gntR-DTE RNA motif
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| gntR-DTE | |
|---|---|
 Consensus secondary structure and sequence conservation of gntR-DTE RNA | |
| Identifiers | |
| Symbol | gntR-DTE |
| Rfam | RF02989 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | SO:0001263 |
| PDB structures | PDBe |
The gntR-DTE RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] gntR-DTE motifs are found in some, but not all species within the genus Streptomyces.
It is ambiguous whether gntR-DTE RNAs function as cis-regulatory elements or whether they operate in trans as small RNAs. Of the 7 known examples of gntR RNAs, 6 are upstream of protein-coding genes, suggesting a cis-regulatory function. However, having more than 10% of the RNAs no upstream of a protein-coding gene would be unusually high for a cis-regulatory RNA. Additionally, the reverse-complement of the RNA would be consistently upstream of protein-coding genes, of which most encode helix-turn-helix proteins of the XRE-like family. However, there is no other evidence to suggest that the RNA is transcribed from the opposite strand.
References
[edit]- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.