Gsk3b interacting protein

GSKIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SGO
Identifiers
Aliases	GSKIP, C14orf129, HSPC210, GSK3B interacting protein
External IDs	OMIM: 616605; MGI: 1914037; HomoloGene: 9522; GeneCards: GSKIP; OMA:GSKIP - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.2 Start 96,363,452 bp End 96,387,288 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 E Start 105,651,088 bp End 105,669,282 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte mucosa of ileum jejunal mucosa mucosa of colon palpebral conjunctiva mucosa of sigmoid colon pancreatic epithelial cell oral cavity gingival epithelium endothelial cell Top expressed in otolith organ utricle substantia nigra Paneth cell Region I of hippocampus proper arcuate nucleus sciatic nerve hand Rostral migratory stream ventromedial nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein kinase inhibitor activity beta-catenin binding protein kinase A regulatory subunit binding protein kinase A binding protein kinase binding Cellular component cytoplasm nucleus Biological process negative regulation of protein kinase activity intrinsic apoptotic signaling pathway in response to oxidative stress positive regulation of canonical Wnt signaling pathway regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51527 66787 Ensembl ENSG00000100744 ENSMUSG00000044715 UniProt Q9P0R6 Q8BGR8 RefSeq (mRNA) NM_016472 NM_001271904 NM_001271905 NM_001271906 NM_178613 RefSeq (protein) NP_001258833 NP_001258834 NP_001258835 NP_057556 NP_848728 Location (UCSC) Chr 14: 96.36 – 96.39 Mb Chr 12: 105.65 – 105.67 Mb PubMed search
Wikidata
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GSK3B interacting protein is a protein that in humans is encoded by the GSKIP gene.

Function

This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene.

Further reading

• Chou HY, Howng SL, Cheng TS, Hsiao YL, Lieu AS, Loh JK, Hwang SL, Lin CC, Hsu CM, Wang C, Lee CI, Lu PJ, Chou CK, Huang CY, Hong YR (2006). "GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta". Biochemistry. 45 (38): 11379–89. doi:10.1021/bi061147r. PMID 16981698.
• Tang XN, Lo CW, Chuang YC, Chen CT, Sun YC, Hong YR, Yang CN (2011). "Prediction of the binding mode between GSK3β and a peptide derived from GSKIP using molecular dynamics simulation". Biopolymers. 95 (7): 461–71. doi:10.1002/bip.21603. PMID 21328310.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.