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Gary Desir

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Gary Desir
Born
Gary V. Desir
Alma materNew York University
Yale University
Known forDiscovery of Renalase
SpousesDeborah Dyett Desir[1][2]
Scientific career
FieldsNephrology and molecular physiology
InstitutionsYale University
Yale School of Medicine
VA Connecticut Healthcare System
School of Forestry and Environmental Studies
Albert Schweitzer Hospital

Gary V. Desir is a physician, researcher and medical practitioner who was appointed as the vice provost for faculty development and diversity at Yale University in March 2020.[3][4][5] Desir is also the chair of the department of internal medicine at Yale School of Medicine, and was formerly the chair of the Yale Medicine Board. His areas of specialization include nephrology and molecular physiology, the latter specifically about potassium channels.[6] His notable research work includes discovery of the kidney protein renalase.[7][8][9]

Early life and career

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Desir was born in Haiti[10] and has studied rhétorique from St Louis de Gonzague. He moved to the US in 1972 and in 1973 he enrolled in the bachelors program at New York University. In 1976, he graduated as a BS in biology while receiving the membership of Phi Beta Kappa.[11] In 1980, he graduated with honors from Yale University and became part of the Alpha Omega Alpha.[12] From 1980 to 1983 he trained in internal medicine. He took part in the fellowship program in nephrology. He worked for 3 years as the research fellowship at Yale University in nephrology with specialization in potassium channels (molecular physiology).

In 1988, Desir was appointed as an assistant professor at Yale School of Medicine. He became associate professor and professor in 1993 and 2003 respectively. From 1997 to 2004, he served as the section chief of nephrology at the VA Connecticut Healthcare System. He worked as the chair of internal medicine at VACHS from 2004 to 2013.[13] In 2013, he was appointed on interim basis as the chair of the department of internal medicine at Yale School of Medicine.[14] He was appointed to the permanent chair in 2015.[15] In 2016 Desir was designated as the Paul B. Beeson Professor of Internal Medicine at Yale.[16] Desir is also vice provost for faculty development and diversity.[17][18]

Research activities

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Desir's most notable research activity include the discovery of the agent renalase, which is basically a renal protein. It can be classified as an enzyme as well as a hormone - such nature being decided on its site of action with the prospect of being used in dual-purpose.[19] The primary function of renalase is as an intracellular enzyme that controls and manipulates energy production at granular level. It also has the protective characteristics that it exhibits against cell injury and stress, once it secretes in the plasma.[20][21]

Desir is also the founder of biotech firm Personal Therapeutics, that works exploring the prospects of commercializing renalase and its pathway while basing the foundations in two concepts, viz. renalase agonist and renalase antagonist. Renalase agonist primarily deals with the role of renalase in mitigating tissue injury in myocardial infarction whereas renalase antagonist is based on the concept of fighting cancer cells[22] which "highjack the renalase pathway as a survival mechanism".[23][24][25] During covid-19 pandemic, a correlation was claimed in a Yale researchers report between low levels of the renalase and poor outcome of clinical treatment of covid patients.[26][27]

Other activities

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Desir is an active advocate of diversity, equity and inclusion[28] and a founding member of the Minority Organization for Retention & Expansion executive committee of Yale.[29][30] Under dual teaching appointment, Desir conducts the graduate course "Sustainable Development in a Post-Disaster Context" at the School of Forestry and Environmental Studies, in collaboration with the Albert Schweitzer Hospital in Deschapelles, Haiti.[31]

