HARS2

HARS2
Identifiers
Aliases	HARS2, HARSL, HARSR, HO3, PRLTS2, histidyl-tRNA synthetase 2, mitochondrial, HisRS
External IDs	OMIM: 600783; MGI: 1918041; HomoloGene: 40819; GeneCards: HARS2; OMA:HARS2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.3 Start 140,691,430 bp End 140,699,305 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 B2 Start 36,916,061 bp End 36,925,615 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum apex of heart granulocyte mucosa of transverse colon right adrenal cortex rectum right uterine tube body of uterus right ovary Top expressed in neural layer of retina ventricular zone spermatocyte superior frontal gyrus right kidney primary visual cortex granulocyte thymus proximal tubule cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aminoacyl-tRNA ligase activity nucleotide binding ligase activity protein binding ATP binding protein homodimerization activity histidine-tRNA ligase activity RNA binding identical protein binding Cellular component cytoplasm mitochondrial matrix mitochondrion cytosol Biological process protein biosynthesis histidyl-tRNA aminoacylation mitochondrial translation tRNA aminoacylation for protein translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23438 70791 Ensembl ENSG00000112855 ENSMUSG00000019143 UniProt P49590 Q99KK9 RefSeq (mRNA) NM_001278731 NM_001278732 NM_012208 NM_001363535 NM_001363536 NM_080636 NM_001305627 NM_001360921 RefSeq (protein) NP_001265660 NP_001265661 NP_036340 NP_001350464 NP_001350465 NP_001292556 NP_542367 NP_001347850 Location (UCSC) Chr 5: 140.69 – 140.7 Mb Chr 18: 36.92 – 36.93 Mb PubMed search
Wikidata
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Probable histidyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the HARS2 gene.

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter.

Further reading

• Freist W, Verhey JF, Rühlmann A, et al. (1999). "Histidyl-tRNA synthetase". Biol. Chem. 380 (6): 623–46. doi:10.1515/BC.1999.079. PMID 10430027.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lama J, Trono D (1998). "Human immunodeficiency virus type 1 matrix protein interacts with cellular protein HO3". J. Virol. 72 (2): 1671–6. doi:10.1128/JVI.72.2.1671-1676.1998. PMC 124654. PMID 9445076.
• Tsui HW, Mok S, de Souza L, et al. (1993). "Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element". Gene. 131 (2): 201–8. doi:10.1016/0378-1119(93)90294-D. PMID 8406012.
• Raben N, Borriello F, Amin J, et al. (1992). "Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases". Nucleic Acids Res. 20 (5): 1075–81. doi:10.1093/nar/20.5.1075. PMC 312093. PMID 1549469.