

Heme binding protein 1 is a protein that in humans is encoded by the HEBP1 gene.^[5]

Function

The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000013583 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042770 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Heme binding protein 1".

Jacob Blackmon B, Dailey TA, Lianchun X, Dailey HA (Nov 2002). "Characterization of a human and mouse tetrapyrrole-binding protein". Archives of Biochemistry and Biophysics. 407 (2): 196–201. doi:10.1016/s0003-9861(02)00471-x. PMID 12413491.
Gao JL, Guillabert A, Hu J, Le Y, Urizar E, Seligman E, Fang KJ, Yuan X, Imbault V, Communi D, Wang JM, Parmentier M, Murphy PM, Migeotte I (Feb 2007). "F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor". Journal of Immunology. 178 (3): 1450–6. doi:10.4049/jimmunol.178.3.1450. PMID 17237393.
Micaelo NM, Macedo AL, Goodfellow BJ, Félix V (Nov 2010). "Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins". Journal of Molecular Graphics & Modelling. 29 (3): 396–405. doi:10.1016/j.jmgm.2010.07.008. PMID 20800521.
Migeotte I, Riboldi E, Franssen JD, Grégoire F, Loison C, Wittamer V, Detheux M, Robberecht P, Costagliola S, Vassart G, Sozzani S, Parmentier M, Communi D (Jan 2005). "Identification and characterization of an endogenous chemotactic ligand specific for FPRL2". The Journal of Experimental Medicine. 201 (1): 83–93. doi:10.1084/jem.20041277. PMC 2212760. PMID 15623572.
Devosse T, Dutoit R, Migeotte I, De Nadai P, Imbault V, Communi D, Salmon I, Parmentier M (Aug 2011). "Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3". Journal of Immunology. 187 (3): 1475–85. doi:10.4049/jimmunol.1003545. PMID 21709160.
Zylka MJ, Reppert SM (Dec 1999). "Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches". Brain Research. Molecular Brain Research. 74 (1–2): 175–81. doi:10.1016/s0169-328x(99)00277-6. PMID 10640688.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000013583 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042770 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Heme binding protein 1".

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Function

References

Further reading