Notable publications

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  • Jianchao Xu, Guoyong Li, Peili Wang, Heino Velazquez, Xiaoqiang Yao, Yanyan Li, Yanling Wu, Aldo Peixoto, Susan Crowley, and Gary V. Desir; Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.[32]
  • International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion Channels: Potassium Channels George A. Gutman, K. George Chandy, John P. Adelman, Jayashree Aiyar, Douglas A. Bayliss, David E. Clapham, Manuel Covarriubias, Gary V. Desir, Kiyoshi Furuichi, Barry Ganetzky, Maria L. Garcia, Stephan Grissmer, Lily Y. Jan, Andreas Karschin, Donghee Kim, Sabina Kuperschmidt, Yoshihisa Kurachi, Michel Lazdunski, Florian Lesage, Henry A. Lester, David McKinnon, Colin G. Nichols, Ita O'Kelly, Jonathan Robbins, Gail A. Robertson, Bernardo Rudy, Michael Sanguinetti, Susumu Seino, Walter Stuehmer, Michael M. Tamkun, Carol A. Vandenberg, Aguan Wei, Heike Wulff and Randy S. Wymore[33]
  • Molecular Diversity and Regulation of Renal Potassium Channels ; Steven C. Hebert, Gary Desir, Gerhard Giebisch, and Wenhui Wang[34]
  • Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase Guoyong Li, Jianchao Xu, Peili Wang, Heino Velazquez, Yanyan Li, Yanling Wu, and Gary V. Desir.[35]
  • The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity Jianchao Xu, Peili Wang, Yanyan Li, Guoyong Li, Leonard K. Kaczmarek, Yanling Wu, Pandelakis A. Koni, Richard A. Flavell, and Gary V. Desir.[36]
  • Jianchao Xu, Pandelakis A. Koni, Peili Wang, Guoyong Li, Leonard Kaczmarek, Yanling Wu, Yanyan Li, Richard A. Flavell, Gary V. Desir, The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight, Human Molecular Genetics, Volume 12, Issue 5, 1 March 2003, Pages 551–559,[37]
  • Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman's syndrome Shanti Kunchaparty, Matthew Palcso, Jennifer Berkman, Heino Velázquez, Gary V. Desir, Paul Bernstein, Robert F. Reilly, and David H. Ellison[38]
  • Regulation of blood pressure and cardiovascular function by renalase Author links open overlay panel; Gary V.Desir [39]
  • Renalase Lowers Ambulatory Blood Pressure by Metabolizing Circulating Adrenaline Gary V. Desir, LieQi Tang, Peili Wang, Guoyong Li, Benedita Sampaio‐Maia, Janete Quelhas‐Santos, Manuel Pestana, and Heino Velazquez[40]
  • A Functional Polymorphism in Renalase (Glu37Asp) Is Associated with Cardiac Hypertrophy, Dysfunction, and Ischemia: Data from the Heart and Soul Study Ramin Farzaneh-Far, Gary V. Desir,Beeya Na,Nelson B. Schiller,Mary A. Whooley [41]
  • Renalase in hypertension and kidney disease, Nephrology Dialysis Transplantation, Gary V. Desir, Aldo J. Peixoto, Volume 29, Issue 1, January 2014, Pages 22–28,[42]

