After graduating from Supinfocom, Cassuto began his career working on commercials, short films, television shows, and music videos. He was a lighting and rendering artist for Picasso Pictures, alighting, rendering, and compositing technical director for Superfad, The Mill, and Passion Pictures, and a VFX and rendering artist for Nexus Studios. From 2011 to 2017, he worked as a background artist, compositing supervisor, and writer for the Cartoon Network series The Amazing World of Gumball. Cassuto then left the show on October 27, 2017, and created the Cartoon Networkanimated seriesElliott from Earth.[1][2][3][4] But as of the end of October 2019, Cassuto, due to a "mutual parting of ways" with Cartoon Network, left production and stepped down as showrunner.[5][6] Cassuto is currently based in London, England. As of 2021, he is currently directing animation projects and music videos.