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Glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)

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glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)
Identifiers
EC no.1.2.1.13
CAS no.37250-87-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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In enzymology, a glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) (EC 1.2.1.13) is an enzyme that catalyzes the chemical reaction

D-glyceraldehyde 3-phosphate + phosphate + NADP+ 3-phospho-D-glyceroyl phosphate + NADPH + H+

The 3 substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate, and NADP+, whereas its 3 products are 3-phospho-D-glyceroyl phosphate, NADPH, and H+.

Function

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This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in the Calvin cycle which is an autotrophic carbon fixation pathway.

Nomenclature

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The systematic name of this enzyme class is D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating). Other names in common use include:

  • dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)
  • GAPDH
  • glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)
  • glyceraldehyde-3-phosphate dehydrogenase (NADP) (phosphorylating)
  • NADP-dependent glyceraldehyde phosphate dehydrogenase
  • NADP-glyceraldehyde phosphate dehydrogenase
  • NADP-glyceraldehyde-3-phosphate dehydrogenase
  • NADP-triose phosphate dehydrogenase
  • triosephosphate dehydrogenase (NADP)

References

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Further reading

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  • Brenneman FN, Volk WA (1959). "Glyceraldehyde phosphate dehydrogenase activity with triphosphopyridine nucleotide and with diphosphopyridine nucleotide". J. Biol. Chem. 234 (9): 2443–7. doi:10.1016/S0021-9258(18)69832-1. PMID 13804190.
  • Gibbs M (1955). [62] TPN triosephosphate dehydrogenase from plant tissue. Methods Enzymol. Vol. 1. pp. 411–415. doi:10.1016/0076-6879(55)01067-7. ISBN 978-0-12-181801-2.
  • Rosenberg LL, Arnon DI (1955). "The preparation and properties of a new glyceraldehyde-3-phosphate dehydrogenase from photosynthetic tissues". J. Biol. Chem. 217 (1): 361–71. doi:10.1016/S0021-9258(19)57187-3. PMID 13271400.