References

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  1. ^ "Deborah E. Dyett And Gary DeSir Set Bridal for Aug. 26". The New York Times. 1979-04-08. ISSN 0362-4331. Retrieved 2021-09-29.
  2. ^ "Theta Epsilon Omega Chapter - Deborah Dyett Desir, MD, Joins ACR Executive Committee as Secretary". www.akanewhaven.org. Retrieved 2021-09-29.
  3. ^ Parry, Julie. "Desir Named Vice Provost for Faculty Development and Diversity". medicine.yale.edu. Retrieved 2021-09-17.
  4. ^ "Founders Day: Building a Stronger and More Inclusive Yale". Office of the President. 2020-10-14. Retrieved 2021-09-17.
  5. ^ Stevens, Chester (2020-10-14). "Salovey unveils new plans for equity, belonging at Yale". University News HQ. Retrieved 2021-09-17.
  6. ^ "amhe.org". Retrieved 2021-09-17.
  7. ^ "Kidney enzyme renalase a potential therapy for severe COVID-19". News-Medical.net. 2020-06-07. Retrieved 2021-09-17.
  8. ^ "What is Renalase?". News-Medical.net. 2020-07-01. Retrieved 2021-09-17.
  9. ^ Guo, Xiaojia; Hollander, Lindsay; MacPherson, Douglas; Wang, Ling; Velazquez, Heino; Chang, John; Safirstein, Robert; Cha, Charles; Gorelick, Fred; Desir, Gary V. (2016-03-14). "Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer". Scientific Reports. 6 (1): 22996. Bibcode:2016NatSR...622996G. doi:10.1038/srep22996. ISSN 2045-2322. PMC 4789641. PMID 26972355.
  10. ^ Parry, Julie. "Desir Shares Life Story, Advice in "The Importance of Being Present"". medicine.yale.edu. Retrieved 2021-09-17.
  11. ^ "Gary V. Desir, M.D., appointed Chair and Chief of Internal Medicine". medicine.yale.edu. Retrieved 2021-09-17.
  12. ^ "Gary Desir, MD". medicine.yale.edu. Retrieved 2021-09-17.
  13. ^ "Gary V. Desir, M.D., appointed Chair and Chief of Internal Medicine". medicine.yale.edu. Retrieved 2021-09-17.
  14. ^ "Gary V. Desir, M.D., HS '83, FW '87, named interim chair of internal medicine". medicine.yale.edu. Retrieved 2021-09-17.
  15. ^ "More news about Yale people". yalealumnimagazine.com. Retrieved 2021-09-17.
  16. ^ "Dr. Gary Desir designated the Beeson Professor of Internal Medicine". YaleNews. 2016-09-06. Retrieved 2021-09-17.
  17. ^ "DIM Comp R2". Issuu. Retrieved 2021-09-29.
  18. ^ Sanger, Catherine Shea; Gleason, Nancy W., eds. (2020). Diversity and Inclusion in Global Higher Education. doi:10.1007/978-981-15-1628-3. ISBN 978-981-15-1627-6. S2CID 237868497.
  19. ^ "Gary Desir". Yale Medicine. Retrieved 2021-09-17.
  20. ^ Desir, Gary (2012). "Novel insights into the physiology of renalase and its role in hypertension and heart disease". Pediatric Nephrology (Berlin, Germany). 27 (5): 719–725. doi:10.1007/s00467-011-1828-7. ISSN 1432-198X. PMID 21424526. S2CID 8473507.
  21. ^ Desir, Gary. "Renalase Deficiency and Cardiovascular Complications of Chronic Kidney Disease".
  22. ^ Castillo, Grace (2016-03-29). "Potential treatment for pancreatic cancer on horizon". Yale Daily News. Retrieved 2021-09-17.
  23. ^ "AMHE Newsletter. In this number. Winter Haitian Medical Association Abroad Association Medicale Haïtienne à l'étranger. - PDF Free Download". docplayer.fr. Retrieved 2021-09-17.
  24. ^ Guo, Xiaojia; Hollander, Lindsay; MacPherson, Douglas; Wang, Ling; Velazquez, Heino; Chang, John; Safirstein, Robert; Cha, Charles; Gorelick, Fred; Desir, Gary V. (2016-03-14). "Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer". Scientific Reports. 6 (1): 22996. Bibcode:2016NatSR...622996G. doi:10.1038/srep22996. ISSN 2045-2322. PMC 4789641. PMID 26972355.
  25. ^ Wang, Yang; Safirstein, Robert; Velazquez, Heino; Guo, Xiao-Jia; Hollander, Lindsay; Chang, John; Chen, Tian-Min; Mu, Jian-Jun; Desir, Gary V. (2017). "Extracellular renalase protects cells and organs by outside-in signalling". Journal of Cellular and Molecular Medicine. 21 (7): 1260–1265. doi:10.1111/jcmm.13062. ISSN 1582-1838. PMC 5487909. PMID 28238213.
  26. ^ "Blood protein predicts poor COVID-19 outcomes". medicalxpress.com. Retrieved 2021-09-17.
