Geranylgeranylglycerol-phosphate geranylgeranyltransferase
| geranylgeranylglycerol-phosphate geranylgeranyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.42 | ||||||||
| CAS no. | 124650-68-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a geranylgeranylglycerol-phosphate geranylgeranyltransferase (EC 2.5.1.42) is an enzyme that catalyzes the chemical reaction
- geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate
Thus, the two substrates of this enzyme are geranylgeranyl diphosphate and sn-3-O-(geranylgeranyl)glycerol 1-phosphate, whereas its two products are diphosphate and 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring aryl groups or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase. Other names in common use include geranylgeranyloxyglycerol phosphate geranylgeranyltransferase, and geranylgeranyltransferase II.
Structural studies
[edit]As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2F6U and 2F6X.
References
[edit]- Zhang DL, Daniels L, Poulter CD (1990). "Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction". J. Am. Chem. Soc. 112 (3): 1264–1265. doi:10.1021/ja00159a067.