  27. ^ "Kidney enzyme renalase a potential therapy for severe COVID-19". News-Medical.net. 2020-06-07. Retrieved 2021-09-17.
  28. ^ Parry, Julie. "Diversity, Equity, Inclusion Focus Of Department of Internal Medicine". medicine.yale.edu. Retrieved 2021-09-17.
  29. ^ "Who We Are". medicine.yale.edu. Retrieved 2021-09-17.
  30. ^ ""Black Women in Medicine" Documentary to Screen at Yale on Tuesday 4/26". Good Black News. 2016-04-24. Retrieved 2021-09-17.
  31. ^ Xiong, Amy (2018-03-30). "Global Health Day addresses climate change". Yale Daily News. Retrieved 2021-09-17.
  32. ^ Xu, Jianchao; Li, Guoyong; Wang, Peili; Velazquez, Heino; Yao, Xiaoqiang; Li, Yanyan; Wu, Yanling; Peixoto, Aldo; Crowley, Susan; Desir, Gary V. (2005-05-02). "Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure". Journal of Clinical Investigation. 115 (5): 1275–1280. doi:10.1172/JCI24066. ISSN 0021-9738. PMC 1074681. PMID 15841207.
  33. ^ Gutman, George A.; Chandy, K. George; Adelman, John P.; Aiyar, Jayashree; Bayliss, Douglas A.; Clapham, David E.; Covarriubias, Manuel; Desir, Gary V.; Furuichi, Kiyoshi; Ganetzky, Barry; Garcia, Maria L. (2003-12-01). "International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion Channels: Potassium Channels". Pharmacological Reviews. 55 (4): 583–586. doi:10.1124/pr.55.4.9. PMID 14657415. S2CID 34963430.
  34. ^ Hebert, Steven C.; Desir, Gary; Giebisch, Gerhard; Wang, Wenhui (2005-01-01). "Molecular Diversity and Regulation of Renal Potassium Channels". Physiological Reviews. 85 (1): 319–371. doi:10.1152/physrev.00051.2003. ISSN 0031-9333. PMC 2838721. PMID 15618483.
  35. ^ Li, Guoyong; Xu, Jianchao; Wang, Peili; Velazquez, Heino; Li, Yanyan; Wu, Yanling; Desir, Gary V. (2008-03-11). "Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase". Circulation. 117 (10): 1277–1282. doi:10.1161/CIRCULATIONAHA.107.732032. PMID 18299506. S2CID 6658935.
  36. ^ Xu, Jianchao; Wang, Peili; Li, Yanyan; Li, Guoyong; Kaczmarek, Leonard K.; Wu, Yanling; Koni, Pandelakis A.; Flavell, Richard A.; Desir, Gary V. (2004-03-02). "The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity". Proceedings of the National Academy of Sciences. 101 (9): 3112–3117. Bibcode:2004PNAS..101.3112X. doi:10.1073/pnas.0308450100. PMC 365752. PMID 14981264.
  37. ^ Xu, J. (2003-03-01). "The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight". Human Molecular Genetics. 12 (5): 551–559. doi:10.1093/hmg/ddg049. ISSN 1460-2083. PMID 12588802.
  38. ^ Kunchaparty, Shanti; Palcso, Matthew; Berkman, Jennifer; Velázquez, Heino; Desir, Gary V.; Bernstein, Paul; Reilly, Robert F.; Ellison, David H. (1999-10-01). "Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman's syndrome". American Journal of Physiology. Renal Physiology. 277 (4): F643–F649. doi:10.1152/ajprenal.1999.277.4.F643. ISSN 1931-857X. PMID 10516289.
  39. ^ Desir, Gary V. (2009). "Regulation of blood pressure and cardiovascular function by renalase". Kidney International. 76 (4): 366–370. doi:10.1038/ki.2009.169. ISSN 0085-2538. PMID 19471322.
  40. ^ Desir, Gary V.; Tang, LieQi; Wang, Peili; Li, Guoyong; Sampaio-Maia, Benedita; Quelhas-Santos, Janete; Pestana, Manuel; Velazquez, Heino (2012). "Renalase Lowers Ambulatory Blood Pressure by Metabolizing Circulating Adrenaline". Journal of the American Heart Association. 1 (4): e002634. doi:10.1161/JAHA.112.002634. PMC 3487338. PMID 23130169.
  41. ^ Farzaneh-Far, Ramin; Desir, Gary V.; Na, Beeya; Schiller, Nelson B.; Whooley, Mary A. (2010-10-20). "A Functional Polymorphism in Renalase (Glu37Asp) Is Associated with Cardiac Hypertrophy, Dysfunction, and Ischemia: Data from the Heart and Soul Study". PLOS ONE. 5 (10): e13496. Bibcode:2010PLoSO...513496F. doi:10.1371/journal.pone.0013496. ISSN 1932-6203. PMC 2958117. PMID 20975995.
  42. ^ Desir, Gary V.; Peixoto, Aldo J. (2013-10-17). "Renalase in hypertension and kidney disease". Nephrology Dialysis Transplantation. 29 (1): 22–28. doi:10.1093/ndt/gft083. ISSN 1460-2385. PMID 24137013.
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